Nanosystems in Cardiovascular Medicine: Advancements, Applications, and Future Perspectives

Omidian, Hossein; Babanejad, Niloofar; Cubeddu, Luigi X.

doi:10.3390/pharmaceutics15071935

Cited by 14 publications

(4 citation statements)

References 96 publications

(188 reference statements)

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“…Additionally, several antiarrhythmic drugs have been coupled to NPs and have shown to be of therapeutic benefit, including liposomal amiodarone-loaded NPs, which show enhanced ischemic/perfused myocardial site selectivity and efficacy. Consequently, this has reduced mortality from lethal arrhythmias while avoiding the negative hemodynamic effects of amiodarone use in such patients [ 101 , 102 ].…”

Section: Nanoparticles For Drug Deliverymentioning

confidence: 99%

Tailoring Treatment in Cardiovascular Diseases: The Role of Targeted Therapies

Dankar,

Wehbi,

Refaat

2024

Pharmaceutics

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Cardiovascular diseases (CVDs) remain the leading cause of morbidity and mortality around the globe. To address this public health burden, innovative therapeutic agents are being developed to specifically target molecular and genetic markers. Various therapeutic modalities have been implemented, including vaccines, monoclonal or bispecific antibodies, and gene-based therapies. Such drugs precisely target the underlying disease pathophysiology, aiming at notable molecules such as lipid metabolism regulators, proinflammatory cytokines, and growth factors. This review focuses on the latest advancements in different targeted therapies. It provides an insightful overview of the current landscape of targeted cardiovascular therapies, highlighting promising strategies with potential to transform the treatment of CVDs into an era of precision medicine.

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Section: Nanoparticles For Drug Deliverymentioning

confidence: 99%

Tailoring Treatment in Cardiovascular Diseases: The Role of Targeted Therapies

Dankar,

Wehbi,

Refaat

2024

Pharmaceutics

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“…Iron oxide magnetic nanoparticles (IONPs) have gained significant attention as theranostic agents in a range of biomedical applications, including the treatment of cardiovascular diseases. (1)(2)(3)(4)(5) The versatility of IONPs enables precise magnetic manipulation, drug delivery, imaging, and therapeutic interventions at both the cellular and molecular level, addressing the complex challenges posed by cardiovascular disorders. (3,(6)(7)(8) Given their biocompatibility (9) and superparamagnetic properties, IONPs are primarily employed as contrast agents in magnetic resonance imaging (MRI) even in microvasculature, enhancing diagnostic capabilities.…”

Section: Introductionmentioning

confidence: 99%

“…(1)(2)(3)(4)(5) The versatility of IONPs enables precise magnetic manipulation, drug delivery, imaging, and therapeutic interventions at both the cellular and molecular level, addressing the complex challenges posed by cardiovascular disorders. (3,(6)(7)(8) Given their biocompatibility (9) and superparamagnetic properties, IONPs are primarily employed as contrast agents in magnetic resonance imaging (MRI) even in microvasculature, enhancing diagnostic capabilities. (10,11) (2,12,13) Furthermore, the utilization of IONPs in photothermal therapy has gained popularity, particularly in the context of obstructive diseases associated with blood clotting and thromboembolic events.…”

Section: Introductionmentioning

confidence: 99%

Assessing the effect of iron oxide magnetic nanoflowers on blood components in a multi-scale approach in the context of thromboembolic disease

Colombo,

Meng,

Poirier-Quinot

et al. 2024

Preprint

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Iron oxide magnetic nanoparticles have emerged as promising theranostic agents for cardiovascular diseases. Using a multiscale approach, we investigate the interaction of 27 nm diameter multicore magnetite nanoflowers with blood components. Using flow cytometry and dynamic light scattering, we determine safe magnetite nanoflowers concentration levels. Data indicates negligible impact on red blood cells and white blood cells for all concentrations and exposure durations studied, whilst platelets exhibit reversible activation at high magnetite nanoflowers concentrations. Magnetic resonance imaging reveals significant reductions in T1 and T2 relaxation times in platelets treated with magnetite nanoflowers at high concentrations, indicating efficient internalization. Additionally, transmission electron microscopy confirms morphological changes in platelets exposed to the iron oxide magnetic nanoparticles, indicating that internalization occurs via endocytosis. Overall, the findings support the theranostic utility of magnetite iron oxide nanoflowers in whole blood for thromboembolic disease management, with potential for future investigations over longer durations.

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“…NPs can be made from various chemical compositions, as a wide range of possible materials have been fabricated by researchers worldwide. Formulations based on polymeric, liposomal, inorganic, or hybrid nanomaterials have been increasingly investigated in recent years as emerging diagnosis and treatment options for various diseases [4,6,7,[9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Metal-Based Nanoparticles for Cardiovascular Diseases

Scafa Udriște,

Burdușel,

Niculescu

et al. 2024

IJMS

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Globally, cardiovascular diseases (CVDs) are the leading cause of death and disability. While there are many therapeutic alternatives available for the management of CVDs, the majority of classic therapeutic strategies were found to be ineffective at stopping or significantly/additionally slowing the progression of these diseases, or they had unfavorable side effects. Numerous metal-based nanoparticles (NPs) have been created to overcome these limitations, demonstrating encouraging possibilities in the treatment of CVDs due to advancements in nanotechnology. Metallic nanomaterials, including gold, silver, and iron, come in various shapes, sizes, and geometries. Metallic NPs are generally smaller and have more specialized physical, chemical, and biological properties. Metal-based NPs may come in various forms, such as nanoshells, nanorods, and nanospheres, and they have been studied the most. Massive potential applications for these metal nanomaterial structures include supporting molecular imaging, serving as drug delivery systems, enhancing radiation-based anticancer therapy, supplying photothermal transforming effects for thermal therapy, and being compounds with bactericidal, fungicidal, and antiviral qualities that may be helpful for cardiovascular diseases. In this context, the present paper aims to review the applications of relevant metal and metal oxide nanoparticles in CVDs, creating an up-to-date framework that aids researchers in developing more efficient treatment strategies.

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Nanosystems in Cardiovascular Medicine: Advancements, Applications, and Future Perspectives

Cited by 14 publications

References 96 publications

Tailoring Treatment in Cardiovascular Diseases: The Role of Targeted Therapies

Tailoring Treatment in Cardiovascular Diseases: The Role of Targeted Therapies

Assessing the effect of iron oxide magnetic nanoflowers on blood components in a multi-scale approach in the context of thromboembolic disease

Metal-Based Nanoparticles for Cardiovascular Diseases

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