Nanostructures and hydrophilicity influence osseointegration: a biomechanical study in the rabbit tibia

Wennerberg, Ann; Jimbo, Ryo; Stübinger, Stefan; Obrecht, Marcel; Dard, Michel; Berner, Simon

doi:10.1111/clr.12213

Cited by 141 publications

(151 citation statements)

References 23 publications

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“…Moderately microroughness surface have proven to be superior to smooth counterparts (8,9), improving parameters as bone-implant contact, new bone formation and removal torque (11,12). Surface chemistry is also an important characteristic for implant performance since its affects on surface energy and wettability (5,7).…”

Section: Introductionmentioning

confidence: 99%

Influence of Implant Surfaces on Osseointegration: A Histomorphometric and Implant Stability Study in Rabbits

et al. 2015

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The aim of this study was to evaluate the stability and osseointegration of implant with different wettability using resonance frequency analysis (RFA) and histomorphometric analysis (bone implant contact, BIC; and bone area fraction occupied, BAFO) after 2 and 4 weeks in rabbit tibiae. Thirty-two Morse taper implants (length 7 mm, diameter 3.5 mm) were divided according to surface characteristics (n=8): Neo, sandblasted and dual acidetched; and Aq, sandblasted followed by dual acid-etched and maintained in an isotonic solution of 0.9% sodium chloride. Sixteen New Zealand rabbits were used. Two implants of each group were installed in the right and left tibiae according to the experimental periods. The RFA (Ostell®) was obtained immediately and after the sacrifice (2 and 4 weeks). The bone/implant blocks were processed for histomorphometric analysis. Data were analyzed using two-way ANOVA followed by Tukey's test and Pearson's correlation for ISQ, BIC and BAFO parameters (p=0.05). No significant effect of implant, period of evaluation or interaction between implant and period of evaluation was found for BIC and BAFO values (p>0.05). Only period of evaluation had significant effect for RFA values at 4 weeks (p=0.001), and at 2 weeks (p<0.001). RFA values were significantly higher at the final period of evaluation compared with those obtained at early periods. There was a significant correlation between BIC values and BAFO values (p=0.009). Both implant surfaces, Aq and Neo, were able to produce similar implant bone integration when normal cortical bone instrumentation was performed. Influence of Implant Surfaces o n O s s e o i n t e g r a t i o n : A Histomorphometric and Implant S t a b i l i t y S t u d y i n R a b b i t s

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Section: Introductionmentioning

confidence: 99%

Influence of Implant Surfaces on Osseointegration: A Histomorphometric and Implant Stability Study in Rabbits

et al. 2015

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“…In addition to three white novel titanium-based surfaces, Ticer, a clinically used surface, was employed in the previously reported study. In order to find out whether chemical composition of dental implant surfaces affects osteoblast differentiation, Ti-SLA, Ti-SLActive and TiZr-SLActive (all rough; Ra = 1.5, 1.6 and 1.6 µ m, respectively) [68,69] materials, as well as Cercon (smooth; Ra < 0.2 µ m), zirconia material, were selected for the present study. Ti cp (smooth; Ra < 0.2 µ m) and Ticer (rough; Ra = 1.4 µ m) [22] titaniumbased surfaces (investigated previously) [12], served as controls.…”

Section: Discussionmentioning

confidence: 99%

Ti-SLActive and TiZr-SLActive Dental Implant Surfaces Promote Fast Osteoblast Differentiation

et al. 2017

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A primary goal in modern surface modification technology of dental implants is to achieve biocompatible surfaces with rapid but controlled healing which also allow health and longevity of implants. In order to realize all, understanding of osseointegration phenomena is crucial. Although Ti-SLA, Ti-SLActive and TiZr-SLActive surfaces have been successfully used in clinical implantology and were shown to notably reduce the primary healing time, available in vitro studies are sparse and do not concern or explore the mechanism(s) involved in human osteoblast behavior on these surfaces. Ti-SLA, Ti-SLActive, TiZr-SLActive, Ti cp, Ticer and Cercon surfaces were used. Osteoblast proliferation, cell cluster formation, morphological changes, induction of autophagy, nitric oxide (NO), reactive oxygen species/reactive nitrogen species (ROS/RNS) formation, osteocalcin (OC), bone sialoprotein (BSP) and collagen type I (Col-1) affected by various surfaces were analyzed. These surfaces induced formation of mature osteoblasts caused by elevated oxidative stress (ROS) followed by overexpression of osteoblast maturation key molecule (NO), with different intensity however. These mature osteoblasts induced upregulation of OC, BSP and Col-1, activating PI3/Akt signalling pathway resulting in autophagy, known as an important process in differentiation of osteoblast cells. Additional distinctive subpopulation identified on Ticer, Ti-SLA (after 5 days), Ti-SLActive and TiZr-SLActive surfaces (after 2 days) were forming cell clusters, essential for bone noduli formation and mineralisation. The results suggest that Ti-and TiZr-SLActive possess advanced properties in comparison with Ticer and Ti-SLA manifested as accelerated osteoblast differentiation. These effects could explain already known fast osseointegration of these surfaces in vivo.

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“…Surface modification at the nanolevel has been reported in a number of studies to play a crucial role in osseointegration. [1][2][3][4][5][6][7][8][9][10][11][12] A new strategy to improve osseointegration is biochemical stimulation by developing surface nanocoating, which is able to increase adhesion of bone cells, bone matrix formation, and mineralization at the implant surface.…”

Section: Introductionmentioning

confidence: 99%

Nanocoating with plant-derived pectins activates osteoblast response in vitro

Folkert¹,

Meresta²,

Gaber³

et al. 2016

IJN

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Nanostructures and hydrophilicity influence osseointegration: a biomechanical study in the rabbit tibia

Abstract: The strongest bone response was achieved with a combination of wettability and the presence of nanostructures (SLActive).

Cited by 141 publications

References 23 publications

Influence of Implant Surfaces on Osseointegration: A Histomorphometric and Implant Stability Study in Rabbits

Influence of Implant Surfaces on Osseointegration: A Histomorphometric and Implant Stability Study in Rabbits

Ti-SLActive and TiZr-SLActive Dental Implant Surfaces Promote Fast Osteoblast Differentiation

Nanocoating with plant-derived pectins activates osteoblast response in vitro

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