Nanostructured liquid crystalline particle assisted delivery of 2,4-dichlorophenoxyacetic acid to weeds, crops and model plants

Nadiminti, Pavani P; Rookes, James; Dong, Yao; Sayer, Chad; Boyd, Ben J.; Cahill, David M.

doi:10.1016/j.cropro.2015.12.018

Cited by 21 publications

(28 citation statements)

References 27 publications

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“…4 over the 3-dimensional spatial coordinates according to Eq. (14), whereas this quantity can be determined for the single-mode model directly from Eq. (12).…”

Section: ð1þmentioning

confidence: 99%

“…Hence controlled-release technology is currently studied in the agricultural, pharmaceutical, biomedical, and food industries as a potentially beneficial technology for herbicides, pharmaceuticals, fertilizers, and other targeted chemical applications. [9][10][11][12][13][14] Chemically loaded nanosphere materials are actively being researched as controlled release carriers because of their high specific surface area and nanoporous structure; [15][16][17][18][19][20][21][22][23][24] hollow nanosphere materials are particularly interesting because they exhibit a very high chemical loading capacity and allow for efficient transport into and out of their hollow interior cores. [25][26][27][28][29][30] Modelling diffusion through these hollow nanoporous materials has thus become a critical subject in advancing this new technology so that a complete understanding can be gained of the physiochemical mechanisms that control the chemical transport through the nanosphere walls, based on relevant parameters such as shell thickness and porosity.…”

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confidence: 99%

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Accuracy of the Single-mode Model of Controlled Release from Hollow Porous Nanospheres

Edwards¹,

Wang²,

Edwards³

et al. 2018

Eng. Sci.

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The kinetics of diffusion-controlled release from hollow nanoporous spheres of varying thickness were recently investigated using classical mass transport theory. A new model, expressed in terms of a single diffusive mode, was developed to describe the time-dependent mass transport of a loaded chemical species through the nanosphere shell based on physically reasonable boundary and initial conditions, as well as an assumption of monotonicity during the approach to steady-state diffusive behavior. The purpose of this communication is to demonstrate the validity of these assumptions in the long-time limit and to estimate the error associated with the short-time transport. To this end, the kinetics of the single-mode model are compared with a full solution to the time-dependent diffusion equation obtained using numerical techniques, which demonstrates the utility of the single-mode model for all but the initial moments of the transport process. As a result, it is evident that the single-mode model, which expresses the diffusion of the solute from the nanospheres in terms of a single, universal time constant, is a valid approximate model for describing diffusion in these nanoporous systems for controlled release applications.

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“…4 over the 3-dimensional spatial coordinates according to Eq. (14), whereas this quantity can be determined for the single-mode model directly from Eq. (12).…”

Section: ð1þmentioning

confidence: 99%

mentioning

confidence: 99%

Accuracy of the Single-mode Model of Controlled Release from Hollow Porous Nanospheres

Edwards¹,

Wang²,

Edwards³

et al. 2018

Eng. Sci.

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“…The biological activity of herbicides depends to a large extent on their concentration and exposure time. Recently, nanostructured liquid crystalline particles have been applied as delivery vehicle for 2,4-D (Nadiminti et al 2016). Herein, we propose a method for obtaining hybrid materials consisting of QuadraPure™ polymer-based spherical scavengers and the herbicide (2,4-D or MCPA).…”

Section: Introductionmentioning

confidence: 99%

Functionalized polystyrene beads as carriers in release studies of two herbicides: 2,4-dichlorophenoxyacetic acid and 2-methyl-4-chlorophenoxyacetic acid

Olejnik

Nowak

Schroeder

2018

Int. J. Environ. Sci. Technol.

