Nanotechnology-based strategies for gastric cancer imaging and treatment

Abstract

Nanoparticles designed for gastric cancer theronostics.

Tracers in Gastric Cancer Surgery

“…With the advance of nanomedicine, multiple nanoparticles have been utilized in gastric carcinoma diagnosis and treatment preclinically, which is another potential development direction [ 128 ]. Through exploitation of the particular combination properties of the Arg-Gly-Asp (RGD) sequence and of integrin overexpressed in gastric cancer cells, ICG has been transported to tumor locations for more specific imaging [ 129 , 130 ].…”

Current and future strategies for radiation therapy in gastric cancer

“…Going forward, advances in nanotechnology and molecular imaging may provide us with the tools capable of detecting occult nodal, peritoneal, and distant metastases, modify our treatment design and be paradigm changing. 59 Exploiting their nanoscale, nanoparticles can carry contrast agents and drug, as well radioisotopes to visualize tumors, as well as dynamic changes in its microenvironment (e. "library of plans" will contribute to the efficiency of this type of approach. 42,60 With improved accuracy of imaging and targeting, the ability to deliver higher (or lower) doses safely to selected regions and selected populations is expected to improve outcomes.…”

“…Going forward, advances in nanotechnology and molecular imaging may provide us with the tools capable of detecting occult nodal, peritoneal, and distant metastases, modify our treatment design and be paradigm changing 59 …”

Triphenylphosphonium conjugated gold nanotriangles impact Pi3K/AKT pathway in breast cancer cells: a photodynamic therapy approach

“…Hence, providing patients with effective drugs that minimize harmful effects is the need of the hour. To combat this issue, nanotechnology has emerged as a superior platform for the simultaneous delivery of drugs [6][7][8][9] .In this journey, therapeutic nanoparticles selectively target tumors, enhance anticancer effectiveness and circumventing drug resistance [10][11][12] . For instance, gold nanoparticles are among the most promising agents for cancer treatment due to these reasons; (i) small and capable of selectively penetrating cancer cells through the enhanced permeability and retention (EPR) effect 13,14 (ii) their ability to bind proteins and drugs in targeting cancer cells that possess cell surface receptors 15,16 (iii) can absorb light radiations and provide better contrast images than conventional agents 17,18 .Over the last few decades, gold nanoparticles have been conjugated with various functionalizing moieties, including ligands, therapeutic agents, DNA, amino acids, proteins, peptides, oligonucleotides, etc [19][20][21][22] .…”

“…Hence, providing patients with effective drugs that minimize harmful effects is the need of the hour. To combat this issue, nanotechnology has emerged as a superior platform for the simultaneous delivery of drugs [6][7][8][9] .…”