Nanostructured N/S doped carbon dots/mesoporous silica nanoparticles and PVA composite hydrogel fabrication for anti-microbial and anti-biofilm application

Pongchaikul, Pisut; Hajidariyor, Tasnim; Khetlai, Navarat; Yu, Yu-Sheng; Arjfuk, Pariyapat; Khemthong, Pongtanawat; Wanmolee, Wanwitoo; Posoknistakul, Pattaraporn; Laosiripojana, Navadol; Wu, Kevin C.-W.; Sakdaronnarong, Chularat

doi:10.1016/j.ijpx.2023.100209

Cited by 2 publications

(3 citation statements)

References 81 publications

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“…109 Likewise, Pongchaikul et al in 2023 studied the anti-biofilm property of a N/S-doped CD/mesoporous silica nanoparticle (MSN) and poly(vinyl alcohol) (PVA) composite hydrogel and reported four times more efficiency of MSN nanocomposites in preventing biofilm formation compared to silver nanoparticles. 110 The authors suggested that ROS generated via a natural light-induced phenomenon led to bacterial biofilm destruction. In another study, CDs formed from dimethyl octadecyl- [3-(trimethoxysilyl)propyl] ammonium chloride (Si-QAC) with long alkyl chains were capable of selective eradication of Gram-positive bacterial biofilms via electrostatic and hydrophobic interactions.…”

Section: Carbon Dots In Biofilm Treatmentmentioning

confidence: 99%

“…Travlou et al in 2018 reported the antimicrobial efficiency of N- and S-doped CDs synthesized from poly(sodium-4-styrene sulfonate) or polyvinylpyrrolidone, because of chemical interaction between the CD surface electrostatic charge and the bacterial cell membrane . Likewise, Pongchaikul et al in 2023 studied the anti-biofilm property of a N/S-doped CD/mesoporous silica nanoparticle (MSN) and poly(vinyl alcohol) (PVA) composite hydrogel and reported four times more efficiency of MSN nanocomposites in preventing biofilm formation compared to silver nanoparticles . The authors suggested that ROS generated via a natural light-induced phenomenon led to bacterial biofilm destruction.…”

Section: Carbon Dots In Biofilm Treatmentmentioning

confidence: 99%

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Biofilm Inhibition on Medical Devices and Implants Using Carbon Dots: An Updated Review

Priyadarshini,

Kumar,

Balakrishnan

et al. 2024

ACS Appl. Bio Mater.

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Biofilms are an intricate community of microbes that colonize solid surfaces, communicating via a quorum-sensing mechanism. These microbial aggregates secrete exopolysaccharides facilitating adhesion and conferring resistance to drugs and antimicrobial agents. The escalating global concern over biofilm-related infections on medical devices underscores the severe threat to human health. Carbon dots (CDs) have emerged as a promising substrate to combat microbes and disrupt biofilm matrices. Their numerous advantages such as facile surface functionalization and specific antimicrobial properties, position them as innovative anti-biofilm agents. Due to their minuscule size, CDs can penetrate microbial cells, inhibiting growth via cytoplasmic leakage, reactive oxygen species (ROS) generation, and genetic material fragmentation. Research has demonstrated the efficacy of CDs in inhibiting biofilms formed by key pathogenic bacteria such as Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa. Consequently, the development of CD-based coatings and hydrogels holds promise for eradicating biofilm formation, thereby enhancing treatment efficacy, reducing clinical expenses, and minimizing the need for implant revision surgeries. This review provides insights into the mechanisms of biofilm formation on implants, surveys major biofilm-forming pathogens and associated infections, and specifically highlights the anti-biofilm properties of CDs emphasizing their potential as coatings on medical implants.

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Section: Carbon Dots In Biofilm Treatmentmentioning

confidence: 99%

Section: Carbon Dots In Biofilm Treatmentmentioning

confidence: 99%

Biofilm Inhibition on Medical Devices and Implants Using Carbon Dots: An Updated Review

Priyadarshini,

Kumar,

Balakrishnan

et al. 2024

ACS Appl. Bio Mater.

View full text Add to dashboard Cite

show abstract

“…In recent years, carbon dots (CDs) have emerged as compelling substances in tracking, labeling, and visualization applications owing to their excellent fluorescent properties and ultrasmall size. , For instance, Pongchaikul et al prepared nitrogen–sulfur-doped CDs (NS/CDs) coupled with mesoporous silica nanostructure (MSN) composite nanoparticles and filled them into the PVA hydrogel. The antibacterial properties of NS/CDs-MSN are 4 times higher than those of traditional silver nanoparticles and are cost-effective.…”

Section: Introductionmentioning

confidence: 99%

Robust Fluorescent Silica/Polyethylene Glycol Hydrogel Membrane for Tracking and Antifouling

Ma,

Qi,

Chen

et al. 2024

ACS Appl. Polym. Mater.

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Until now, traditional hydrogels have no long-term application in ship antifouling owing to their poor mechanical properties. Herein, the synergetic application strategy of nitrogen-doped carbon dots loaded silica (SiO 2 @N-CDs) nanoparticles to enhance polyethylene glycol (PEG) hydrogel membrane was proposed. The incorporation of SiO 2 @N-CDs improves the water retention and mechanical properties of the hydrogel. Importantly, the SiO 2 @N-CDs/PEG hydrogel exhibits remarkable antiadhesion capacity against bacteria, showing excellent antifouling performance. Fluorescence distribution analysis indicates alterations in the surface and fracture morphology of the hydrogel owing to SiO 2 @ N-CDs, with a "twill-fold" change in fracture. In addition, molecular dynamics simulations show that SiO 2 enhances the hydration layer of the hydrogel, contributing to its enhanced water retention effect. These findings provide avenues for the development of ship antifouling materials.

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Nanostructured N/S doped carbon dots/mesoporous silica nanoparticles and PVA composite hydrogel fabrication for anti-microbial and anti-biofilm application

Cited by 2 publications

References 81 publications

Biofilm Inhibition on Medical Devices and Implants Using Carbon Dots: An Updated Review

Biofilm Inhibition on Medical Devices and Implants Using Carbon Dots: An Updated Review

Robust Fluorescent Silica/Polyethylene Glycol Hydrogel Membrane for Tracking and Antifouling

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