Nanotechnology Based Drug Delivery for HIV-AIDS Treatment

Abstract

One of the biggest challenges of the world in this 21st century is to cure HIV-AIDS. In Present scenario different antiviral drugs are available in the market to reduce the worse condition and manage improved survival rate. These drugs are manageable but their bioavailability, lower permeability and poor half life of the drugs have limitations. If the drug is preferred in higher dosage in AIDS patients, the drug leads to toxicity and adverse effects to patients and increase resistant against HIV & if the drug is preferred in lower dose along with nano carriers it will reach the target area for beneficial effect, therefore drugs Lacking of Knowledge in Potent Drug delivery systems is due to instability, chemical degradation and tissue barrier difficulties are reasons to reach drug target successfully. In this scenario Nanotechnology based antiretroviral drugs delivery holds drug and will provide to cure AIDS. Nanotechnology based deliver system Nanocarriers like Liposomes, dendrimers, Nanoparticles, Polymeric Micelles, Nanovesicles, Nanoemulsion provide the way to deliver drug to targeting tissue. Nanobased carriers revolutionized the field of Pharmaceutics and Pharmaco Kinetic’s in target drug delivery. The present study depicts nano based ARV drug provides increase efficiency with less adverse effects to control HIV. Like same way we can provide and increase nanobased drug delivery capacity to other available HIV drugs.

Recent advancement in nanomaterial-encapsulated drug delivery vehicles for combating cancer, COVID-19, and HIV-like chronic diseases

“…Liposomes, upon getting into a living organism, embeds itself within the mononuclear phagocytic cells (macrophages), such that the liposomes become useful anti-HIV drug transporter toward the targeted cell. 224 Consequently, liposomes improve the efficacy of the anti-HIV medicine by reducing its side effects. Literature reports that around 20 years ago, the primary attempts made for delivering HIV antigens involved in the utilization of liposomes.…”

Synthesis and characterization of tenofovir disoproxil fumarate loaded nanoparticles for HIV‐1 treatment

“…The field of nanomedicine has presented promising strategies to address challenges associated with ARV's by modifying drug molecules into nanoscale dimensions. [ 3,7 ] Extensive research has been conducted on nanomedicine‐based systems, for controlled drug release, drug targeting, and diagnostic imaging. [ 8,9 ] These nanosystems aim to deliver drugs to target cells in a precise manner, enhancing the specificity of drug‐receptor interactions, eliminating off‐target effects, prolonging drug half‐life, and improving drug efficacy.…”