Nanotechnology for the detection and kill of circulating tumor cells

Gao, Yang; Zhang, Yuan

doi:10.1186/1556-276x-9-500

Cited by 12 publications

(4 citation statements)

References 80 publications

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“…The recent studies found that the newly emerging nanotechnology has broad prospects in CTCs' research and could be a promising approach to kill CTCs with a high efficiency. The nanoparticles combined with apoptosis-related molecules such as TRAIL, TNF, FasL, and liposomes with encapsulated siRNA will prolong the overall survival of the patients with malignancy [ 35 , 54 ]. In addition, some mutated or abnormally expressed genes associated with CTCs survival may be new targets for cancer therapy.…”

Section: New Treatment Strategies Targeting the Survival Mechanismmentioning

confidence: 99%

Survival Mechanisms and Influence Factors of Circulating Tumor Cells

Wang

Peng

et al. 2018

BioMed Research International

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Circulating tumor cells (CTCs) are cancer cells shed from either the primary tumor or its metastases that circulate in the peripheral blood. The CTCs are regarded as the source of tumor recurrence and metastasis and speculated as the indicators of residual tumors, thereby indicating a poor prognosis. Although CTCs play a vital role in tumor metastasis and recurrence, little is known about the underlying survival mechanisms in the blood circulation. The accumulating evidence has revealed that CTCs might survive in the peripheral blood by overcoming the mechanical damage due to shear stress, resistance to anoikis, evasion of immune destruction, and resistance to chemotherapy. The present review addresses the putative survival mechanisms underlying the formation and migration of CTCs according to their biological characteristics and blood microenvironment. In addition, the relationship between CTCs and microenvironment is illustrated, and the influencing factors related to the interactions of CTCs with various components in the peripheral blood are reviewed with respect to the platelets, immune cells, cytokines, and circulating tumor microemboli (CTM). Furthermore, the recent advances in the new treatment strategies targeting the survival mechanisms of CTCs are also discussed.

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Section: New Treatment Strategies Targeting the Survival Mechanismmentioning

confidence: 99%

Survival Mechanisms and Influence Factors of Circulating Tumor Cells

Wang

Peng

et al. 2018

BioMed Research International

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“…Migration of CTCs to specific organs is regulated by complex factors driven by cell microenvironment at those sites (Gao and Yuan, 2014). Approaches to recruit CTCs have focused on both mimicking the microenvironment of a target organ (Lee et al, 2012;Moreau et al, 2007) (i.e., bone microenvironment for breast cancer metastasis), through the local immune modulation of implantable scaffolds (Azarin et al, 2015;Erler et al, 2009) and by modulating the cell adhesion properties of biomaterials surface (Gao and Yuan, 2014). Very recently, it has been demonstrated that the immune response upon PLGA-based scaffold implantation implies massive macrophages and neutrophils infiltration, forming a "pre-metastatic niche" inclined to recruit CTCs and tumorassociated cells (Gower et al, 2014;Graham et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Enhanced adhesion and in situ photothermal ablation of cancer cells in surface-functionalized electrospun microfiber scaffold with graphene oxide

Mauro

Scialabba

Pitarresi

et al. 2017

International Journal of Pharmaceutics

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The physicochemical characteristics of a biomaterial surface highly affect the interaction with living cells. Recently, much attention has been focused on the adhesion properties of functional biomaterials toward cancer cells, since is expected to control metastatic spread of a tumor, which is related to good probability containing the progression of disease burden. Here, we designed an implantable poly(caprolactone)-based electrospun microfiber scaffold, henceforth PCL-GO, to simultaneously capture and kill cancer cells by tuning physicochemical features of the hybrid surface through nitrogen plasma activation and hetero-phase graphene oxide (GO) covalent functionalization. The surface immobilization of GO implies enhanced cell adhesion and proliferation, promoting the selective adhesion of cancer cells, even if allowing cancer associated fibroblast (CAFs) capture. We also display that the functionalization with GO, thanks to the high near-infrared (NIR) absorbance, enables the discrete photothermal eradication of the captured cancer cells in situ (≈98%).

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“…The efficacy of cancer treatments largely depends on the extent to which the tumor spreads [1,2]. Detecting the tumor in the early stages makes treatment much easier and also elevates the chances of recovery [3][4][5]. There are various transformations that happen at the molecular and cellular levels before a cancer matures and appears at the tissue and organ levels [2,3].…”

Section: Introductionmentioning

confidence: 99%

Electromechanical transducer for rapid detection, discrimination and quantification of lung cancer cells

Ali¹,

Moghaddam²,

Raza³

et al. 2016

Nanotechnology

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Tumor cells are malignant derivatives of normal cells. There are characteristic differences in the mechanophysical properties of normal and tumor cells, and these differences stem from the changes that occur in the cell cytoskeleton during cancer progression. There is a need for viable whole blood processing techniques for rapid and reliable tumor cell detection that do not require tagging. Micropore biosensors have previously been used to differentiate tumor cells from normal cells and we have used a micropore-based electromechanical transducer to differentiate one type of tumor cells from the other types. This device generated electrical signals that were characteristic of the cell properties. Three non-small cell lung cancer (NSCLC) cell lines, NCl-H1155, A549 and NCI-H460, were successfully differentiated. NCI-H1155, due to their comparatively smaller size, were found to be the quickest in translocating through the micropore. Their translocation through a 15 μm micropore caused electrical pulses with an average translocation time of 101 ± 9.4 μs and an average peak amplitude of 3.71 ± 0.42 μA, whereas translocation of A549 and NCI-H460 caused pulses with average translocation times of 126 ± 17.9 μs and 148 ± 13.7 μs and average peak amplitudes of 4.58 ± 0.61 μA and 5.27 ± 0.66 μA, respectively. This transformation of the differences in cell properties into differences in the electrical profiles (i.e. the differences in peak amplitudes and translocation times) with this electromechanical transducer is a quantitative way to differentiate these lung cancer cells. The solid-state micropore device processed whole biological samples without any pre-processing requirements and is thus ideal for point-of-care applications.

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Nanotechnology for the detection and kill of circulating tumor cells

Cited by 12 publications

References 80 publications

Survival Mechanisms and Influence Factors of Circulating Tumor Cells

Survival Mechanisms and Influence Factors of Circulating Tumor Cells

Enhanced adhesion and in situ photothermal ablation of cancer cells in surface-functionalized electrospun microfiber scaffold with graphene oxide

Electromechanical transducer for rapid detection, discrimination and quantification of lung cancer cells

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