Nanostructured Lipid Carriers

Wen, Jingyuan; Chen, Guan-Yu; Chen, Shuo

doi:10.1002/9781119247159.ch6

Cited by 2 publications

(1 citation statement)

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“…All these results show that the location of oxidizable fat in O/W emulsions influences their chemical stability. In some cases this is a positive effect as found for SLNs or nanostructured lipid carriers that have been reported to provide protection to encapsulated materials (Mehrad, Ravanfar, Licker, Regenstein, & Abbaspourrad, 2018;Wen, J. , Chen, G. and Chen, 2018), but it is clear that this is not necessarily the case. Especially for triglycerides with a narrow melting range, expulsion of oxidizable compounds is likely to occur, therewith promoting oxidation ).…”

Section: Oxidative Stability Of O/w Emulsions: Formation Of Primary Amentioning

confidence: 96%

Combined physical and oxidative stability of food Pickering emulsions

Schröder¹

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Contents Chapter 1 General introduction Chapter 2 Pickering emulsions Chapter 3 Tailored microstructure of colloidal lipid particles for Pickering emulsions with tunable properties Chapter 4 Coalescence stability of Pickering emulsions produced with lipid particles: A microfluidic study Chapter 5 Can we prevent lipid oxidation in emulsions by using fat-based Pickering particles? Chapter 6 Chemical stability of α-tocopherol in colloidal lipid particles with various morphologies Chapter 7 Pickering particles as interfacial reservoirs of antioxidants Chapter 8 Emulsions naturally armored against oxidation and coalescence using biobased particles Chapter 9 General discussion

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Section: Oxidative Stability Of O/w Emulsions: Formation Of Primary Amentioning

confidence: 96%

Combined physical and oxidative stability of food Pickering emulsions

Schröder¹

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Nanostructured lipid carriers: a promising drug carrier for targeting brain tumours

et al. 2022

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Background In recent years, the field of nanotechnology and nanomedicine has transformed the pharmaceutical industry with the development of novel drug delivery systems that overcome the shortcomings of traditional drug delivery systems. Nanostructured lipid carriers (NLCs), also known as the second-generation lipid nanocarriers, are one such efficient and targeted drug delivery system that has gained immense attention all across due to their myriad advantages and applications. Scientific advancements have revolutionized our health system, but still, brain diseases like brain tumour have remained formidable owing to poor prognosis and the challenging drug delivery to the brain tissue. In this review, we highlighted the application and potential of NLCs in brain-specific delivery of chemotherapeutic agents. Main body NLCs are lipid-based formulations with a solid matrix at room temperature and offer advantages like enhanced stability, low toxicity, increased shelf life, improved drug loading capacity, and biocompatibility over other conventional lipid-based nanocarriers such as nanoemulsions and solid lipid nanoparticles. This review meticulously articulates the structure, classification, components, and various methods of preparation exemplified with various research studies along with their advantages and disadvantages. The concept of drug loading and release has been discussed followed by a brief about stability and strategies to improve stability of NLCs. The review also summarizes various in vitro and in vivo research studies on NLCs encapsulated with cytotoxic drugs and their potential application in brain-specific drug delivery. Conclusion NLCs are employed as an important carrier for the delivery of food, cosmetics, and medicines and recently have been used in brain targeting, cancer, and gene therapy. However, in this review, the applications and importance of NLCs in targeting brain tumour have been discussed in detail stating examples of various research studies conducted in recent years. In addition, to shed light on the promising role of NLCs, the current clinical status of NLCs has also been summarized. Graphical Abstract

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Nanostructured Lipid Carriers

Cited by 2 publications

References 96 publications

Combined physical and oxidative stability of food Pickering emulsions

Combined physical and oxidative stability of food Pickering emulsions

Nanostructured lipid carriers: a promising drug carrier for targeting brain tumours

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