Nanostructured SnO2 integrated conductive fabrics as binder-free electrode for neurotransmitter detection

Madhu, Sekar; Manickam, Pandiaraj; Pierre, Michelle; Bhansali, Shekhar; Ponpandian, N.; Viswanathan, C.

doi:10.1016/j.sna.2017.11.046

Cited by 25 publications

(15 citation statements)

References 61 publications

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“…As a reference, nanostructured SnO 2 integrated conductive carbon yarns were developed as binder‐free electrodes for the detection of neurotransmitters, which can be further developed as wearable electrochemical sensors. [ 234 ] However, to the best of our knowledge, TMOs have not yet been developed as wearable devices for the in vivo detection of neurotransmitters, and this opens up a new area of research for scientists all over the world.…”

Section: Future Perspectives Of Electrochemical Detection Of Neurotransmittersmentioning

confidence: 99%

Transition metal oxide based non‐enzymatic electrochemical sensors: An arising approach for the meticulous detection of neurotransmitter biomarkers

Poolakkandy

Menamparambath

2020

Electrochemical Science Adv

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Diagnosis of brain disorders is an extremely confronting task for the medical community and hence, the recognition and detection of pertinent biomarkers for neurological disorders is a crucial phase. Electrochemical techniques with transition metal oxide (TMOs) modified electrodes have emerged as a promising technique for the detection of neurotransmitters, which act as potent biomarkers. This review has tried to sum up the recent advancements made in the TMOs modified non-enzymatic electrochemical detection of important neurotransmitters in the last two decades. A comprehensive description of these neurotransmitters along with their biochemistry and impact on the human body is also provided. A short description of the future perspectives of the electrochemical detection of neurotransmitters is given highlighting the wearable sensors for the in vivo detection.

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Section: Future Perspectives Of Electrochemical Detection Of Neurotransmittersmentioning

confidence: 99%

Transition metal oxide based non‐enzymatic electrochemical sensors: An arising approach for the meticulous detection of neurotransmitter biomarkers

Poolakkandy

Menamparambath

2020

Electrochemical Science Adv

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“…In addition, weak peak around 1413 cm −1 roots in C-O deformation vibration, implying the existence of intramolecular hydrogen bonding between CCY and Fe-OH, which is beneficial in keeping the stability of material structure. A remarkable decrease in the absorption of C=O, O-H (deformation vibration) and the C-O groups were observed, proving that most of the oxygen containing groups were removed 31 . From the FT-IR results, we corroborate that the Fe 2 O 3 are covered to the CCY surface uniformly.…”

Section: Resultsmentioning

confidence: 97%

“…The crystal alignment gives the fiber high strength-to-volume ratio. Fiber materials have been widely applied in the field of electrochemistry and composite materials due to its intrinsic carrier mobility, electrical conductivity, environmental stability, superior mechanical properties, low weight and high temperature tolerance as well as potential for production at low cost 28 – 31 . Fabrics based on conductive fibers represent an excellent class of substrates for developing wearable sensors because they would be in constant contact with the skin 32 , 33 .…”

Section: Introductionmentioning

confidence: 99%

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Carbon fiber based electrochemical sensor for sweat cortisol measurement

Sekar

Manickam

Bhansali

et al. 2019

Sci Rep

120

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This study examines the use of a conductive carbon fiber to construct a flexible biosensing platform for monitoring biomarkers in sweat. Cortisol was chosen as a model analyte. Functionalization of the conductive carbon yarn (CCY) with ellipsoidal Fe2O3 has been performed to immobilize the antibodies specific to cortisol. 1-Ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC) and N-Hydroxysuccinimide (NHS) chemistry has been used to immobilize the antibodies onto the Fe2O3 modified CCY. Crystallinity, structure, morphology, flexibility, surface area, and elemental analysis were studied using X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR), Raman spectroscopy, Field emission scanning electron microscopy with energy dispersive X-ray spectroscopy (FE-SEM/EDS) and Brunauer–Emmett–Teller (BET) analysis. Mechanical properties of the fiber such as tensile strength, young’s modulus have also been investigated. Under optimal parameters, the fabric sensor exhibited a good linearity (r2 = 0.998) for wide a linear range from 1 fg to 1 μg with a detection limit of 0.005 fg/mL for the sensitive detection of cortisol. Repeatability, reliability, reproducibility, and anti-interference properties of the current sensor have been investigated. Detection of cortisol levels in human sweat samples has also been investigated and the results were validated with commercial chemiluminescence immunoassay (CLIA) method.

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“…The ZnONRs/CCY showed better mechanical properties compared to the Fe 2 O 3 /CCY and SnO 2 /CCY reported in our previous studies. 28,33 The superior mechanical stability and integrity of the CCY electrode can be beneficial for wearable sensor platforms. The electrical conductivity of the ZnONRs/ CCY was also calculated by using a four-probe method, and the results are presented in Figure S3.…”

Section: ■ Materials and Methodsmentioning

confidence: 99%

ZnO Nanorod Integrated Flexible Carbon Fibers for Sweat Cortisol Detection

Madhu

Anthuuvan

Ramasamy

et al. 2020

ACS Appl. Electron. Mater.

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Sensors fabricated on fabrics provide an elevated ease of use for wearable sensors. Such sensors will play a critical role in detecting the elevations in the concentrations of biochemical markers in human sweat. The ability of making such measurements is becoming an important tool for non-invasive and real-time health monitoring. We present a yarn-based flexible and superwettable electrochemical immunosensing strategy for highly selective and sensitive detection of cortisol in sweat. ZnO nanorods (ZnONRs)-coated flexible carbon yarns were prepared by using a hydrothermal method for immobilizing specific anti-cortisol antibodies and used as an immunosensing platform for detecting sweat cortisol levels. The morphology, elemental composition, crystallinity, and specific surface area were analyzed by using analytical techniques such as transmission electron microscopy (TEM), field emission scanning electron microscopy coupled energy-dispersive X-ray analysis (FE-SEM/EDS), X-ray diffraction (XRD), fourier-transform infrared spectroscopy (FT-IR), Raman spectroscopy, and Brunauer–Emmett–Teller (BET) analysis. The ZnONRs integrated carbon yarns showed excellent mechanical stability and superwettable properties. The immunosensor exhibited a wide linear detection range from 1 fg/mL to 1 μg/mL. The detection limits of the immunosensor were calculated to be between 0.45 and 0.098 fg/mL by using CV and DPV techniques, respectively. Additionally, cell viability studies were performed to investigate the biocompatibility and cytotoxicity of this carbon yarn ZnO sensing platform. The immunosensor was applied to measure the cortisol concentration in human sweat samples, and the outcomes were validated by using a chemiluminescent immunoassay system.

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Nanostructured SnO2 integrated conductive fabrics as binder-free electrode for neurotransmitter detection

Cited by 25 publications

References 61 publications

Transition metal oxide based non‐enzymatic electrochemical sensors: An arising approach for the meticulous detection of neurotransmitter biomarkers

Transition metal oxide based non‐enzymatic electrochemical sensors: An arising approach for the meticulous detection of neurotransmitter biomarkers

Carbon fiber based electrochemical sensor for sweat cortisol measurement

ZnO Nanorod Integrated Flexible Carbon Fibers for Sweat Cortisol Detection

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