Nanostructured Lipid Carriers Improve Skin Permeation and Chemical Stability of Idebenone

Abstract

Abstract. Idebenone (IDB) is a synthetic antioxidant and analog of coenzyme Q10. The percutaneous permeation of IDB was investigated in guinea pig skin after application of different formulations. The enhancing effects of various formulations [nanostructured lipid carriers (NLCs), nanoemulsion (NE), or oil solution] on the permeation of IDB were evaluated using ex vivo guinea pig skins. Furthermore, stability of different formulations and in which chemical stability of IDB was determined during storage. Permeation experiments revealed that formulations varied in their ability to enhance the skin permeation of IDB. For NLC formulation, the cumulative amount of IDB in the epidermis, dermis, and acceptor medium of diffusion cells was approximately threefold more than NE or oil solution at the end of 24-h experiment. No significant difference between NE and oil solution was observed in the enhancement of penetration efficacy of IDB. Different formulations resulted in stability with different properties. NLC formulation revealed preferentially more stable than NE. The residual percentage of IDB loaded in NLCs, NE, and oil solution was 90.1%, 65.4%, and 51.3%, respectively, when stored at 40°C under 75% RH and 3,000 lx light conditions for 180 days. The results obtained here demonstrated that the abilities of NLCs to improve the chemical stability of IDB and enhance the skin permeation are much better than NE and oil solution. These suggest that NLCs containing IDB have significant potential use for skin care as an alternative topical formulation.

Solid Lipid Nanoparticles and Nanostructured Lipid Carriers of Loratadine for Topical Application: Physicochemical Stability and Drug Penetration through Rat Skin

“…In a recent study, SLN and NLC were reported to exhibit a high adhesion to the stratum corneum enhancing the amount of drug which penetrated into the viable skin [19]. Lipid nanoparticles formulated in this study are expected to display an occlusive effect and reduce the transepidermal water loss.…”

“…Nanometer size range of SLN and NLC can provide occlusive effect leading to an increase in skin hydration by their close contact with the stratum corneum [5,19]. Skin hydration can cause subsequent increase in skin penetration of a drug or transfer of it into deeper layers of skin.…”

Nanostructured Lipid Carriers: A Groundbreaking Approach for Transdermal Drug Delivery

“…Data obtained is interpreted by calculating the volume distribution denoted by Dv (10), Dv(50), Dv (90).The parameter Dv(90) indicates the size point upto which 90% of cumulative volume of material in a given sample is contained. Similarly, Dv(50) value gives size point below which 50 % of the sample has the given size.…”

The Properties and Application of Argan Oil in Cosmetology

“…[106,109,110,111] Nanostructured Lipid Carriers are nanostructured coloidal carriers consisting of oil, water, and surfractants (blends of solid and liquid lipids (oils)) without the majority of the disadvantages of their predecessors. [100,108,114,115] The use of nanoparticles improves the stability of chemically unstable active ingredients and their controlled release. [100,108,114,115] The use of nanoparticles improves the stability of chemically unstable active ingredients and their controlled release.…”