Nanostructured Ceria: Biomolecular Templates and (Bio)applications

Rozhin, Petr; Melchionna, Michele; Fornasiero, Paolo; Marchesan, Silvia

doi:10.3390/nano11092259

Cited by 33 publications

(25 citation statements)

References 264 publications

(311 reference statements)

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“…28,[34][35][36] On the other hand, ceria has a very high chemical affinity to phosphate species. [37][38][39] Upon interaction with phosphates, the redox cycling between Ce +3 /Ce +4 in nanoceria can be blocked, 40 preventing any potential positive cytoprotective effects of this material in cosmetic applications. Bearing in mind that organophosphates (e.g.…”

Section: Introductionmentioning

confidence: 99%

Amorphous and crystalline cerium(iv) phosphates: biocompatible ROS-scavenging sunscreens

et al. 2022

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Section: Introductionmentioning

confidence: 99%

Amorphous and crystalline cerium(iv) phosphates: biocompatible ROS-scavenging sunscreens

et al. 2022

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“…[ 74 ] CeNPs are suitable for various biomedical applications, including as free‐radical scavengers, for radiation protection, cancer biomarkers, and therapy for cardiovascular complications or neurological sequelae. [ 71,75 ] One research report developing multi‐stimuli responsive CeNPs‐based MSNs systems for intracellular drug delivery. [ 76 ] The smart drug delivery therapeutic nanoplatforms consisted of MSNs containing drugs inside the pores and CeNPs as lids (gatekeepers, capping agents) covering the pores.…”

Section: Discussionmentioning

confidence: 99%

Free‐Blockage Mesoporous Silica Nanoparticles Loaded with Cerium Oxide as ROS‐Responsive and ROS‐Scavenging Nanomedicine

Purikova

Ткаченко

Veltruská

et al. 2022

Adv Funct Materials

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Mesoporous silica nanoparticles (MSNs) with reactive oxygen species (ROS)-responsive "nanogate" as drug delivery platforms are extensively investigated for biomedical applications. However, the physical blockages used to control the cargo release are often limited by their poor sealing ability and low biocompatibility. Herein, a design of free-blockage MSNs with methylthiopropyl units is proposed as the ROS-responsive switch. Four synthetic routes are compared with different precursors through either co-condensation or grafting methods to achieve the methylthio-functionalized MSNs. The quantity, localization, and chemical structure of the functional units, as well as the mesoporous structure of the silica can be tuned by optimizing the synthetic pathways to obtain desired final products. The ROS-responsive methylthiopropyl groups can be oxidized to sulfoxides in response to the presence of H 2 O 2 , leading to the hydrophobic/hydrophilic conversion of the MSNs. As a proof-of-concept design, ultrasmall cerium oxide nanoparticles are encapsulated into the functionalized MSNs and released out within 10 min scavenging more than 80% of the H 2 O 2 in an ROS-rich environment. This study provides a novel design of a free-blockage ROS-controlled release system loaded with ROS-scavenging nanoparticles for the future application of targeted drug delivery systems combined with antioxidant therapy.

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“…Like most trace elements, Ce depending on the concentration can have both positive and negative effects on the growth and development of algae. It is known that in the aqueous medium NP CeO2 undergo redox modifications, form polydisperse aggregates, which lead to a change in their catalytic activity (Santschi et al 2017;Gagnon et al 2018;Rozhin et al 2021).…”

Section: Discussionmentioning

confidence: 99%

The specificity of changes in key performance indicators of green algae of the family Scenedesmaceae under the influence of cerium

Cheban

Shcherbakov²,

Nm³

et al. 2022

Nova Biotechnol. Chim.

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The effect of various concentrations (1 μM – 100 mM) of citrate-stabilized cerium dioxide nanoparticles or cerium ions (3+) on the biomass production of two species of unicellular green algae Desmodesmus armatus (Chod.) Hegew and Acutodesmus dimorphus (Turpin) Tsarenko was studied, the amount of chlorophyll, proteins and lipids in the algae biomass was determined. It was shown that at the concentrations of 0.01 M to 0.1 M nanoparticles and cerium salt have pronounced toxic effects on the algal cultures, manifested by a sharp increase in the level of lipids in the biomass combined with the decrease in chlorophyll and protein. At lower concentrations, cerium dioxide nanoparticles stimulate algae biomass accumulation, probably due to a change in key metabolic pathways, accompanied by an increase in the accumulation of carbohydrates in the biomass. For cerium salt, these effects are less pronounced. Thus, depending on the concentration of the objects used, it is possible to obtain an increase in the food biomass production enriched with lipids or carbohydrates as appropriate to the biotechnological objectives.

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Nanostructured Ceria: Biomolecular Templates and (Bio)applications

Cited by 33 publications

References 264 publications

Amorphous and crystalline cerium(iv) phosphates: biocompatible ROS-scavenging sunscreens

Amorphous and crystalline cerium(iv) phosphates: biocompatible ROS-scavenging sunscreens

Free‐Blockage Mesoporous Silica Nanoparticles Loaded with Cerium Oxide as ROS‐Responsive and ROS‐Scavenging Nanomedicine

The specificity of changes in key performance indicators of green algae of the family Scenedesmaceae under the influence of cerium

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