Nanotechnology, from quantum mechanical calculations up to drug delivery

Abstract

There are several reasons why nanotechnology is currently considered as the leader among the most intensively developing research trends. Nanomatter often exhibits new properties, other than those of the morphology of a continuous solid. Also, new phenomena appear at the nanoscale, which are unknown in the case of microcrystalline objects. For this reason, nanomaterials have already found numerous applications that are described in this review. However, among intensively developed various branches of nanotechnology, nanomedicine and pharmacology stand out particularly, which opens new possibilities for the development of these disciplines, gives great hope for the creation of new drugs in which toxicological properties are reduced to a minimum, reduces the doses of medicines, offers targeted treatment and increases diagnostic possibilities. Nanotechnology is the source of a great revolution in medicine. It gives great hope for better and faster treatment of many diseases and gives hope for a better tomorrow. However, the creation of new “nanodrugs” requires a special understanding of the properties of nanoparticles. This article is a review work which determines and describes the way of creating new nanodrugs from ab initio calculations by docking and molecular dynamic applications up to a new medicinal product, as a proposal for the personalized medicine, in the early future.

Docking of Cisplatin on Fullerene Derivatives and Some Cube Rhombellane Functionalized Homeomorphs

“…There are many types of these structures, among which only those have been used which have functional groups that allow attachment of CisPt ( Figure 3). ful_308a4 ful_308b4 Despite the initially expected chemical inactivity of C60 and its derivatives, it was found that fullerenes can be functionalized [21]. Due to the mode of functionalization, there were distinguished exo-and endohedral forms of fullerenes and heterofullerenes.…”

“…Due to the mode of functionalization, there were distinguished exo-and endohedral forms of fullerenes and heterofullerenes. The essence of Despite the initially expected chemical inactivity of C 60 and its derivatives, it was found that fullerenes can be functionalized [21]. Due to the mode of functionalization, there were distinguished exo-and endohedral forms of fullerenes and heterofullerenes.…”

“…when they have been attached to specific groups of atoms. C 60 and its homologues have interesting and often unique properties, and after functionalization the C 60 molecule can bind any functional group ( Figure 4) [21]. At the same time, it is indifferent, non-toxic and so small that it easily comes into contact with cells, proteins and viruses.…”

The Immobilization of Oxindole Derivatives Using New Designed Functionalized C60 Nanomolecules

“…The development of targeted therapy is frequently related to immobilization of drug molecules by molecular carriers. Such a role can be fulfilled by different classes of molecules like albumin [1], chitosan [2,3], gelatin [4], gold complexes [5,6], hydrogels [7], magnetic iron oxides [8] polymers [9][10][11], cube rhombellanes [12][13][14] and fullerenes and their derivatives [15][16][17][18]. The implementation of such types of methods ensures the direct delivery of drugs and their release to the appropriate biological target.…”

“…Recently, one of the most dynamically developing groups of nanoparticles, applicable not only in medicine and pharmacy, are fullerenes. One of the most commonly used molecules in this group is fullerene C60 [15][16][17][18]22]. The characteristic chemical structure of this molecule increases the binding capacity toward biologically active molecules containing aromatic systems.…”