Nanotechnology against COVID-19: Immunization, diagnostic and therapeutic studies

Hasanzadeh, Akbar; Alamdaran, Masoomeh; Ahmadi, Sepideh; Nourizadeh, Helena; Bagherzadeh, Mohammad Aref; Jahromi, Mirza Ali Mofazzal; Simon, Perikles; Karimi, Mahdi; Hamblin, Michael R.

doi:10.1016/j.jconrel.2021.06.036

Cited by 40 publications

(35 citation statements)

References 255 publications

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“…Many studies and research have appeared in recent years that dealt with the introduction of one of the most accurate techniques that are now frequented by our ears, which is nanotechnology.This very accurate technology is used in all areas of life including agricultural, medical and industrial sectors (Tahir et al 2021). Nanotechnology has a lot of inventions in the biological and medical fields, sustainable water treatment (Tom 2021), studying the primary components of cells, and knowing their properties, using magnifying microscopes, as well as in the pharmaceutical industry (Sahu et al 2021), microscopic injection, study of DNA, and pandemic diseases like COVID-19 (Hasanzadeh et al 2021).…”

Section: Resultsmentioning

confidence: 99%

Bio-Nano Fertilizers Preparation Using a Fully-Automated Apparatus: A Case Study of Nano-Selenium

El-Ghamry

El-Khateeb

Mosa

et al. 2021

EBSS

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T HE global production of mineral fertilizers suffers from several critics due the serious problems, which penetrated the environment causing direct and indirect troubles for human health. Thus, the sustainable alternative "like bio-nanofertilizers" for the mineral fertilizers, that protects and conserves the environment will be a global aim. The present investigation introduces a simple and a fully-automated technique for producing bio-nanofertilizers from abundant green materials. These nano-fertilizers were produced using plant extracts as a protocol for the biosynthesis of nanoparticles based-fertilizers. The innovative device can work automatically without human intervention by programming its units to produce homogeneous nanoparticles. Three plant extracts (i.e., Nerium oleander, Azadirachta indica, and Cinnamomum camphora) were selected to produce nano selenium using this device, and the nano-products were further investigated using both zeta potential and transmission electron microscope (TEM). Further investigations including more nano-fertilizers will be published in the future with more details for different kinds of nutrients.

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Section: Resultsmentioning

confidence: 99%

Bio-Nano Fertilizers Preparation Using a Fully-Automated Apparatus: A Case Study of Nano-Selenium

El-Ghamry

El-Khateeb

Mosa

et al. 2021

EBSS

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“…What was found was the strength of nanoparticles, especially metal nanoparticles, in inhibiting the coronavirus. However, what is worrying is the inhalation of metal nanoparticles, especially copper oxide, which may cause adverse toxic reactions [ 8 , 17 , 26 , 79 ]. Therefore, metal nanoparticles in integration with PPE should be highly considered and analyzed.…”

Section: Preventionmentioning

confidence: 99%

“…Vaccines are currently based on killed viruses, whole-cell live attenuated vaccines, gene-based vaccines, and subunit vaccines [ 101 ]. Challenges that must be considered in the development of vaccines include efficacy, immunogenicity, vaccine safety, and risk of infection [ 17 ]. Previous knowledge of immune responses and the similarity of SARS-CoV-2 to other viruses, including SARS-CoV and MERS-CoV, has greatly contributed to the development of COVID-19 vaccines.…”

Section: Preventionmentioning

confidence: 99%

“…One of the major problems with many conventional vaccines which may reduce patient acceptance is the need for booster doses. Therefore, needle-free nanopatches have been proposed as a suitable method to accelerate vaccine delivery and reduce the burden on healthcare systems [ 17 ]. In single-dose vaccines that require slow release, the use of nano-based implants, intranasal-based nano-vaccines, and thin-film-based nano-vaccines may be appropriate options [ 174 , 175 ].…”

Section: Preventionmentioning

confidence: 99%

“…COVID-19 infections can also affect various organs in the body, including the central nervous system [ 10 , 11 ], cardiovascular system [ 12 ], kidneys [ 13 ], gastrointestinal tract [ 14 ], and liver [ 15 , 16 ]. Furthermore, a common cause of death is an uncontrolled cytokine, which can lead to stroke due to blood clots, organ failure, and heart attacks [ 17 ]. Due to SARS-CoV-2 must bind to angiotensin-converting enzyme 2 (ACE2) to enter host cells in humans, the expression and body localization of ACE2 is important [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

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Anti-COVID-19 Nanomaterials: Directions to Improve Prevention, Diagnosis, and Treatment

et al. 2022

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Following the announcement of the outbreak of COVID-19 by the World Health Organization, unprecedented efforts were made by researchers around the world to combat the disease. So far, various methods have been developed to combat this “virus” nano enemy, in close collaboration with the clinical and scientific communities. Nanotechnology based on modifiable engineering materials and useful physicochemical properties has demonstrated several methods in the fight against SARS-CoV-2. Here, based on what has been clarified so far from the life cycle of SARS-CoV-2, through an interdisciplinary perspective based on computational science, engineering, pharmacology, medicine, biology, and virology, the role of nano-tools in the trio of prevention, diagnosis, and treatment is highlighted. The special properties of different nanomaterials have led to their widespread use in the development of personal protective equipment, anti-viral nano-coats, and disinfectants in the fight against SARS-CoV-2 out-body. The development of nano-based vaccines acts as a strong shield in-body. In addition, fast detection with high efficiency of SARS-CoV-2 by nanomaterial-based point-of-care devices is another nanotechnology capability. Finally, nanotechnology can play an effective role as an agents carrier, such as agents for blocking angiotensin-converting enzyme 2 (ACE2) receptors, gene editing agents, and therapeutic agents. As a general conclusion, it can be said that nanoparticles can be widely used in disinfection applications outside in vivo. However, in in vivo applications, although it has provided promising results, it still needs to be evaluated for possible unintended immunotoxicity. Reviews like these can be important documents for future unwanted pandemics.

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Nanotechnological Strategy for the Diagnosis of Infectious Diseases

Thirumalaiswamy,

Vaishali,

Sundararaju

et al. 2024

Nanoscience and Nanotechnology for Smart Prevention, Diagnostics and Therapeutics

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Nanotechnology against COVID-19: Immunization, diagnostic and therapeutic studies

Cited by 40 publications

References 255 publications

Bio-Nano Fertilizers Preparation Using a Fully-Automated Apparatus: A Case Study of Nano-Selenium

Bio-Nano Fertilizers Preparation Using a Fully-Automated Apparatus: A Case Study of Nano-Selenium

Anti-COVID-19 Nanomaterials: Directions to Improve Prevention, Diagnosis, and Treatment

Nanotechnological Strategy for the Diagnosis of Infectious Diseases

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