Nanotechnology and Drug Delivery

Yu, Xiaojun; Valmikinathan, Chandra M.; Rogers, Amanda; Wang, Junping

doi:10.1002/9780470185834.ch5

Cited by 5 publications

(1 citation statement)

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“…It is noteworthy to mention that the largest size of rigid particles to safely circulate within the capillaries is around 5 μm, whereas the largest particle to be up taken by cell can be up to 500 nm . In the case of cancer drug delivery, even large nanocarriers with sizes of ∼400 nm are demonstrated to take advantage of enhanced permeation and retention effect (EPR effect) for passive tumor targeting. − The developed Sblg-f-MWCNTs exhibit average particle size of ∼315 nm.…”

Section: Discussionmentioning

confidence: 99%

Succinylated β-Lactoglobuline-Functionalized Multiwalled Carbon Nanotubes with Improved Colloidal Stability and Biocompatibility

Jain

Dongave

Date

et al. 2019

ACS Biomater. Sci. Eng.

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PEGylation (i.e., attachment of polyethylene-glycol) of carbon nanotubes (CNTs) is one of the most widely used strategies to improve its biocompatibility and aqueous dispersion stability, which are critical for their successful clinical application. However, PEGylation of nanomaterials has recently been associated with production of anti-PEG antibody, low cellular uptake, and degradation. Herein, we explore surface functionalization of CNTs using the bovine-milk-derived protein succinylated β-lactoglobuline (Sblg) as an alternative strategy to PEGylation. The aqueous dispersion stability, in vitro cell uptake and biocompatibility of Sblg-functionalized multiwalled CNTs (Sblg-f-MWCNTs) was compared to PEGylated MWCNTs (PEG-f-MWCNTs). The surface functionalization with Sblg was found to improve the IC50 values of CNTs by ∼5- to 6-fold in comparison with pristine CNTs in various cell lines. Both Sblg-f-MWCNTs and PEG-f-MWCNTs improved the aqueous colloidal stability of CNTs, which remained suspended for a period of one month. Our study concluded that the Sblg provides a cost-effective alternative to the PEG-based CNT functionalization with significant improvement in the biocompatibility and dispersion stability of CNTs.

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Section: Discussionmentioning

confidence: 99%

Succinylated β-Lactoglobuline-Functionalized Multiwalled Carbon Nanotubes with Improved Colloidal Stability and Biocompatibility

Jain

Dongave

Date

et al. 2019

ACS Biomater. Sci. Eng.

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Nanocrystals Production, Characterization, and Application for Cancer Therapy

Hollis

2013

Pharmaceutical Sciences Encyclopedia

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The delivery of synthesized drugs exhibiting poor solubility in water is extremely difficult, limiting bioavailability and causing adverse effects when solubilized. A need was determined for developing a formulation to deliver poorly water‐soluble drugs without indiscriminately reaching healthy organs and tissues. Therefore, nanocrystal formulations have been a significant focus for delivering poorly water‐soluble drugs via oral, paraenteral, and alternative routes. Using nanocrystal formulations avoids potential side effects and instability related to many existing delivery systems. Currently, few cancer therapy products are approved by the Food and Drug Administration (FDA) in which poorly soluble drugs are formulated by nanoparticles. In this chapter, the production of nanocrystals of pharmaceutical organic compounds is reviewed. Thereafter, the chapter will focus on the application of nanocrystals for cancer therapy.

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