Nanotechnology Controlled Local Drug Delivery System for the Treatment of Periodontitis

Garg, Vishal; Chawla, Kirti; Pawar, Simran

doi:10.9734/jammr/2018/40828

Cited by 9 publications

(7 citation statements)

References 49 publications

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“…Among various nanoparticles used for all the above-mentioned purposes, the metallic AgNPs are contemplated as the most promising, as they possess remarkable antimicrobial properties due to their greater surface area to volume ratio, which is of curiosity for researchers due to the growing microbial resistance against metal ions and antibiotics and the development of resistant strains [15]. Nanoparticles are seen as a solution to many technologies and environmental challenges [10,[16][17][18]. The biological synthesis methods of NPs reduce hazards to the global efforts.…”

Section: Introductionmentioning

confidence: 99%

Biogenic Synthesis of Silver Nanoparticles, Characterization and Their Applications—A Review

2021

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With the growing awareness for the need of sustainable environment, the importance of synthesizing and the application of green nanoparticles has gained special focus. Among various metal nanoparticles, silver nanoparticles (AgNPs) have gain significant attention. AgNPs are synthesized conventionally by physical and chemical methods using chemicals such as reducing agents, which are hazardous to environment due to their toxic properties, provoking a serious concern to create and develop environment friendly methods. Thus, biological alternatives are emerging to fill gaps, such as green syntheses that use biological molecules taken from plant sources in the form of extracts, which have shown to be superior to chemical and physical approaches. These biological molecules derived from plants are assembled in a highly regulated manner to make them suitable for metal nanoparticle synthesis. The current review outlines the wide plant diversity that may be used to prepare a rapid and single-step procedure with a green path over the traditional ones, as well as their antifungal activity.

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Section: Introductionmentioning

confidence: 99%

Biogenic Synthesis of Silver Nanoparticles, Characterization and Their Applications—A Review

2021

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“…Polydopamine (PDA) was coated onto nanofibrous membranes made of polycaprolactone (ε-caprolactone), a biocompatible polymer. The coating attracted calcium and phosphate ions, causing early bone mineralisation [ 32 ].…”

Section: Reviewmentioning

confidence: 99%

“…The safe application of nanotechnology in dentistry is dependent on regulatory considerations. Regulatory agencies should create severe rules for approving and monitoring nanodental products, as pointed out by Garg et al [ 32 ]. Regulators monitor nanomaterials to ensure they are devoid of harmful substances and adhere to strict safety guidelines.…”

Section: Reviewmentioning

confidence: 99%

Clinical Implications of Nanosciences in Dentistry and Periodontics: A Narrative Review

Agrawal,

Bajaj,

Shirbhate

et al. 2023

Cureus

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The nanosciences have recently emerged as a transformative force in dentistry and periodontics, offering fresh strategies to further the development of dental care. This paper provides a concise summary of the effect of nanoparticles, their categorisation, several methods of action, and various dental uses. This review discusses the properties of nanoparticles that lend to their use in dentistry and traces the history of the growth and advancement of nanotechnology in this area, nanomaterials' role in improving dental restorations' durability, aesthetics, and overall dental health by drawing on particular examples from restorative dentistry, prosthodontics, cosmetic dentistry, and general dentistry. In addition, the advancement of nanosciences has made periodontal regeneration easier, which has resulted in more accurate forecasting of its effects. Issues relating to safety, finances, and regulations imposed by the government have been fixed. It is encouraged that research be conducted into the full potential of nanosciences in dentistry and periodontics as a method of realising the field's bright future. Applications of nanotechnology in dentistry and periodontics can be broadly discussed under the prevention, detection, and treatment modalities.

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“…Its pKa values are 2.2 and 10.3, which render it di-cationic over the entire range of physiological pH values [45][46][47]. Several groups have investigated the potential use of ES mats for the local delivery of antibiotics, such as doxycycline, metronidazole, tetracycline, minocycline, and CHX [48,49].…”

Section: Introductionmentioning

confidence: 99%

Development and Characterization of pH-Dependent Cellulose Acetate Phthalate Nanofibers by Electrospinning Technique

et al. 2021

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The aim of this work was to obtain pH-dependent nanofibers with an electrospinning technique as a novel controlled release system for the treatment of periodontal disease (PD). Cellulose acetate phthalate (CAP) was selected as a pH-sensitive and antimicrobial polymer. The NF was optimized according to polymeric dispersion variables, polymer, and drug concentration, and characterized considering morphology, diameter, entrapment efficiency (EE), process efficiency (PE), thermal properties, and release profiles. Two solvent mixtures were tested, and CHX-CAP-NF prepared with acetone/ethanol at 12% w/v of the polymer showed a diameter size of 934 nm, a uniform morphology with 42% of EE, and 55% of PE. Meanwhile, CHX-CAP-NF prepared with acetone/methanol at 11% w/v of polymer had a diameter of 257 nm, discontinuous nanofiber morphology with 32% of EE, and 40% of PE. EE and PE were dependent on the polymer concentration and the drug used in the formulation. Studies of differential scanning calorimetry (DSC) showed that the drug was dispersed in the NF matrix. The release profiles of CHX from CHX-CAP-NF followed Fickian diffusion dependent on time (t0.43−0.45), suggesting a diffusion–erosion process and a matrix behavior. The NF developed could be employed as a novel drug delivery system in PD.

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Nanotechnology Controlled Local Drug Delivery System for the Treatment of Periodontitis

Cited by 9 publications

References 49 publications

Biogenic Synthesis of Silver Nanoparticles, Characterization and Their Applications—A Review

Biogenic Synthesis of Silver Nanoparticles, Characterization and Their Applications—A Review

Clinical Implications of Nanosciences in Dentistry and Periodontics: A Narrative Review

Development and Characterization of pH-Dependent Cellulose Acetate Phthalate Nanofibers by Electrospinning Technique

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