Nanostructured lipid carriers for hair follicle-targeted delivery of clindamycin and rifampicin to hidradenitis suppurativa treatment

Skin Regenerative Potential of Cupuaçu Seed Extract (Theobroma grandiflorum), a Native Fruit from the Amazon: Development of a Topical Formulation Based on Chitosan-Coated Nanocapsules

“…Cell viability was measured by MTT (1 mg/mL) reduction in a microplate spectrophotometer at 570 nm (Bio-Tek Pow-erWave model HT, Winooski, VT, USA). For this protocol, a substance was determined as irritating when the percentage tissue viability-assessed by MTT assay-was less than or equal to 50% and as non-irritating when this percentage was above 50% [26].…”

New perspectives on the treatment of hidradenitis suppurativa

“…They observed that this formulation leads to the accumulation of both antibiotics into the follicle, suggesting that it could be a promising formulation for topical treatment. 59 There are increasing reports of resistant bacterial stains. Knowledge of bacterial resistance profile before initiating therapy, choice of combined therapy over monotherapy, and avoidance of empiric treatments are recommended.…”

Comparing the delivery to the hair bulb of two fluorescent molecules of distinct hydrophilicities by different nanoparticles and a serum formulation

“…In agreement with the particular aim of selectively target the hair bulb, as more independently of cargo hydrophilicity as possible, our choice lays on the formulation. However, a more complete picture must be obtained in future research by performing a quantitative approach to the amount of cargo that was indeed penetrating into the stratum corneum, hair follicles and viable skin, for each vehicle (Oliveira et al, 2020;Pereira et al, 2021;Tolentino et al, 2021).…”

“…There are several reported studies that analyze the skin and follicular permeation of drug delivery systems (Abd et al, 2018;Blume-Peytavi et al, 2010;Lauterbach and Müller-Goymann, 2015;Ossadnik et al, 2006;Patzelt et al, 2011;Teichmann et al, 2007). Recently, some nanocarriers were developed to deliver topically drugs with interesting potential to treat acne vulgaris, hidradenitis suppurativa, androgenic alopecia and inflammation-based skin and hair disorders (Angelo et al, 2020;Pereira et al, 2021;Tolentino et al, 2021;Ushirobira et al, 2020). The authors have compared the developed vehicles with commercial ones or with the drug in solution and they have elegantly quantified which percentage of the drug penetrated into the skin specifically through the follicular pathway (Angelo et al, 2020;Pereira et al, 2021;Tolentino et al, 2021;Ushirobira et al, 2020).…”

“…Recently, some nanocarriers were developed to deliver topically drugs with interesting potential to treat acne vulgaris, hidradenitis suppurativa, androgenic alopecia and inflammation-based skin and hair disorders (Angelo et al, 2020;Pereira et al, 2021;Tolentino et al, 2021;Ushirobira et al, 2020). The authors have compared the developed vehicles with commercial ones or with the drug in solution and they have elegantly quantified which percentage of the drug penetrated into the skin specifically through the follicular pathway (Angelo et al, 2020;Pereira et al, 2021;Tolentino et al, 2021;Ushirobira et al, 2020). The different nanoparticles and nanocapsules all promoted the targeting of the HFs regarding the other non-structured vehicles.…”