Nanotechnology-aided diagnosis, treatment and prevention of leishmaniasis

Kammona, Olga; Tsanaktsidou, Evgenia

doi:10.1016/j.ijpharm.2021.120761

Cited by 19 publications

(24 citation statements)

References 302 publications

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“…Promising results have been obtained both at the in vitro and in vivo levels covering the treatment of different forms of the disease. Furthermore, some of these nanocarriers have already been or are currently undergoing in phase 1, 2, or 3 clinical trials of drug development studies. − …”

Section: Leishmaniasis Therapymentioning

confidence: 99%

A Systematic Review of Drug-Carrying Nanosystems Used in the Treatment of Leishmaniasis

et al. 2023

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Leishmaniasis is an infectious disease responsible for a huge rate of morbidity and mortality in humans. Chemotherapy consists of the use of pentavalent antimonial, amphotericin B, pentamidine, miltefosine, and paromomycin. However, these drugs are associated with some drawbacks such as high toxicity, administration by parenteral route, and most seriously the resistance of some strains of the parasite to them. Several strategies have been used to increase the therapeutic index and reduce the toxic effects of these drugs. Among them, the use of nanosystems that have great potential as a site-specific drug delivery system stands out. This review aims to compile results from studies that were carried out using first-and second-line antileishmanial drugcarrying nanosystems. The articles referred to here were published between 2011 and 2021. This study shows the promise of effective applicability of drug-carrying nanosystems in the field of antileishmanial therapeutics, with the perspective of providing better patient adherence to treatment, increased therapeutic efficacy, reduced toxicity of conventional drugs, as well as the potential to efficiently improve the treatment of leishmaniasis.

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Section: Leishmaniasis Therapymentioning

confidence: 99%

A Systematic Review of Drug-Carrying Nanosystems Used in the Treatment of Leishmaniasis

et al. 2023

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“…They have been proposed for applications ranging from electronic and biomedical devices to environment and energy technologies [ 1 , 2 , 3 , 4 , 5 ]. Moreover, the intrinsic biological properties of silver and gold nanoparticles (Ag NPs and Au NPs) as antimicrobial, anticancer, and anti-leishmanial agents have been investigated [ 6 , 7 , 8 , 9 ]. As compared to the monometallic nanoparticles (MNPs), the bimetallic nanoparticles (BMNPs) constitute a new class of nanostructures that generally displays superior technological relevance.…”

Section: Introductionmentioning

confidence: 99%

State of the Art on Green Route Synthesis of Gold/Silver Bimetallic Nanoparticles

et al. 2022

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Recently, bimetallic nanoparticles (BMNPs) blending the properties of two metals in one nanostructured system have generated enormous interest due to their potential applications in various fields including biosensing, imaging, nanomedicine, and catalysis. BMNPs have been developed later with respect to the monometallic nanoparticles (MNPs) and their physicochemical and biological properties have not yet been comprehensively explored. The manuscript aims at collecting the main design criteria used to synthetize BMNPs focusing on green route synthesis. The influence of experimental parameters such as temperature, time, reagent concentrations, capping agents on the particle growth and colloidal stability are examined. Finally, an overview of their nanotechnological applications and biological profile are presented.

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“…According to the current WHO data, 50.000–90.000 new cases of visceral leishmaniasis [ 17 ] (the most severe form of this disease associated with high mortality rate if not promptly diagnosed and treated) are estimated to annually occur worldwide, predominantly in least developing countries due to poor hygiene, lack of protective measures (vector control), and lack of appropriate health infrastructures [ 18 – 19 ]. In addition, antileishmanial drugs which are currently available on the market showed several drawbacks including irreversible toxic effects, high costs, prolonged treatment, need for adequate medical care, emergence of drug resistance, and parenteral administration [ 20 – 21 ]. Recently, nanoantimicrobials based on biogenic noble metal NPs produced by reduction of gold or silver ions with natural extracts have been proposed for the treatment of leishmaniasis, acting against both promastigote and amastigote forms of L. donovani [ 22 – 23 ].…”

Section: Introductionmentioning

confidence: 99%

Supramolecular assembly of pentamidine and polymeric cyclodextrin bimetallic core–shell nanoarchitectures

Hada¹,

Burduja²,

Abbate³

et al. 2022

Beilstein J. Nanotechnol.

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Advanced nanoscale antimicrobials, originated from the combination of noble metal nanoparticles (NPs) with conventional antimicrobial drugs, are considered the next generation of antimicrobial agents. Therefore, there is an increasing demand for rapid, eco-friendly, and relatively inexpensive synthetic approaches for the preparation of nontoxic metallic nanostructures endowed with unique physicochemical properties. Recently, we have proposed a straightforward synthetic strategy that exploits the properties of polymeric β-cyclodextrin (PolyCD) to act as both the reducing and stabilizing agent to produce monodispersed and stable gold-based NPs either as monometallic (nanoG) structures or core–shell bimetallic (nanoGS) architectures with an external silver layer. Here, we describe the preparation of a supramolecular assembly between nanoGS and pentamidine, an antileishmanial drug endowed with a wide range of therapeutic properties (i.e., antimicrobial, anti-inflammatory, and anticancer). The physicochemical characterization of the supramolecular assembly (nanoGSP) in terms of size and colloidal stability was investigated by complementary spectroscopic techniques, such as UV–vis, ζ-potential, and dynamic light scattering (DLS). Furthermore, the role of PolyCD during the reduction/stabilization of metal NPs was investigated for the first time by NMR spectroscopy.

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Nanotechnology-aided diagnosis, treatment and prevention of leishmaniasis

Cited by 19 publications

References 302 publications

A Systematic Review of Drug-Carrying Nanosystems Used in the Treatment of Leishmaniasis

A Systematic Review of Drug-Carrying Nanosystems Used in the Treatment of Leishmaniasis

State of the Art on Green Route Synthesis of Gold/Silver Bimetallic Nanoparticles

Supramolecular assembly of pentamidine and polymeric cyclodextrin bimetallic core–shell nanoarchitectures

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