Nanostructured Lipid Carriers System Solid Lipid Poloxamer and Stearic Acid with Liquid Lipid Soybean Oil

Abstract

Nanostructured Lipid Carriers (NLC) are lipid-based carrier system that use a matrix combination in the form of solid and liquid which are stabilized with the addition of surfactant. This NLC was developed to facilitate the dispersion of hydrophobic bioactive compound in a hydrophilic system. This research aims to get the right formulation and can develop stable characterization, using solid lipids Poloxamer and Stearic Acid with liquid lipids Soybeans Oil using surfactant Tween 80 and co-surfactant Propyleneglycol.. The to make the formulation of NLC with a ratio of poloxamer and stearic acid as solid lipid: soybeans oil asliquid lipid is 3:3, 4:2, 5:1 ,surfactant tween 80 and co surfactant propyleneglycol. Test the NLC characterization including PH value, viscosity, particle size, and polydispersity index. Data analysis used to evaluate the characteristics of the obtained NLC using descriptive. The result of the research showed that NLC had good characteistics at a solid lipid poloxamer and stearic acid with Soybean oil liquid lipid ,pH in the range 4-6; good viscosity; good particles have a range of 1000nm; and polydispersity index which shows the results of monodispersion. Nanostructured Llipid Carriers with solid lipid poloxamer and stearic acid and liquid lipid soybean oil obtained good characteristics.

Review: Review Article Lipid-Based Nanotechnology

“…Based on the results of this study, it can be concluded that the nanostructured lipid carrier system with solid lipid poloxamer and stearic acid with liquid soybean oil lipids obtained good characteristics, and each test was in accordance with the range (Rochman, Darmawan, and Wardhana 2022).…”

“…The nanostructured lipid carrier (NLC) system is the development of a carrier system based on Solid Lipid Nanoparticles, which has the weakness of a low diffusion rate resulting in a long release time, high water content resulting in crystallization in the system, and ultimately a decrease in the solubility and release of bioactive compounds. sudden (Rochman, Darmawan, and Wardhana 2022).…”

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“…A small Polydispersity Index (PDI) value indicates a narrow particle size distribution, meaning that the particle size is more uniform. Samples with a polydispersion index value close to 0 indicate monodispersion [17]. The monodispersion system shows a narrow particle size distribution which indicates that the monodispersion system has a good level of uniformity or is homogeneous.…”