Nanotechnology-Based Mucoadhesive and Mucus-Penetrating Drug-Delivery Systems for Transbuccal Drug Delivery

Desai, Digvijay Dattatray; Manikkath, Jyothsna; Lad, Hitesh; Kulkarni, Mugdha; Manikkath, Aparna; Radhakrishnan, Raghu

doi:10.2217/nnm-2023-0180

Cited by 6 publications

(2 citation statements)

References 106 publications

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“…Topical delivery is more suitable for the treatment of various oral mucosal pathologies caused by inflammatory, autoimmune and infectious factors. In turn, dosage forms for transmucosal delivery should provide high oral bioavailability (adequate rate of absorption of drugs into the bloodstream at a given therapeutic level) [172,173]. The buccal mucosa is poorly permeable to drugs and does not provide high bioavailability compared to sublingual administration, but the sublingual mucosa is irregular and mobile and constantly washed with saliva, making controlled transmucosal drug delivery problematic (except for fast-acting formulations, e.g., angina sprays, etc.).…”

Section: Dosage Forms For Oromucosal Applicationmentioning

confidence: 99%

Biopolymer Drug Delivery Systems for Oromucosal Application: Recent Trends in Pharmaceutical R&D

Dubashynskaya,

Petrova,

Skorik

2024

IJMS

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Oromucosal drug delivery, both local and transmucosal (buccal), is an effective alternative to traditional oral and parenteral dosage forms because it increases drug bioavailability and reduces systemic drug toxicity. The oral mucosa has a good blood supply, which ensures that drug molecules enter the systemic circulation directly, avoiding drug metabolism during the first passage through the liver. At the same time, the mucosa has a number of barriers, including mucus, epithelium, enzymes, and immunocompetent cells, that are designed to prevent the entry of foreign substances into the body, which also complicates the absorption of drugs. The development of oromucosal drug delivery systems based on mucoadhesive biopolymers and their derivatives (especially thiolated and catecholated derivatives) is a promising strategy for the pharmaceutical development of safe and effective dosage forms. Solid, semi-solid and liquid pharmaceutical formulations based on biopolymers have several advantageous properties, such as prolonged residence time on the mucosa due to high mucoadhesion, unidirectional and modified drug release capabilities, and enhanced drug permeability. Biopolymers are non-toxic, biocompatible, biodegradable and may possess intrinsic bioactivity. A rational approach to the design of oromucosal delivery systems requires an understanding of both the anatomy/physiology of the oral mucosa and the physicochemical and biopharmaceutical properties of the drug molecule/biopolymer, as presented in this review. This review summarizes the advances in the pharmaceutical development of mucoadhesive oromucosal dosage forms (e.g., patches, buccal tablets, and hydrogel systems), including nanotechnology-based biopolymer nanoparticle delivery systems (e.g., solid lipid particles, liposomes, biopolymer polyelectrolyte particles, hybrid nanoparticles, etc.).

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Section: Dosage Forms For Oromucosal Applicationmentioning

confidence: 99%

Biopolymer Drug Delivery Systems for Oromucosal Application: Recent Trends in Pharmaceutical R&D

Dubashynskaya,

Petrova,

Skorik

2024

IJMS

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“…However, some disadvantages can be mentioned: the interference of saliva, which can dilute the drug absorption; the environment of the oral cavity due to food consumption; and the permeability, which can be too low for certain drugs [12]. Recent advances in chemical, material, and engineering techniques bring great opportunities to improve intraoral system fabrication and applications owing to the high biocompatibility and functional diversity [13][14][15].…”

Section: Introductionmentioning

confidence: 99%

A Synthetic Model of the Mucosa for Oral Penetration Studies

Alonso,

Martí,

Ramos

et al. 2023

Membranes

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The main objective of this study is the evaluation of the use of a synthetic membrane, Nuclepore, as a model for permeation studies through sublingual mucosa. The permeability of two types of membranes, porcine sublingual oral mucosa and a synthetic Nuclepore membrane, to water was compared. Moreover, the water permeability of membranes modified with waterproofing formulations was measured to study their ability to protect against the penetration of viruses, toxins, etc. A relatively high correlation (R2 0.88) was obtained between the transmucosal water loss (TMWL) values of the artificial membrane and the mucosa. These results support the possible use of this synthetic membrane in the screening of the water permeability of formulations. In addition, studies of the permeation of different actives, drugs, and biocides through the two membranes were carried out, and these results were compared with their skin permeation data. The synthetic membrane does not seem to discern between compounds in terms of permeability. However, the permeation of caffeine through intact or modified membranes incorporating waterproofing formulations presents similar permeation profiles through the synthetic membrane and mucosa. The results from these assays should lend support to the use of this synthetic membrane when screening formulations to be applied in oral penetration studies.

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