The expression and discussion of ideas regarding common concerns and collective social interests create and happen in public spheres. This chapter reflects on the relationship between public spheres and technology assessment (TA) in the context of globalization. In doing so, we follow the all-affected principle, which implies that TA should take into account all kinds of people that are affected worldwide by science, technology, and innovation (STI). This chapter first examines the relationship between TA and public spheres that deal with the societal significance of STI from a national context, because both are mainly approached from the point of view of national political decision-making. We then reflect on public spheres in a context of globalization and describe how TA institutes, networks, and activities are organized beyond national borders. Next the link between public spheres and TA in a global context is studied. Finally, a blueprint for the future of global TA is sketched.