Nanostructured lipid carrier (NLC)-based novel hydrogels as potential carriers for nepafenac applied after cataract surgery for the treatment of inflammation: design, characterization and in vitro cellular inhibition and uptake studies

Abstract

Schematic illustration of the novel formulation (nanostructured lipid carriers-based novel hydrogels) instills into the surface of eyes and the results of cytotoxicity and cell uptake for optimal formulation.

Systemic Design and Evaluation of Ticagrelor-Loaded Nanostructured Lipid Carriers for Enhancing Bioavailability and Antiplatelet Activity

“…The encapsulation efficiency of TGL-NLC was evaluated by the ultrafiltration method [16]. Briefly, the cooled TGL-NLC dispersion before lyophilization was ultra-centrifugated with a centrifuge tube (MWCO 10 kDa, Amicon Ultra; Millipore, Billerica, MA, USA) for 20 min at 15,000g at 4 °C.…”

Enhanced delivery of melatonin loaded nanostructured lipid carriers duringin vitrofertilization: NLC formulation, optimization and IVF efficacy

“…In this study, response surface method (RSM) based on central composite design was employed to determine the appropriate range of parameters inuencing the formulation of nanoparticles and optimization of this formulation. 29,30 It allows evaluating the effect of several independent parameters on responses using a limited number of experiments. 31 Here, independent variables were drug to lipid ratio (% w/w) (A), liquid lipid to total lipid ratio (% w/w) (B), and surfactant to lipid ratio (% w/w) (C).…”

Luliconazole‐loaded nanostructured lipid carriers for topical treatment of superficial Tinea infections

“…Appropriate amount of pure luliconazole, palmitic acid, and lyophilized NLC sample was placed in hermatically sealed aluminium pans and empty sealed pan was used as the reference sample. The thermogram was recorded at a heating rate of 5 C/min with nitrogen as a purging gas over a temperature range of 20 to 300 C 22. 3.12 | Evaluation of NLC loaded gel3.12.1 | Physical appearance and pH determinationPrepared gel was evaluated for texture, uniformity and clarity.…”