The aim of this paper is to analyze the issues associated with the determination of parameters for stress and strain state of compression load-bearing elements in frame buildings. The paper highlights the main sources and causes of eccentricities, as well as the differences in the behavior of centrally and eccentrically loaded reinforced concrete elements. Particular attention was also paid to stress distributions both in cross-sectional and height direction of eccentrically loaded reinforced concrete elements depending on the eccentricity value. According to the conducted analysis, the functional efficiency of compression columns of the framework depends directly on initially set (designed) parameters of bearing capacity, technology and quality of implementation of corresponding construction processes. The formation of eccentricities and deviations of cross-section axes for framing columns is a consequence of insufficient design solutions (taking into account possible manifestations of the phenomena under consideration) and/or construction works. In order to consider eccentricities and axis deviations, the special algorithm should be developed to examine the actual parameters of the stress and strain state. Moreover, a set of measures should be introduced to increase the indicators of bearing capacity of columns for frameworks of multi-story buildings. The paper provides the analytical data which can be used in the development of guidelines for improving the bearing capacity for eccentrically loaded reinforced concrete columns of multi-story frame buildings.