Nanotechnology: Breaking the Current Treatment Limits of Lung Cancer

Li, Shilin; Xu, Shanshan; Liang, Xiaoyu; Xue, Yueguang; Mei, Jie; Ma, Yongfu; Liu, Yang; Liu, Ying

doi:10.1002/adhm.202100078

Cited by 57 publications

(22 citation statements)

References 83 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The tumor-associated antigens released from the broken tumor tissue are processed and presented by the antigen-presenting cells (APCs), which are then delivered to T cells to produce an immune response. Of course, original tumor tissue can also transmit signals to APC for immune response (Li et al 2021 ) (Fig. 1 ).…”

Section: Application Of Nanoparticles In the Treatment Of Lung Cancermentioning

confidence: 99%

Nanoparticles advanced from preclinical studies to clinical trials for lung cancer therapy

et al. 2023

View full text Add to dashboard Cite

Lung cancer is the leading cause of cancer mortality. As a heterogeneous disease, it has different subtypes and various treatment modalities. In addition to conventional surgery, radiotherapy and chemotherapy, targeted therapy and immunotherapy have also been applied in the clinics. However, drug resistance and systemic toxicity still cannot be avoided. Based on the unique properties of nanoparticles, it provides a new idea for lung cancer therapy, especially for targeted immunotherapy. When nanoparticles are used as carriers of drugs with special physical properties, the nanodrug delivery system ensures the accuracy of targeting and the stability of drugs while increasing the permeability and the aggregation of drugs in tumor tissues, showing good anti-tumor effects. This review introduces the properties of various nanoparticles including polymer nanoparticles, liposome nanoparticles, quantum dots, dendrimers, and gold nanoparticles and their applications in tumor tissues. In addition, the specific application of nanoparticle-based drug delivery for lung cancer therapy in preclinical studies and clinical trials is discussed.

show abstract

Section: Application Of Nanoparticles In the Treatment Of Lung Cancermentioning

confidence: 99%

Nanoparticles advanced from preclinical studies to clinical trials for lung cancer therapy

et al. 2023

View full text Add to dashboard Cite

show abstract

“…Nanomedicine is emerging as a new method that does not produce drug resistance, can prevent tumor metastasis and recurrence, and has low toxicity ( Markman et al, 2013 ; Hussain 2016 ; Li et al, 2021 ). It was recently shown that nanomedicine endocytosis has better treatment effect and weak side effects after accumulation in tumor tissues through passive enhanced permeability and retention (EPR) action of tumors ( Nehoff et al, 2014 ).…”

Section: Introductionmentioning

confidence: 99%

Metal-polyphenol polymer modified polydopamine for chemo-photothermal therapy

Luo

Liu

et al. 2023

Front. Chem.

View full text Add to dashboard Cite

Chemotherapy combined with photothermal therapy (PTT) is a new way to improve the curative effect of cancer treatment. Here, we developed a multifunctional nanoparticle, namely PTX@mPDA@Fe-GA with the loading of a chemotherapeutic drug paclitaxel (PTX) for targeted and synergistic chemotherapy/photothermal therapy in lung cancer. Fe-gallic acid (Fe-GA) was coated on the surface of mesoporous polydopamine (mPDA) nanoparticles, and then the PTX was placed in the mesopores. The drug release of the loaded PTX exhibited pH- and thermal-dual responsive manner. Both mPDA and Fe-GA have high photothermal conversion ability and play a role in photothermal therapy. In addition, the results revealed that mPDA@Fe-GA had excellent biocompatibility and low hemolysis rate. The PTX-loaded mPDA@Fe-GA not only has excellent killing effect on lung cancer cells (A549) in vitro, but also can significantly suppress the growth of A549 subcutaneous tumor in nude mice. In a nutshell, the developed multifunctional nanoparticles integrate photothermal therapy and efficient chemotherapeutic drug delivery, providing new therapeutic ideas in the fight against lung cancer.

show abstract

“…The employment of nano-based drug delivery system (DDS) opened a new avenue to integrate multiple anticancer agents in one platform for more efficacious therapeutic outcome with reduced side effects and enhanced targeting ability [ 11 – 13 ]. Due to their unique potential for passive targeting through enhanced permeability and retention (EPR), high surface area for drug loading and modification, and prolonged plasma half-life, nanomedicine possesses numerous benefits over the conventional therapeutic modalities [ 14 – 16 ]. In this field, many nanocarriers like liposomes, micelles, reconstituted high-density lipoprotein (rHDL), metallic NPs, hybrid NPs, nanogel, nanoemulsion, black phosphorus, carbon-related nanomaterials, and other inorganic nanomaterials have been extensively explored in anticancer drug delivery both clinically and pre-clinically [ 17 – 19 ].…”

Section: Introductionmentioning

confidence: 99%

Insights on functionalized carbon nanotubes for cancer theranostics

et al. 2021

View full text Add to dashboard Cite

Despite the exciting breakthroughs in medical technology, cancer still accounts for one of the principle triggers of death and conventional therapeutic modalities often fail to attain an effective cure. Recently, nanobiotechnology has made huge advancement in cancer therapy with gigantic application potential because of their ability in achieving precise and controlled drug release, elevating drug solubility and reducing adverse effects. Carbon nanotubes (CNTs), one of the most promising carbon-related nanomaterials, have already achieved much success in biomedical field. Due to their excellent optical property, thermal and electronic conductivity, easy functionalization ability and high drug loading capacity, CNTs can be applied in a multifunctional way for cancer treatment and diagnosis. In this review, we will give an overview of the recent progress of CNT-based drug delivery systems in cancer theranostics, which emphasizes their targetability to intracellular components of tumor cells and extracellular elements in tumor microenvironment. Moreover, a detailed introduction on how CNTs penetrate inside the tumor cells to reach their sites of action and achieve the therapeutic effects, as well as their diagnostic applications will be highlighted. Graphic Abstract

show abstract

Nanotechnology: Breaking the Current Treatment Limits of Lung Cancer

Cited by 57 publications

References 83 publications

Nanoparticles advanced from preclinical studies to clinical trials for lung cancer therapy

Nanoparticles advanced from preclinical studies to clinical trials for lung cancer therapy

Metal-polyphenol polymer modified polydopamine for chemo-photothermal therapy

Insights on functionalized carbon nanotubes for cancer theranostics

Contact Info

Product

Resources

About