Nanosuspensions as an approach for improved solubility and anti-Ichthyophthirius multifiliis activity of magnolol

Liu, Jietao; Qu, Shenye; Wang, Tao; Yang, Bin; Liu, Xiang; Wang, Gaoxue; Li, Pengfei; Yu, Qing; Ling, Fei

doi:10.1016/j.aquaculture.2023.740133

Aquaculture

2024

DOI: 10.1016/j.aquaculture.2023.740133

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Nanosuspensions as an approach for improved solubility and anti-Ichthyophthirius multifiliis activity of magnolol

Jietao Liu,

Shenye Qu,

Tao Wang

et al.

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Cited by 3 publications

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Immunotoxic response of bio-based plastic on early life stage zebrafish (Danio rerio): A safe alternative to petroleum-based plastics?

Cheng,

Zou,

et al. 2024

Journal of Hazardous Materials

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Immunotoxic response of bio-based plastic on early life stage zebrafish (Danio rerio): A safe alternative to petroleum-based plastics?

Cheng,

Zou,

et al. 2024

Journal of Hazardous Materials

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Zein decorated rifaximin nanosuspension: approach for sustained release and anti-bacterial efficacy enhancement

Mourya,

Handa,

Singh

et al. 2024

Therapeutic Delivery

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Key Challenges, Influencing Factors, and Future Perspectives of Nanosuspensions in Enhancing Brain Drug Delivery

Wang,

Yang,

Xue

et al. 2024

CPD

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Many brain diseases pose serious challenges to human life. Alzheimer's Disease (AD) and Parkinson's Disease (PD) are common neurodegenerative diseases that seriously threaten human health. Glioma is a common malignant tumor. However, drugs cannot cross physiological and pathological barriers and most therapeutic drugs cannot enter the brain because of the presence of the Blood-brain Barrier (BBB) and Blood- -brain Tumor Barrier (BBTB). How to enable drugs to penetrate the BBB to enter the brain, reduce systemic toxicity, and penetrate BBTB to exert therapeutic effects has become a challenge. Nanosuspension can successfully formulate drugs that are difficult to dissolve in water and oil by using surfactants as stabilizers, which is suitable for the brain target delivery of class II and IV drugs in the Biopharmaceutical Classification System (BCS). In nanosuspension drug delivery systems, the physical properties of nanostructures have a great impact on the accumulation of drugs at the target site, such as the brain. Optimizing the physical parameters of the nanosuspension can improve the efficiency of brain drug delivery and disease treatment. Therefore, the key challenges, influencing factors, and future perspectives of nanosuspension in enhancing brain drug delivery are summarized and reviewed here. This article aims to provide a better understanding of nanosuspension formulation technology used for brain delivery and strategies used to overcome various physiological barriers.

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Nanosuspensions as an approach for improved solubility and anti-Ichthyophthirius multifiliis activity of magnolol

Cited by 3 publications

References 58 publications

Immunotoxic response of bio-based plastic on early life stage zebrafish (Danio rerio): A safe alternative to petroleum-based plastics?

Immunotoxic response of bio-based plastic on early life stage zebrafish (Danio rerio): A safe alternative to petroleum-based plastics?

Zein decorated rifaximin nanosuspension: approach for sustained release and anti-bacterial efficacy enhancement

Key Challenges, Influencing Factors, and Future Perspectives of Nanosuspensions in Enhancing Brain Drug Delivery

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