Nanostructured lipid carriers as robust systems for topical lidocaine-prilocaine release in dentistry

Ribeiro, Lígia Nunes de Morais; Franz-Montan, Michelle; Breitkreitz, Márcia Cristina; Alcántara, Ana C. S.; Castro, Simone R.; Guilherme, Viviane A.; Barbosa, Raquel de Melo; Paula, Eneida de

doi:10.1016/j.ejps.2016.08.030

Cited by 87 publications

(100 citation statements)

References 66 publications

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“…Solid lipid nanoparticles (SLN), the first generation of these systems, are composed of solid lipids (core) at room temperature, surfactant, and water. Nanostructured lipid carriers (NLC) are the second generation, having as the lipid phase a blend of one or more solid and liquid lipids at room temperature [81]. Both systems still present some disadvantages, such as a possible expulsion of the drug over time (SLN) and low capacity to encapsulate hydrophilic molecules [82] due to limited thermodynamic interactions between the hydrophilic and hydrophobic interfaces of the drug and the lipid nanoparticle, respectively [83].…”

Section: Innovative Hybrid Lipid Nanoparticles: Solid Lipid Nanopartimentioning

confidence: 99%

Advances in Hybrid Polymer-Based Materials for Sustained Drug Release

Ribeiro

Alcántara

Silva

et al. 2017

International Journal of Polymer Science

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The use of biomaterials composed of organic pristine components has been successfully described in several purposes, such as tissue engineering and drug delivery. Drug delivery systems (DDS) have shown several advantages over traditional drug therapy, such as greater therapeutic efficacy, prolonged delivery profile, and reduced drug toxicity, as evidenced by in vitro and in vivo studies as well as clinical trials. Despite that, there is no perfect delivery carrier, and issues such as undesirable viscosity and physicochemical stability or inability to efficiently encapsulate hydrophilic/hydrophobic molecules still persist, limiting DDS applications. To overcome that, biohybrid systems, originating from the synergistic assembly of polymers and other organic materials such as proteins and lipids, have recently been described, yielding molecularly planned biohybrid systems that are able to optimize structures to easily interact with the targets. This work revised the biohybrid DDS clarifying their advantages, limitations, and future perspectives in an attempt to contribute to further research of innovative and safe biohybrid polymer-based system as biomaterials for the sustained release of active molecules.

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Section: Innovative Hybrid Lipid Nanoparticles: Solid Lipid Nanopartimentioning

confidence: 99%

Advances in Hybrid Polymer-Based Materials for Sustained Drug Release

Ribeiro

Alcántara

Silva

et al. 2017

International Journal of Polymer Science

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“…6 In an attempt to develop an efficient pre-anesthetic for transbuccal application, we have previously described an optimized NLC/LDC-PLC (5%) formulation, selected from factorial design, with excellent structural properties, stability, and in vitro sustained release profile for both LAs. 7 Despite the excellent properties of that DDS, the fluidness and low adhesion 8 inherent to most of the colloidal formulations prevented its application as a pre-anesthetic in dentistry.…”

Section: Introductionmentioning

confidence: 99%

“…In this sense, the development of lipid-biopolymer hydrogels based on NLC/LDC-PLC (5%) formulation was described, 7 incorporated in XAN, alginate (ALG), or chitosan (CHT) matrices. The resultant hybrid hydrogels combined the sustained release of the LA provided by the NLC, with the desirable consistency, viscosity, and adhesion afforded by the biopolymer matrix.…”

Section: Introductionmentioning

confidence: 99%

Nanohybrid hydrogels designed for transbuccal anesthesia

Ribeiro

Franz-Montan

Breitkreitz

et al. 2018

IJN

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BackgroundLocal anesthesia in dentistry is by far the most terrifying procedure for patients, causing treatment interruption. None of the commercially available topical formulations is effective in eliminating the pain and phobia associated to the needle insertion and injection.Materials and methodsIn this work we prepared a nanostructured lipid-biopolymer hydrogel for the sustained delivery of lidocaine–prilocaine (LDC-PLC) for transbuccal pre-anesthesia. The lipid was composed of optimized nanostructured lipid carriers (NLC) loaded with 5% LDC-PLC (NLC/LDC-PLC). The biopolymer counterpart was selected among alginate, xanthan (XAN), and chitosan matrices. The XAN-NLC hydrogel presented the most uniform aspect and pseudoplastic rheological profile, as required for topical use; therefore, it was selected for subsequent analyses. Accelerated stability tests under critical conditions (40°C; 75% relative humidity) were conducted for 6 months, in terms of drug content (mg/g), weight loss (%), and pH.ResultsIn vitro LDC-PLC release profile through Franz diffusion cells revealed a bimodal kinetics with a burst effect followed by the sustained release of both anesthetics, for 24 hours. Structural analyses (fourier transform infrared spectroscopy, differential scanning calorimetry and scanning electron microscopy) gave details on the molecular organization of the hybrid hydrogel, confirming the synergic interaction between the components. Safety and efficacy were evaluated through in vitro cell viability (3T3, HaCat, and VERO cells) and in vivo antinociceptive (tail-flick, in mice) tests, respectively. In comparison to a control hydrogel and the eutectic mixture of 5% LDC-PLC cream (EMLA®), the XAN-NLC/LDC-PLC hybrid hydrogel doubled and quadrupled the anesthetic effect (8 hours), respectively.ConclusionConsidering such exciting results, this multifaceted nanohybrid system is now ready to be further tested in clinical trials.

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“…FranzMontan et al 57 showed that topical administration of 10% benzocaine encapsulated in liposomes increases soft tissue anaesthesia but does not induce pulpar anaesthesia. Ribeiro et al 58 prepared nanostructured lipid carriers using cetyl palmitate and capric/caprylic triglycerides as structural lipids and Pluronic 68 as the colloidal stabiliser for the delivery of local anaesthetics (lidocaine and prilocaine) used in dental practice.…”

Section: Nanotechnology and Dental Applicationsmentioning

confidence: 99%

Nanotechnology in Dentistry

Arruda¹,

Oliveira²,

Paula³

et al. 2017

Arch Health Invest

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Introduction: Nanotechnology is a rapidly expanding field that encompasses the development, manipulation, and application of structures on the nanometer scale. Applications of nanotechnology to dentistry are particularly promising and comprise materials and devices designed to achieve maximal therapeutic efficacy with minimal side effects. Objective: This review discusses the advantages of nanotechnology and the different types of nanostructures used in dentistry. Material and Method: In this study, online databases: pubmed, medline and scielo were searched to analyse the current understanding of the potential of nanotechnology in dentistry, including the restoration of tooth structure with nanocomposites and the development of nanoparticles for dentin remineralisation, drug delivery, disease diagnostics, oral analgesia, oral hygiene maintenance, local anaesthesia, tooth desensitisation, and bone tissue repair. Results: The study demonstrated a wide range of nanotechnological strategies in different dentistry areas and suggests that nanotechnology-based delivery systems may be very useful to improve treatment, prevention and repair in dentistry in the future. Conclusion: There is little or no clinical experience for the nanotechnology-based drug delivery systems cited herein. Safety assessments and clinical trials are the next step in their development.

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Nanostructured lipid carriers as robust systems for topical lidocaine-prilocaine release in dentistry

Cited by 87 publications

References 66 publications

Advances in Hybrid Polymer-Based Materials for Sustained Drug Release

Advances in Hybrid Polymer-Based Materials for Sustained Drug Release

Nanohybrid hydrogels designed for transbuccal anesthesia

Nanotechnology in Dentistry

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