Nanotechnology-Applied Curcumin for Different Diseases Therapy

Ghalandarlaki, Negar; Alizadeh, Ali Mohammad; Ashkani-Esfahani, Soheil

doi:10.1155/2014/394264

Cited by 235 publications

(144 citation statements)

References 133 publications

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“…Any compound, irrespective of its solubility, can be entrapped inside a liposome, resulting in a slow degradation during transport to the target, minimal side-effects and greater stability (Ghalandarlaki et al 2014).…”

Section: Liposomal Systems As Carriers For Bioactive Compoundsmentioning

confidence: 99%

Liposomal systems as carriers for bioactive compounds

et al. 2015

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Since the revolutionary discovery that phospholipids can form closed bilayered structures in aqueous systems, the study of liposomes has become a very interesting area of research. The versatility and amazing biocompatibility of liposomes has resulted in their wide-spread use in many scientific fields, and many of their applications, especially in medicine, have yielded breakthroughs in recent decades. Specifically, their easy preparation and various structural aspects have given rise to broadly usable methodologies to internalize different compounds, with either lipophilic or hydrophilic properties. The study of compounds with potential biotechnological application(s) is generally related to evaluation and risk assessment of the possible cytotoxic or therapeutic effects of the compound under study. In most cases, undesirable sideeffects are associated with an interaction of the liposome with the cell membrane and/or its absorption and subsequent interaction with a cellular biomolecule. Liposomal carrier systems have an unprecedented potential for delivering bioactive substances to specific molecular targets due to their biocompatibility, biodegradability and low toxicity. Liposomes are therefore considered to be an invaluable asset in applied biotechnology studies due to their potential for interaction with both hydrophilic and lipophilic compounds.

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Section: Liposomal Systems As Carriers For Bioactive Compoundsmentioning

confidence: 99%

Liposomal systems as carriers for bioactive compounds

et al. 2015

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“…However, a poor solubility of curcumin in water at physiological pH and low bioavailability limited the absorption of curcumin after administration (Jäger et al, 2014;Siviero et al, 2015). To overcome the problems of poor solubility and low bioavailability, recently several nanotechnology approaches have been reported for the encapsulation of curcumin into nanoparticles such as liposomes, polymeric nanoparticles, micelles, nanogels, cyclodextrins, dendrimers, silvers and solid lipids as one of the useful alternatives (Ghalandarlaki et al, 2014). Although these biocompatible nanocarriers hold a promise to enhance the bioavailability and deliver therapeutic concentrations of curcumin the safety and toxicity issues cannot be ignored.…”

Section: Introductionmentioning

confidence: 99%

Curcumin nanosuspension: Screening for antioxidant and antibacterial activities and study of protein adsorption

Wanitchayadamkerng¹,

Thao²,

Watcharin³

2017

j.appsci

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Curcumin is considered to be a powerful bioactive agent, which is extensively known for its medicinal use. Despite its being excellent therapeutic agent and natural antioxidant, curcumin shows poor solubility and bioavailability. Therefore, the development of formulation of curcumin nanoparticles to improve its aqueous-phase solubility and absorption is beneficial. In the present study, we investigated the formulation of a curcumin nanosuspension (CN) at curcumin concentration of 0.025-0.100 mg/mL with/without surfactant by sonication method and examined its antioxidant activity. Surface modification of CN was carried out by coating with 1% sodium docecyl sulfate (SDS) as surfactant to obtain the modified CN with SDS (CNS). The particle size and morphology of CN and CNS were studied by scanning electron microscopy (SEM). An antioxidant activity was measured using a 2,2-Diphenyl-1-picrylhydrazyl (DPPH) assay. The CN without SDS at curcumin concentration of 0.025 mg/ml exhibited the highest antioxidant activity compared with other formulations. An antimicrobial effect of CN with/without SDS was tested by agar-well diffusion method. It was found that the highst antimicrobial activity against Bacillus Cereus was observed for the CNS at the curcumin concentration of 0.050 mg/mL with an inhibition zone of 15.7 ± 1.5 mm. Protein adsorption was investigated using model protein bovine serum albumin (BSA). At curcumin concentration of 0.100 mg/mL, BSA adsorption of CNS was approximately 2 times greater than the unmodified at the same conditions after 24 h which suggests that this formulation of CN increases its bioavailability and may serve as potential bioactive agent for combination therapy.

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“…Curcumin, a plant polyphenol extracted from the turmeric rhizome, possesses antioxidant, anticoagulant, anti-inflammatory, anti-atherosclerotic, lipid-lowering and anti-aging properties (9,10). Previous studies have demonstrated that curcumin is a highly effective anticancer agent (10,11).…”

Section: Introductionmentioning

confidence: 99%

Curcumin mediates reversion of HGF-induced epithelial-mesenchymal transition via inhibition of c-Met expression in DU145 cells

Lin

Liu

et al. 2015

Oncology Letters

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Abstract. The hepatocyte growth factor (HGF)/c-Met signaling pathway results in cancer cell scattering and invasion, and has been reported to participate in several types of cancer, including prostate and colorectal cancer. The downstream phosphorylation cascade of HGF, particularly the mitogen-activated protein kinase and phosphoinositide 3-kinase/AKT signaling pathway, regulates epithelial-mesenchymal transition (EMT). However, the mechanism by which these signaling pathways govern EMT, and whether certain kinases are able to respond to specific EMT effectors, remains to be elucidated. In the present study, an increase in the levels of vimentin, rather than co-regulation of certain EMT marker proteins, was observed in response to HGF-induced EMT in DU145 prostate cancer cells. In addition, it was observed that curcumin abrogated HGF-induced DU145 cell scattering and invasion. Furthermore, curcumin was able to effectively inhibit the HGF-induced increase in the levels of vimentin by downregulating the expression of phosphorylated c-Met, extracellular signal-regulated kinase and Snail. In conclusion, the results of the present study demonstrated that curcumin was able to reverse HGF-induced EMT, possibly by inhibiting c-Met expression in DU145 prostate cancer cells.

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Nanotechnology-Applied Curcumin for Different Diseases Therapy

Cited by 235 publications

References 133 publications

Liposomal systems as carriers for bioactive compounds

Liposomal systems as carriers for bioactive compounds

Curcumin nanosuspension: Screening for antioxidant and antibacterial activities and study of protein adsorption

Curcumin mediates reversion of HGF-induced epithelial-mesenchymal transition via inhibition of c-Met expression in DU145 cells

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