Nanotechnology-Based Topical Drug Delivery Systems for Management of Dandruff and Seborrheic Dermatitis: An overview

Thomas, Lena Murad; Khasraghi, Abeer H.

doi:10.31351/vol29iss1pp12-32

Cited by 6 publications

(3 citation statements)

References 110 publications

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“…[26]Despite the increased therapeutic efficacy of liposomes, traditional liposomes are limited to the top layer of skin and are unable to penetrate deeper. [27]…”

Section: Liposomesmentioning

confidence: 99%

“…[33] It is simple for drugs that are hydrophilic, lipophilic, or amphiphilic to get into ethosomes, where they may pass through the deeper epidermal layers and into circulation. [27] Because of its polar character, ethanol is a solvent that may interact directly with the stratum corneum's polar phospholipid head to lower the stratum corneum's melting point and increase drug absorption. [34]The ethanol in the ethosome crosses intracellular lipids, increasing the number of lipids that may dissolve in the cell membrane while decreasing the amount of lipid density in the membrane cell layer.…”

Section: Ethosomesmentioning

confidence: 99%

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Transfersomes as a Surfactant-based Ultradeformable Liposome

Sharma,

Yadav,

Tickoo

et al. 2024

BIO Web Conf.

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In the modern era, there are numerous ways for drug delivery. The change in time has led to the progress of drug delivery systems gaining significant development. Even though most of the drugs are administered orally i.e., in conventional dosage form it has its limitations too like poor patient compliance, metabolism in the liver's first passage, poor absorption, and fluctuations in plasma level.Because our skin is indeed the largest organ, transdermal medication administration has received increased attention in recent years. Many lipids nanovesicles like Liposomes, Niosome, Ethosome, and Transfersomes have been developed as a carrier for transdermal drug delivery. But out of them, Transfersomes are the ones which are of great interest as they show better permeation among all as most of the other carriers cannot pass through the stratum corneum. The method of transdermal medication administration has been used to provide controlled and targeted action and can act as topical and dermal preparation. This review provides basic information about Transfersomes, their mechanism of action, applications, and comparison with other lipid nanocarriers.

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“…[26]Despite the increased therapeutic efficacy of liposomes, traditional liposomes are limited to the top layer of skin and are unable to penetrate deeper. [27]…”

Section: Liposomesmentioning

confidence: 99%

Section: Ethosomesmentioning

confidence: 99%

Transfersomes as a Surfactant-based Ultradeformable Liposome

Sharma,

Yadav,

Tickoo

et al. 2024

BIO Web Conf.

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“…Nanotechnology can help with dental caries prevention and management by reducing plaque and assisting with initial caries remineralization. This engineering specialty used molecular machines with precise structures that are equivalent to nano means 10 -9 , because of their distinctive properties, such as their better surface-to-volume ratio and enhanced bioavailability toward cells and tissues (2,3) . Due to metal nanomaterial's ability to disrupt bacterial metabolism and inhibit biofilm development, significant antibacterial action was displayed by metal and metal oxide nanoparticles (NPs) through metal ion release, oxidative stress generation, and non-oxidative processes (4,5) .…”

Section: Introductionmentioning

confidence: 99%

Improvement of Human Dental Enamel Using Laser-Prepared Indium Oxide Nanoparticles Suspension Solution (In Vitro Study)

Hasan¹,

Abbas²,

Al-Ghurabi³

2023

The Egyptian Journal of Hospital Medicine

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Background: Despite the fact that fluoride-based remineralization technologies have dominated preventive dentistry for the past century, but new and innovative nanomaterials approaches are transforming the industry. A variety of unique nanomaterials are now easily available to assist remineralization of dental enamel surface. Objective: investigate the effect of indium oxide nanoparticles application in comparison to de-ionized water and sodium fluoride on human tooth enamel by assessing the morphological changes in enamel ultra-structure. Using a field emission scanning electron microscope, x-ray diffraction, and ultraviolet visible absorption to evaluate the physical characteristics of indium oxide nanoparticles created by laser ablation in liquid. Method: Teeth samples were seventy-two divided randomly into two phases; each phase consists of study and treated groups with indium oxide nanoparticles, control positive treated with sodium fluoride, and control negative with deionized water. Each group was consisted of twelve teeth, from each group two teeth for scanning electron microscopy and the rests were for energy dispersion spectroscopy. Result: result showed change in chemical composition of dental enamel was recorded for both preventive and treatment groups after nanoparticles application and this was supported by energy dispersive spectroscopy and scanning electron microscope. Conclusion: Laser prepared indium oxide nanoparticles colloidal suspensions were found to be effective remineralizing agent to dental enamel and thus can be considered as an alternative to sodium fluoride mouth wash.

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Encapsulation of Microalgae Tisochrysis lutea Extract in Nanostructured Lipid Carriers (NLCs) and Evaluation of Their Sunscreen, Wound Healing, and Skin Hydration Properties

Chatzopoulou,

Chaikali,

Mourkogianni

et al. 2024

Marine Drugs

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Traditional sunscreens have relied on synthetic compounds to protect against harmful ultraviolet (UV) radiation. However, there is increasing interest in utilizing the natural photoprotective properties of microalgae extracts. This approach does not only aim to enhance the stability and efficacy of sun protection formulae but also seeks to reduce the reliance on synthetic sunscreens. This study investigates the encapsulation of Tisochrysis lutea extract (TL) in nanostructured lipid carriers (NLCs) to create a combination (NLC-TL) with enhanced physicochemical stability, antioxidant activity, SPF efficacy, wound healing capacity, and skin hydration. The particle size and ζ-potential were approximately 100 nm and −50 mV, respectively, and both formulations successfully passed the stability tests. The antioxidant activity, measured via DPPH assay, revealed that NLC-TL achieved the highest free radical scavenging activity across all tested concentrations, indicating a synergistic effect. The incorporation of TL in NLCs maintained the sun protection factor (SPF) of a 2% extract solution (1.53 ± 0.13). The wound healing assay indicated that NLC-TLs significantly enhanced wound closure compared to controls and TL alone. Additionally, skin hydration tests on healthy volunteers revealed that NLC-TLs provided superior and sustained hydration effects. These results highlight NLC-TLs’ potential as a multifunctional topical agent for cosmetic and therapeutic applications.

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Nanotechnology-Based Topical Drug Delivery Systems for Management of Dandruff and Seborrheic Dermatitis: An overview

Cited by 6 publications

References 110 publications

Transfersomes as a Surfactant-based Ultradeformable Liposome

Transfersomes as a Surfactant-based Ultradeformable Liposome

Improvement of Human Dental Enamel Using Laser-Prepared Indium Oxide Nanoparticles Suspension Solution (In Vitro Study)

Encapsulation of Microalgae Tisochrysis lutea Extract in Nanostructured Lipid Carriers (NLCs) and Evaluation of Their Sunscreen, Wound Healing, and Skin Hydration Properties

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