Nanotechnology for Dental Implants

Tomsia, Antoni P.; Lee, Janice S.; Wegst, Ulrike G. K.; Saiz, Eduardo

doi:10.11607/jomi.te34

Cited by 86 publications

(83 citation statements)

References 126 publications

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“…[17][18][19][20] Recently, nanotopography modification of titanium substrates for accelerating tissue healing has become a major focus of interest. 21,22 Several methods have been developed to produce nanotopography, among which chemical treatment (eg, alkali treatment) is widely used due to its good operability and flexibility. 23,24 In our previous work, a homogeneous nanofiber structure was prepared by alkali-hydrothermal treatment (NaOH and H 2 O 2 ), and this method showed enhanced osteogenic activity of osteoblasts in comparison to implants with a smooth surface.…”

Section: Introductionmentioning

confidence: 99%

The response of human osteoblasts, epithelial cells, fibroblasts, macrophages and oral bacteria to nanostructured titanium surfaces: a systematic study

Miao¹,

Wang²,

Xu³

et al. 2017

IJN

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Nanotopography modification is a major focus of interest in current titanium surface design; however, the influence of the nanostructured surface on human cell/bacterium behavior has rarely been systematically evaluated. In this study, a homogeneous nanofiber structure was prepared on a titanium surface (Nano) by alkali-hydrothermal treatment, and the effects of this Nano surface on the behaviors of human MG-63 osteoblasts, human gingival epithelial cells (HGECs) and human gingival fibroblasts (HGFs) were evaluated in comparison with a smooth titanium surface (Smooth) by polishing and a micro-rough titanium surface (Micro) by sandblasting and acid etching. In addition, the impacts of these different surface morphologies on human THP-1 macrophage polarization and Streptococcus mutans attachment were also assessed. Our findings showed that the nanostructured surface enhanced the osteogenic activity of MG-63 cells (Nano=Micro>Smooth) at the same time that it improved the attachment of HGECs (Nano>Smooth>Micro) and HGFs (Nano=Micro>Smooth). Furthermore, the surface with nanotexture did not affect macrophage polarization (Nano=Micro=Smooth), but did reduce initial bacterial adhesion (Nano

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Section: Introductionmentioning

confidence: 99%

The response of human osteoblasts, epithelial cells, fibroblasts, macrophages and oral bacteria to nanostructured titanium surfaces: a systematic study

Miao¹,

Wang²,

Xu³

et al. 2017

IJN

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“…78 The potential application of nanotechnology in dentistry is the development of the long-lasting biocompatible dental implants with improved osseointegration and mechanical properties. 79 These surface-modified implants have the potential of effectively replacing, both structurally and functionally, the worn-out tooth and are being increasingly recognized as the most promising option for dental regeneration. A schematic diagram showing surface modification of dental implants for improved implant performance is depicted in Figure 4.…”

Section: Dental Regenerationmentioning

confidence: 99%

Regenerative nanomedicine: current perspectives and future directions

Chaudhury¹,

Kumar²,

Kandasamy³

et al. 2014

IJN

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Nanotechnology has considerably accelerated the growth of regenerative medicine in recent years. Application of nanotechnology in regenerative medicine has revolutionized the designing of grafts and scaffolds which has resulted in new grafts/scaffold systems having significantly enhanced cellular and tissue regenerative properties. Since the cell–cell and cell-matrix interaction in biological systems takes place at the nanoscale level, the application of nanotechnology gives an edge in modifying the cellular function and/or matrix function in a more desired way to mimic the native tissue/organ. In this review, we focus on the nanotechnology-based recent advances and trends in regenerative medicine and discussed under individual organ systems including bone, cartilage, nerve, skin, teeth, myocardium, liver and eye. Recent studies that are related to the design of various types of nanostructured scaffolds and incorporation of nanomaterials into the matrices are reported. We have also documented reports where these materials and matrices have been compared for their better biocompatibility and efficacy in supporting the damaged tissue. In addition to the recent developments, future directions and possible challenges in translating the findings from bench to bedside are outlined.

