Nanotechnology and Microfluidics for Biosensing and Biophysical Property Assessment

Li, Zida; Shum, Ho Cheung

doi:10.1002/9783527818341.ch3

Cited by 8 publications

(4 citation statements)

References 107 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Microfluidic systems have been integrated with bead-based biosensors to enhance the assay performance and enable precise manipulation of samples and reagents [57]. Microfluidic platforms offer advantages such as reduced sample volumes, enhanced mixing, rapid reaction kinetics, and improved sensitivity.…”

Section: Integration With Microfluidics and Nanotechnologymentioning

confidence: 99%

Recent Trends and Innovations in Bead-Based Biosensors for Cancer Detection

Cheng,

Yang,

Wang

et al. 2024

Sensors

View full text Add to dashboard Cite

Demand is strong for sensitive, reliable, and cost-effective diagnostic tools for cancer detection. Accordingly, bead-based biosensors have emerged in recent years as promising diagnostic platforms based on wide-ranging cancer biomarkers owing to the versatility, high sensitivity, and flexibility to perform the multiplexing of beads. This comprehensive review highlights recent trends and innovations in the development of bead-based biosensors for cancer-biomarker detection. We introduce various types of bead-based biosensors such as optical, electrochemical, and magnetic biosensors, along with their respective advantages and limitations. Moreover, the review summarizes the latest advancements, including fabrication techniques, signal-amplification strategies, and integration with microfluidics and nanotechnology. Additionally, the challenges and future perspectives in the field of bead-based biosensors for cancer-biomarker detection are discussed. Understanding these innovations in bead-based biosensors can greatly contribute to improvements in cancer diagnostics, thereby facilitating early detection and personalized treatments.

show abstract

Section: Integration With Microfluidics and Nanotechnologymentioning

confidence: 99%

Recent Trends and Innovations in Bead-Based Biosensors for Cancer Detection

Cheng,

Yang,

Wang

et al. 2024

Sensors

View full text Add to dashboard Cite

show abstract

“…The first important issue in terms of scientific, technological, and/or analytical matters is the methodology leading to the effective fabrication of targeted devices. The current state of the art studies have focused on laminates, molding-based, 3D printing, and micro/nano fabrication methods with distinct benefits and limitations [430][431][432]. Nevertheless, the primary goal of microfluidic single RBC research remains in finding the most convenient ways to advance biological and analytical studies in application-specific systems, such as chemotaxic assays, low resource diagnosis, and rapid assessment of biofluids [433].…”

Section: Future Considerationsmentioning

confidence: 99%

Advances in Microfluidics for Single Red Blood Cell Analysis

et al. 2023

View full text Add to dashboard Cite

The utilizations of microfluidic chips for single RBC (red blood cell) studies have attracted great interests in recent years to filter, trap, analyze, and release single erythrocytes for various applications. Researchers in this field have highlighted the vast potential in developing micro devices for industrial and academia usages, including lab-on-a-chip and organ-on-a-chip systems. This article critically reviews the current state-of-the-art and recent advances of microfluidics for single RBC analyses, including integrated sensors and microfluidic platforms for microscopic/tomographic/spectroscopic single RBC analyses, trapping arrays (including bifurcating channels), dielectrophoretic and agglutination/aggregation studies, as well as clinical implications covering cancer, sepsis, prenatal, and Sickle Cell diseases. Microfluidics based RBC microarrays, sorting/counting and trapping techniques (including acoustic, dielectrophoretic, hydrodynamic, magnetic, and optical techniques) are also reviewed. Lastly, organs on chips, multi-organ chips, and drug discovery involving single RBC are described. The limitations and drawbacks of each technology are addressed and future prospects are discussed.

show abstract

“…Currently, many in vitro diagnostic tests are done with benchtops laboratories. Therefore, nanotechnology will be combined with microfluidics to develop the next-generation in vitro diagnostic tests, allowing sample preparation and handling with minimal human interference, improving sensitivity and efficiency (123).…”

Section: Prospects and Challengesmentioning

confidence: 99%

The impact of nanotechnology in health: A review of recent studies and products.

Menezes de Souza,

Silva,

Fabrino

et al. 2023

Rev. Cont. Saúde

View full text Add to dashboard Cite

Several people suffer from diseases and injuries and many of them die because of late diagnostic and/or inefficient treatment. Many of these diseases affect humans and animals, and animals can be vectors for humans. In this perspective, it is necessary works that integrate humans, animals, and ecosystems, thus, to arise the One Health. Along with it, nanotechnology is a great alternative to improve health care, due to its revolutionary and complex properties. Although, how can nanomaterials be capable of work with or against cells, tissues, drugs, and medical devices? There are already many products in the market, but there are a lot of challenges to face and a whole new world to discover. In this article are given the application of nanostructures in diagnostic, therapy, medical devices, tissue and implant engineering, human health and animal, and a future perspective.

show abstract

Nanotechnology and Microfluidics for Biosensing and Biophysical Property Assessment

Cited by 8 publications

References 107 publications

Recent Trends and Innovations in Bead-Based Biosensors for Cancer Detection

Recent Trends and Innovations in Bead-Based Biosensors for Cancer Detection

Advances in Microfluidics for Single Red Blood Cell Analysis

The impact of nanotechnology in health: A review of recent studies and products.

Contact Info

Product

Resources

About