Nanotechnologies for biomolecular detection and medical diagnostics

Cheng, Mark Ming Cheng; Cuda, Giovanni; Bunimovich, Yuri L.; Gaspari, Marco; Heath, James R.; Hill, Haley D.; Mirkin, Chad A.; Nijdam, A.J.; Terracciano, Rosa; Thundat, Thomas; Ferrari, Mauro

doi:10.1016/j.cbpa.2006.01.006

Cited by 436 publications

(265 citation statements)

References 33 publications

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“…concentration [1][2][3][4][5] instead of the linear dependence predicted from classical theory and observed in fluorescence measurements [9] (see the list of four puzzles in section I). Numerical solution of Eqs.…”

Section: To Our Knowledge This Is the First Theoretical Explanation Tmentioning

confidence: 96%

“…Functionalized Silicon Nanowire (Si-NW) devices have been used to demonstrate detection of DNA [1][2][3] and proteins [4][5] at very low concentrations (Fig. 1a).…”

Section: Introductionmentioning

confidence: 99%

“…2a, [1][2][3][4][5]), (ii) linear dependence on pH which is crucial for protein detection (Fig. 2b, [5,6]), (iii) non-linear dependence of sensitivity on electrolyte concentration (Fig.…”

Section: Introductionmentioning

confidence: 99%

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Screening-Limited Response of NanoBiosensors

2008

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ABSTRACT:Despite tremendous potential of highly sensitive electronic detection of bio-molecules by nanoscale biosensors for genomics and proteomic applications, many aspects of experimentally observed sensor response (S) are unexplained within consistent theoretical frameworks of kinetic response or electrical screening. In this paper, we combine analytic solutions of Poisson-Boltzmann and reaction-diffusion equations to show that the electrostatic screening within an ionic environment limits the response of nanobiosensor such that ( ) ( ) ( ) ( ) [ ]

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Section: To Our Knowledge This Is the First Theoretical Explanation Tmentioning

confidence: 96%

“…Functionalized Silicon Nanowire (Si-NW) devices have been used to demonstrate detection of DNA [1][2][3] and proteins [4][5] at very low concentrations (Fig. 1a).…”

Section: Introductionmentioning

confidence: 99%

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Screening-Limited Response of NanoBiosensors

2008

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“…[13] For example, nanomaterials-based detection methods utilizing lasers, nuclear magnetic resonance (NMR), fluorescence labeling, and even flow cytometry have been developed that allow for faster and more accurate TB detection. [14] The nanomaterial-based TB detection systems are discussed below.…”

Section: Nanomaterials In Tb Diagnosticsmentioning

confidence: 99%

Nanomaterials in the Prevention, Diagnosis, and Treatment of Mycobacterium Tuberculosis Infections

Liang

Ding

et al. 2017

Adv Healthcare Materials

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worldwide was estimated at a staggering 10.4 million, with a significant percentage (10%) resulting from concomitant HIV-TB coinfections. [1] Given the closely knitted association between TB infections and poor sanitation/poverty, it thus comes with no surprise that an overwhelming majority of disease burden (60%) is actually shouldered by countries from the developing world (Figure 1). [1] TB infections are compounded by the emergence of multidrug resistance (MDR). In spite of the tremendous amount of resources and research dollars that have been devoted to TB research, TB diagnostics and treatment outcomes still remain startlingly poor. TB remains worryingly underreported, under-diagnosed and undertreated. A 4.3 million gap was reported between incident and notified TB cases, chiefly in developing countries; majority of TB infections remain latent and unreported, and only 30% of new incident TB cases were subjected to drug susceptibility testing. [1] The Xpert Mycobacterium Tuberculosis (MTB)/RIF assay remains the only available WHOrecommended rapid diagnostic platform for detection of TB and drug (rifampicin) resistance. Treatment success rates are highly variable, ranging from 28% (extensively drug-resistant strains) to 83% (garden strains) of TB. The rate of decline in TB incidence has remained stagnant at 1.5% annually over the past decade, far lagging behind the 5% projected by the WHO's End TB Strategy. Against such a backdrop, TB remains firmly entrenched among the top 10 causes of death worldwide. [2] To this end, the WHO has since 2015, adopted the End TB Strategy in an effort to stem this burgeoning epidemic. Major diagnostic and treatment gaps in TB management still remain, and these need to be addressed to effectively curtail TB spread and its impact on global health. Pathogenesis of TB InfectionsMTB is the infectious agent responsible for TB infections. It originates from the family Mycobacteriaceae and is an obligate bacteria chiefly spread via air droplets.

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“…Microfluidic devices are increasingly used in biological experimentation due to their potential for miniaturization and automation. [2][3][4][5][6] A critical deficiency of current understanding in systems biology is a detailed thermodynamic description of the sequence specific recognition of DNA regulatory sites by transcription factors. Maerkl and Quake apply the MITOMI method to determine relative binding affinities as a function of DNA sequence of four eukaryotic basic helixloop-helix (bHLH) transcription factors (TF); namely, two human TFs-A and B isoforms of MAX, and two yeast TFs-Pho4p and Cbflp.…”

mentioning

confidence: 99%