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“…structure-property relationship | structural biomaterial | biocomposite | variational analysis B iological structural materials such as nacre, tooth, bone, and fish scales (1-9) often exhibit remarkable mechanical properties, which can be directly attributed to their unique structure and composition (10)(11)(12)(13)(14)(15). Through the detailed analysis of these complex skeletal materials, useful design lessons can be extracted that can be used to guide the synthesis of synthetic constructs with novel performance metrics (16)(17)(18)(19)(20). The complex and mechanically robust cage-like skeletal system of the hexactinellid sponge Euplectella aspergillum has proved to be a particularly useful model system for investigating structure-function relationships in hierarchically ordered biological composites (21)(22)(23)(24)(25).…”

mentioning

confidence: 99%

New functional insights into the internal architecture of the laminated anchor spicules of Euplectella aspergillum

Monn

Weaver

Zhang

et al. 2015

Proc. Natl. Acad. Sci. U.S.A.

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To adapt to a wide range of physically demanding environmental conditions, biological systems have evolved a diverse variety of robust skeletal architectures. One such example, Euplectella aspergillum, is a sediment-dwelling marine sponge that is anchored into the sea floor by a flexible holdfast apparatus consisting of thousands of anchor spicules (long, hair-like glassy fibers). Each spicule is covered with recurved barbs and has an internal architecture consisting of a solid core of silica surrounded by an assembly of coaxial silica cylinders, each of which is separated by a thin organic layer. The thickness of each silica cylinder progressively decreases from the spicule's core to its periphery, which we hypothesize is an adaptation for redistributing internal stresses, thus increasing the overall strength of each spicule. To evaluate this hypothesis, we created a spicule structural mechanics model, in which we fixed the radii of the silica cylinders such that the force transmitted from the surface barbs to the remainder of the skeletal system was maximized. Compared with measurements of these parameters in the native sponge spicules, our modeling results correlate remarkably well, highlighting the beneficial nature of this elastically heterogeneous lamellar design strategy. The structural principles obtained from this study thus provide potential design insights for the fabrication of high-strength beams for load-bearing applications through the modification of their internal architecture, rather than their external geometry. structure-property relationship | structural biomaterial | biocomposite | variational analysis B iological structural materials such as nacre, tooth, bone, and fish scales (1-9) often exhibit remarkable mechanical properties, which can be directly attributed to their unique structure and composition (10)(11)(12)(13)(14)(15). Through the detailed analysis of these complex skeletal materials, useful design lessons can be extracted that can be used to guide the synthesis of synthetic constructs with novel performance metrics (16)(17)(18)(19)(20). The complex and mechanically robust cage-like skeletal system of the hexactinellid sponge Euplectella aspergillum has proved to be a particularly useful model system for investigating structure-function relationships in hierarchically ordered biological composites (21-25). The sponge is anchored to the sea floor by thousands of anchor spicules (long, hair-like skeletal elements), each of which measures ca. 50 μm in diameter and up to 10 cm in length ( Fig. 1 A and B). The distal end of each anchor spicule is capped with a terminal crown-like structure and is covered with a series of recurved barbs that secure the sponge into the soft sediments of the sea floor (Fig. 1C). The proximal regions of these spicules are in turn bundled together and cemented to the main vertical struts of the skeletal lattice.These spicules contain an elastically heterogeneous, lamellar internal structure and are composed of amorphous hydrated silica. Surrounding a thin ...

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Nanotechnology for Dental Implants

Cited by 86 publications

References 126 publications

The response of human osteoblasts, epithelial cells, fibroblasts, macrophages and oral bacteria to nanostructured titanium surfaces: a systematic study

The response of human osteoblasts, epithelial cells, fibroblasts, macrophages and oral bacteria to nanostructured titanium surfaces: a systematic study

Regenerative nanomedicine: current perspectives and future directions

New functional insights into the internal architecture of the laminated anchor spicules of Euplectella aspergillum

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