Nanotechnology-Based Self-Sterilizing Surfaces and Their Potential in Combating COVID-19

Prasher, Parteek; Sharma, Mousmee

doi:10.2217/nnm-2021-0079

Cited by 21 publications

(14 citation statements)

References 20 publications

(16 reference statements)

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“…Recently, Balagna et al [5] showed that silver nanocluster/silica composite sputtered coating over commercial facemask has excellent virucidal activity against SARS-CoV-2. Another milestone in this area is the generation of a photo sterile mask by the utilization of photo-thermal effects of nanomaterials [48] . The self-sterile properties along with super hydrophobic nature of these surfaces make the mask more effective to stop the spreading of COVID-19 [49] .…”

Section: The Nanocoatings: the Future Of Antiviral Surfacesmentioning

confidence: 99%

Nanocoatings: Universal antiviral surface solution against COVID-19

Chithra

Abraham

et al. 2022

Progress in Organic Coatings

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In the current scenario, there is critical global demand for the protection of daily handling surfaces from the viral contamination to limit the spread of COVID-19 infection. The nanotechnologists and material scientists offer sustainable solutions to develop antiviral surface coatings for various substrates including fabrics, plastics, metal, wood, food stuffs etc. to face current pandemic period. They create or propose antiviral surfaces by coating them with nanomaterials which interact with the spike protein of SARS-CoV-2 to inhibit the viral entry to the host cell. Such nanomaterials involve metal/metal oxide nanoparticles, hierarchical metal/metal oxide nanostructures, electrospun polymer nanofibers, graphene nanosheets, chitosan nanoparticles, curcumin nanoparticles, etched nanostructures etc. The antiviral mechanism involves the repletion (depletion) of the spike glycoprotein that anchors to surfaces by the nanocoating and makes the spike glycoprotein and viral nucleotides inactive. The nature of interaction between the nanomaterial and virus depends on the type nanostructure coating over the surface. It was found that functional coating materials can be developed using nanomaterials as their polymer nanocomposites. The various aspects of antiviral nanocoatings including the mechanism of interaction with the Corona Virus, the different type of nanocoatings developed for various substrates, future research areas, new opportunities and challenges are reviewed in this article.

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Section: The Nanocoatings: the Future Of Antiviral Surfacesmentioning

confidence: 99%

Nanocoatings: Universal antiviral surface solution against COVID-19

Chithra

Abraham

et al. 2022

Progress in Organic Coatings

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“… 73 Metallic NPs can have intrinsic photocatalytic and photodynamic functionalities to inhibit viral protein. 72 , 74 …”

Section: Combat Of Sars-cov-2mentioning

confidence: 99%

“…73 Metallic NPs can have intrinsic photocatalytic and photodynamic functionalities to inhibit viral protein. 72,74 ZnO nanospray as a potential disinfectant has shown to be promising in deactivating SARS-CoV-2. 75,76 ZnO-induced ROS generations make up one of the potential pathways for cellular death.…”

Section: Combat Of Sars-cov-2mentioning

confidence: 99%

“…After the Covid-19 outbreaks, many attempts have been taken to eliminate the existing drawbacks of disinfectant and protective masks. , Nanotechnology also plays an important role in the development of potentially cost-effective, reusable, user-friendly, and more effective disinfectants and surface modifications for the protective mask (Figure ). Metallic NPs (silver, copper, titanium dioxide nanoparticles) have broad-spectrum antiviral potentials that can be utilized as a coating for public surface and protective mask coatings . Metallic NPs can have intrinsic photocatalytic and photodynamic functionalities to inhibit viral protein. , …”

Section: Combat Of Sars-cov-2mentioning

confidence: 99%

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Advances in Nanomaterial-Based Platforms to Combat COVID-19: Diagnostics, Preventions, Therapeutics, and Vaccine Developments

Mahmud¹,

Anik

Hossain

et al. 2022

ACS Appl. Bio Mater.

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The COVID-19 pandemic caused by the SARS-CoV-2, a ribonucleic acid (RNA) virus that emerged less than two years ago but has caused nearly 6.1 million deaths to date. Recently developed variants of the SARS-CoV-2 virus have been shown to be more potent and expanded at a faster rate. Until now, there is no specific and effective treatment for SARS-CoV-2 in terms of reliable and sustainable recovery. Precaution, prevention, and vaccinations are the only ways to keep the pandemic situation under control. Medical and scientific professionals are now focusing on the repurposing of previous technology and trying to develop more fruitful methodologies to detect the presence of viruses, treat the patients, precautionary items, and vaccine developments. Nanomedicine or nanobased platforms can play a crucial role in these fronts. Researchers are working on many effective approaches by nanosized particles to combat SARS-CoV-2. The role of a nanobased platform to combat SARS-CoV-2 is extremely diverse (i.e., mark to personal protective suit, rapid diagnostic tool to targeted treatment, and vaccine developments). Although there are many theoretical possibilities of a nanobased platform to combat SARS-CoV-2, until now there is an inadequate number of research targeting SARS-CoV-2 to explore such scenarios. This unique mini-review aims to compile and elaborate on the recent advances of nanobased approaches from prevention, diagnostics, treatment to vaccine developments against SARS-CoV-2, and associated challenges.

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“…Amongst these polymers, poly (methyl methacrylate), or shortly PMMA, has a significant role in the polymer industry [1][2][3][4][5]. This has become further evident during the current COVID pandemic through the utilization of PMMA for personal protective equipment [6][7][8][9][10][11]. PMMA is a good glass substitute thanks to its mechanical properties and transparency [1,3,12,13].…”

Section: Introductionmentioning

confidence: 99%

Combining Chromatographic, Rheological, and Mechanical Analysis to Study the Manufacturing Potential of Acrylic Blends into Polyacrylic Casts

et al. 2021

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Polyacrylics have been considered for a broad range of material applications, including coatings, dental applications, and adhesives. In this experimental study, the casting potential of a group of (co)monomers belonging to the acrylic family has been explored to enable a more sustainable use of these polymer materials in the medical and veterinary science field. The individual contributions of each comonomer have been analyzed, the reaction conversion has been studied via gas chromatography (GC), the rheological behavior has been characterized via stress-controlled measurements, and the final mechanical properties have been obtained from tensile, flexure, and impact tests. The GC results allow assessing the pot life and thus the working window of the casting process. For the rheological measurements, which start from low-viscous mixtures, a novel protocol has been introduced to obtain accurate absolute data. The rheological data reflect the time dependencies of the GC data but facilitate a more direct link with the macroscopic material data. Specifically, the steep increase in the viscosity with increasing reaction time for the methyl methacrylate (MMA)/ethylene glycol dimethyl methacrylate (EGDMA) case (2% crosslinker) allows maximizing several mechanical properties: the tensile/flexure modulus, the tensile/flexure stress at break, and the impact strength. This opens the pathway to more dedicated chemistry design for corrosion casting and polyacrylic material design in general.

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Nanotechnology-Based Self-Sterilizing Surfaces and Their Potential in Combating COVID-19

Cited by 21 publications

References 20 publications

Nanocoatings: Universal antiviral surface solution against COVID-19

Nanocoatings: Universal antiviral surface solution against COVID-19

Advances in Nanomaterial-Based Platforms to Combat COVID-19: Diagnostics, Preventions, Therapeutics, and Vaccine Developments

Combining Chromatographic, Rheological, and Mechanical Analysis to Study the Manufacturing Potential of Acrylic Blends into Polyacrylic Casts

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