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The extensive usage of pesticides in agriculture has adverse effect on the quality of water and soil; therefore, the proper dosage is of great concern. The aim of this study was to use the functionalized polystyrene beads (QuadraPure™) as a reservoir for the storage and controlled release of two herbicides: 2,4-dichlorophenoxyacetic acid and 2-methyl-4-chlorophenoxyacetic acid. It was proved that desorption of herbicides was strongly affected by the surface properties of polystyrene beads characterized by different pore size distributions and modified with various functional groups. We suggest that the optimal hybrid systems are the mixtures that are able to release the high amount of herbicides for a long time. For 2,4-dichlorophenoxyacetic acid, these conditions were fulfilled by polystyrene beads with the attached imino diacetate or thiourea functional groups. For 2-methyl-4-chlorophenoxyacetic acid, the appropriate results were obtained when polystyrene beads with the thiourea functional groups were applied. Additionally, QuadraPure™ scavengers could form stable complexes with copper and nickel ions, and therefore, the pesticide release was limited. The application of a hybrid system permitted to control the distribution of the herbicide by the formation of complexes between metal ions and organic groups of QuadraPure™ materials. The results proved that by using the polystyrene beads the release of herbicide could be controlled.

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“…Also, MSNs were shown to be able to deliver the herbicide 2,4-dichlorophenoxyacetic acid (2,4-D) to control the growth of model weeds while simultaneously reducing soil contamination [ 11 ]. In our recent work, lyotropic liquid crystalline (LC) phases were shown in laboratory and field studies to minimise crop phytotoxicity while efficiently delivering 2,4-D to eliminate weeds [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

“…Such LC systems have recently been of interest also for the delivery of agrochemical actives to plants. LC systems in inverse bicontinuous cubic phase structure can interact with hydrophobic plant surfaces, prevent crop phytotoxicity and reduce off target toxicity effects [ 12 , 17 ]. In field trials the practical use of a surfactant free LC system for the delivery of 2,4-D to kill wild radish ( Raphanus raphanistrum ) in a wheat ( Triticum aestivum ) crop was demonstrated [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

Novel self-assembling conjugates as vectors for agrochemical delivery

et al. 2018

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BackgroundModern agricultural practises rely on surfactant-based spray applications to eliminate weeds in crops. The wide spread and indiscriminate use of surfactants may result in a number of deleterious effects that are not limited to impacts on the crop and surrounding farm eco-system but include effects on human health. To provide a safer alternative to the use of surfactant-based formulations, we have synthesised a novel, self-assembling herbicide conjugate for the delivery of a broad leaf herbicide, picloram.ResultsThe synthesized self-assembling amphiphile–picloram (SAP) conjugate has three extending arms: a lipophilic lauryl chain, a hydrophilic polyethylene glycol chain and the amphiphobic agrochemical active picloram. We propose that the SAP conjugate maintains its colloidal stability by quickly transitioning between micellar and inverse micellar phases in hydrophilic and lipophilic environments respectively. The SAP conjugate provides the advantage of a phase structure that enables enhanced interaction with the hydrophobic epicuticular wax surface of the leaf. We have investigated the herbicidal efficiency of the SAP conjugate compared against that of commercial picloram formulations using the model plant Arabidopsis thaliana and found that when tested at agriculturally relevant doses between 0.58 and 11.70 mM a dose-dependent herbicidal effect with comparable kill rates was evident.ConclusionThough self-assembling drug carriers are not new to the pharmaceutical industry their use for the delivery of agrochemicals shows great promise but is largely unexplored. We have shown that SAP may be used as an alternative to current surfactant-based agrochemical formulations and has the potential to shift present practises towards a more sustainable approach.Electronic supplementary materialThe online version of this article (10.1186/s12951-018-0423-5) contains supplementary material, which is available to authorized users.

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Nanostructured liquid crystalline particle assisted delivery of 2,4-dichlorophenoxyacetic acid to weeds, crops and model plants

Cited by 21 publications

References 27 publications

Accuracy of the Single-mode Model of Controlled Release from Hollow Porous Nanospheres

Accuracy of the Single-mode Model of Controlled Release from Hollow Porous Nanospheres

Functionalized polystyrene beads as carriers in release studies of two herbicides: 2,4-dichlorophenoxyacetic acid and 2-methyl-4-chlorophenoxyacetic acid

Novel self-assembling conjugates as vectors for agrochemical delivery

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