2017
DOI: 10.1186/s11671-017-2249-8
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Nanotechnology: from In Vivo Imaging System to Controlled Drug Delivery

Abstract: Science and technology have always been the vitals of human’s struggle, utilized exclusively for the development of novel tools and products, ranging from micro- to nanosize. Nanotechnology has gained significant attention due to its extensive applications in biomedicine, particularly related to bio imaging and drug delivery. Various nanodevices and nanomaterials have been developed for the diagnosis and treatment of different diseases. Herein, we have described two primary aspects of the nanomedicine, i.e., i… Show more

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Cited by 109 publications
(55 citation statements)
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“…Over the past couple of decades pharmaceutical nanotechnology have received considerable attention and demonstrated significant potential for the development of innovative medicinal products both for the therapy and the diagnosis of severe diseases [59]. In this work, we report a new preparation method of lipid-core PCL nanocapsules, optimizing a two-step process (self-assembly step followed by a coating step) into a one-pot technique to develop chitosan-coated nanoparticles.…”
Section: Discussionmentioning
confidence: 99%
“…Over the past couple of decades pharmaceutical nanotechnology have received considerable attention and demonstrated significant potential for the development of innovative medicinal products both for the therapy and the diagnosis of severe diseases [59]. In this work, we report a new preparation method of lipid-core PCL nanocapsules, optimizing a two-step process (self-assembly step followed by a coating step) into a one-pot technique to develop chitosan-coated nanoparticles.…”
Section: Discussionmentioning
confidence: 99%
“…The recent improvements in nanotechnology proved better results for tumor diagnostics, imaging and site specific delivery. 130 Nanocarriers are also used for increasing the dose-dependent efficacy of therapeutic or imaging contrast agents by enhancing their bioavailability. Similarly, they are used for selected targeting of tumor cells to upsurge image resolution and/or decrease the toxic effects of the chemotherapeutic agents.…”
mentioning
confidence: 99%
“…164 Phytosome is a patented formula developed to incorporate medicinal plant active ingredients and water-soluble phytochemicals into phospholipids to create lipid-compatible molecular complexes in order to immensely modify their absorption and bioavailability. 165 The novelty of phytosome formulation is that there is a molecular complex and chemical bonding between phosphatidylcholine and the plant materials at a ratio of either 1:1 or a 2:1 relying on the substance(s) conjugated, whereas no chemical bonds are formed in liposome and thousands of phosphatidylcholine molecules enclosing the water-soluble compound can be observed freely. 166 Phytolipid delivery system is a specifically modified phytosome for delivering of herbal drugs that made by incorporation of standardized plant extracts or water-soluble phytochemicals into phospholipids to produce lipidcompatible complexes to enhance better absorption and bioavailability without resorting the pharmacological or structural changes of the ingredients.…”
Section: Micellementioning
confidence: 99%