Nanostructures of an amphiphilic zinc phthalocyanine polymer conjugate for photodynamic therapy of psoriasis

Jin, Yiguang; Zhang, Xiaohan; Zhang, Baolei; Kang, Hongxiang; Du, Lina; Li, Miao

doi:10.1016/j.colsurfb.2015.02.038

Cited by 52 publications

(30 citation statements)

References 25 publications

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“…Hydrophobic PSs also tend to remain longer in the patient’s body compared to hydrophilic PSs. These observations have caused PSs with amphiphilic properties through conjugation with water soluble or amphiphilic polymers or colloidal administrations to become attractive in PDT studies [43,44,45,46,47]. …”

Section: Ps Uptake and Selectivitymentioning

confidence: 99%

Developments in PDT Sensitizers for Increased Selectivity and Singlet Oxygen Production

2015

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Photodynamic therapy (PDT) is a minimally-invasive procedure that has been clinically approved for treating certain types of cancers. This procedure takes advantage of the cytotoxic activity of singlet oxygen (1O2) and other reactive oxygen species (ROS) produced by visible and NIR light irradiation of dye sensitizers following their accumulation in malignant cells. The main two concerns associated with certain clinically-used PDT sensitizers that have been influencing research in this arena are low selectivity toward malignant cells and low levels of 1O2 production in aqueous media. Solving the selectivity issue would compensate for photosensitizer concerns such as dark toxicity and aggregation in aqueous media. One main approach to enhancing dye selectivity involves taking advantage of key methods used in pharmaceutical drug delivery. This approach lies at the heart of the recent developments in PDT research and is a point of emphasis in the present review. Of particular interest has been the development of polymeric micelles as nanoparticles for delivering hydrophobic (lipophilic) and amphiphilic photosensitizers to the target cells. This review also covers methods employed to increase 1O2 production efficiency, including the design of two-photon absorbing sensitizers and triplet forming cyclometalated Ir(III) complexes.

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Section: Ps Uptake and Selectivitymentioning

confidence: 99%

Developments in PDT Sensitizers for Increased Selectivity and Singlet Oxygen Production

2015

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“…In fact, the singlet oxygen and other reactive species can destroy microorganisms and cancer cells [19][20][21]. For example, PDT has also been applied for bacterial, fungal, parasitic, and viral infections [22][23][24][25][26][27][28][29][30], age-related macular degeneration [31], oral diseases [32][33][34][35], and in the treatment of skin diseases such as acne vulgaris, cutaneous leishmaniasis, psoriasis, and papilloma virus infections [36][37][38][39][40][41][42][43]. Another interesting property of porphyrins are their photoinduced fluorescence and phosphorescence, explored in diagnosis by fluorescence tracking and imaging.…”

Section: Introductionmentioning

confidence: 99%

Porphyrin Derivative Nanoformulations for Therapy and Antiparasitic Agents

et al. 2020

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Porphyrins and analogous macrocycles exhibit interesting photochemical, catalytic, and luminescence properties demonstrating high potential in the treatment of several diseases. Among them can be highlighted the possibility of application in photodynamic therapy and antimicrobial/antiparasitic PDT, for example, of malaria parasite. However, the low efficiency generally associated with their low solubility in water and bioavailability have precluded biomedical applications. Nanotechnology can provide efficient strategies to enhance bioavailability and incorporate targeted delivery properties to conventional pharmaceuticals, enhancing the effectiveness and reducing the toxicity, thus improving the adhesion to the treatment. In this way, those limitations can be overcome by using two main strategies: (1) Incorporation of hydrophilic substituents into the macrocycle ring while controlling the interaction with biological systems and (2) by including them in nanocarriers and delivery nanosystems. This review will focus on antiparasitic drugs based on porphyrin derivatives developed according to these two strategies, considering their vast and increasing applications befitting the multiple roles of these compounds in nature.

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“…From a chemical point of view, PEG chains have proved to enhance the solubility in a variety of solvents, including nonpolar ones, aprotic polar solvents like DMSO, and protic polar solvents such as water [14,15]. Several Pcs functionalized with PEG chains of different length as peripheral [13,[15][16][17] or axial groups [18,19] have shown solubility in biological media, and some of them have been studied as PS for PDT [20,21].…”

Section: Introductionmentioning

confidence: 99%

Assessing Amphiphilic ABAB Zn(II) Phthalocyanines with Enhanced Photosensitization Abilities in In Vitro Photodynamic Therapy Studies Against Cancer

et al. 2020

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We have previously demonstrated that singlet oxygen photosensitization abilities of Zn(II) phthalocyanines (Zn(II)Pcs) are enhanced through α-functionalization with bulky fluorinated substituents (i.e., bis(trifluoromethyl)phenyl units) at facing positions of ABAB Zn(II)Pcs, where A and B refer to differently functionalized isoindoles. In this work, we have prepared the Zn(II)Pc ABAB 1 endowed with hydrophilic triethylene glycol monomethyl ether (i.e., at the A isoindoles) to provide solubility in aqueous media, together with its A3B and A4 counterparts, and compared their ability to behave as photosensitizers for photodynamic therapy. All photophysical data, aggregation studies and preliminary in vitro biological assays in cell cultures of SCC-13 (squamous cell carcinoma) and HeLa (cervical cancer cells), have proved ABAB 1 as the best photosensitizer of the series.

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Nanostructures of an amphiphilic zinc phthalocyanine polymer conjugate for photodynamic therapy of psoriasis

Cited by 52 publications

References 25 publications

Developments in PDT Sensitizers for Increased Selectivity and Singlet Oxygen Production

Developments in PDT Sensitizers for Increased Selectivity and Singlet Oxygen Production

Porphyrin Derivative Nanoformulations for Therapy and Antiparasitic Agents

Assessing Amphiphilic ABAB Zn(II) Phthalocyanines with Enhanced Photosensitization Abilities in In Vitro Photodynamic Therapy Studies Against Cancer

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