Nanotechnology-Based Strategies to Overcome Current Barriers in Gene Delivery

Mirón-Barroso, Sofía; Doménech, Elena; Trigueros, Sònia

doi:10.3390/ijms22168537

Cited by 49 publications

(31 citation statements)

References 134 publications

(141 reference statements)

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“…Gene therapy is an experimental technique that works by replacing and knocking out mutated genes, as well as introducing new genes into desired cells. 37–40 Researchers have proposed several gene delivery methods, but the main hurdle is finding vectors to protect genes from degradation, with good potential for low membrane permeability and low immunogenicity. 39–41 Gene therapy offers a great opportunity to fight cancer diseases.…”

Section: Classification Of Vectorsmentioning

confidence: 99%

Delivery process and effective design of vectors for cancer therapy

Gao

Cong

et al. 2022

J. Mater. Chem. B

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Section: Classification Of Vectorsmentioning

confidence: 99%

Delivery process and effective design of vectors for cancer therapy

Gao

Cong

et al. 2022

J. Mater. Chem. B

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“…Furthermore, NPs containing Ag in addition to antimicrobial and cytostatic effects useful in medicine serve as preservatives in the cosmetics industry. When we talk about the interrelationship between nanotechnology and biomedicine, let's not forget about the achievements [30][31][32][33] in the field of human genetic engineering (Figure 9). Without going into details, Figure 8 shows the benefits of nanotechnologies in treatment and diagnosis.…”

Section: Nanotechnology and Biomedicinementioning

confidence: 99%

Nanotechnology: Reflections on Health Benefits and Risks

Buzdugan¹

2022

JES

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There is a constant increase in the demand for engineers who can transform nanotechnology from a scientific result into a commercial solution. However, new technologies often caused conflicts between those who want to exploit them as soon as possible and those who are waiting to receive absolute proof of safety. Certain types of nanoparticles are well studied and recommended for use in medicine, biology, chemistry, cosmetology, etc. Some nanoparticles are proven to be extremely toxic, with drastically different properties from the same volume compounds. The risks associated with using nanotechnologies and products containing nanoparticles cannot be minimized in the absence of regulations, which would allow adequate control to protect the environment and the population’s health. Companies are also extremely careful in investing in this field as long as there is no transparent regulation, as the ultimate goal is to protect the surrounding environment and society. In this paper, we present an overview of the benefits of nanotechnology in areas that affect human health, as well as the risks that may arise from the early use or ill-will of nanotechnologies.

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“…6 In the last couple of decades, we have been witnessing a good deal of effort devoted to designing and developing cutting-edge tools and materials to transfer NAs into cells. 7 Cationic lipids and polymers, collectively called transfection reagents, are very popular because they are reasonably effective in transfecting cells and the most userfriendly. Indeed, they spontaneously assemble with anionic NAs in a vial to form lipoplexes and polyplexes, respectively, which are next dripped onto cell cultures to deliver their payload intracellularly.…”

Section: Introductionmentioning

confidence: 99%

“…6 In the last couple of decades, we have been witnessing a good deal of effort devoted to designing and developing cutting-edge tools and materials to transfer NAs into cells. 7…”

Section: Introductionmentioning

confidence: 99%