Nanotechnology in diabetic wound healing

Azeltine, Mark; Clark, Andrew R.; Zgheib, Carlos; Ghatak, Subhadip

doi:10.1016/b978-0-12-816413-6.00021-6

Cited by 4 publications

(4 citation statements)

References 85 publications

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“…The development of nanoneedles and nanotweezers will also enable cell surgery in the near future. 16 Azeltine et al 17 claimed that nanomaterials facilitate and quickens the healing process of wounds.…”

Section: Nanomaterials For the Treatment Of Wound Healing And Bone De...mentioning

confidence: 99%

Nanotechnology - An advanced dental innovation

Sood,

Sharma,

Kaur

et al. 2024

IJPI

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Researchers are interested in exploring the possible uses and advantages of nanotechnology compared to traditional materials, particularly in the domains of dentistry and medicine. The study and creation of materials, tools, systems with distinct biological, chemical, physical characteristics from those found in larger system is known as nanotechnology. Numerous advancements and improvement in oral disease prevention, diagnosis, and treatment are possible because of nanotechnology. Recent Nano - technology breakthrough developments in dentistry are progressively providing a viable therapeutic option for a wide range of dental problems. The purpose of this review was to provide an overview role of nanotechnology in dentistry, as well as to evaluate its application in the prevention and treatment of oral disorders, along with providing crucial new updates on the various nanotechnology – based techniques for dental disease management. The current review will also assist the reader in comprehending Nano science, as well as its benefits and drawbacks, by discussing its ethical, social, and health consequences. In addition, Nano -applications in dental diagnostics and their function in dentistry will be discussed.

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Section: Nanomaterials For the Treatment Of Wound Healing And Bone De...mentioning

confidence: 99%

Nanotechnology - An advanced dental innovation

Sood,

Sharma,

Kaur

et al. 2024

IJPI

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“…16 Hence, it is important to design multifunctional scaffolds to improve wound healing efficacy. 17 Wound healing is one of the great challenges in regenerative medicine. The cumulative functions, including cell proliferation, inflammation, membrane repair, scar formation, tissue remodeling, and angiogenesis, are integral for reconstructing the tissue architecture.…”

Section: ■ Introductionmentioning

confidence: 99%

“…Recently, different scaffolds have been generated for wound healing studies using nanomaterials, proteins, growth factors, and drugs to create an appropriate platform to imitate tissue reconstruction and repair the wounded areas. , Despite these advances, some of the issues, such as scar formation and bacterial infection, are left unaddressed . Hence, it is important to design multifunctional scaffolds to improve wound healing efficacy . Wound healing is one of the great challenges in regenerative medicine.…”

Section: Introductionmentioning

confidence: 99%

Sustained Releasable Copper and Zinc Biogenic Ions Co-Assembled in Metal–Organic Frameworks Reinforced Bacterial Eradication and Wound Mitigation in Diabetic Mice

Amer,

Palanisamy,

et al. 2023

Bioconjugate Chem.

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The employment of metal–organic framework (MOF)-based nanomaterials has been rapidly increasing in bioapplications owing to their biocompatibility, drug degradation, tunable porosity, and intrinsic biodegradability. This evidence suggests that the multifunctional bimetallic ions can behave as remarkable candidates for infection control and wound healing. In this study, bimetallic MOFs (Zn-HKUST-1 and FolA-Zn-HKUST-1) embedded with and without folic acid were synthesized and used for tissue sealing and repairing incisional wound sites in mice models. For comparison, HKUST-1 and FolA-HKUST-1 were also synthesized. The Brunauer–Emmett–Teller (BET) surface area measured for HKUST-1, FolA-HKUST-1, Zn-HKUST-1, and FolA-Zn-HKUST-1 from N2 isotherms was found to be 1868, 1392, 1706, and 1179 m2/g, respectively. The measurements of contact angle values for Zn-HKUST-1, FolA-HKUST-1, and Zn-FolA-HKUST-1 were identified as 4.95 ± 0.8, 43.6 ± 3.4, and 60.62 ± 2.0°, respectively. For topical application in wound healing, they display a wide range of healing characteristics, including antibacterial and enhanced wound healing rates. In addition, in vitro cell migration and tubulogenic potentials were evaluated. The significant reduction in the wound gap and increased expression levels for CD31, eNOS, VEGF-A, and Ki67 were observed from immunohistological analyses to predict the angiogenesis behavior at the incision wound site. The wound healing rate was analyzed in the excisional dermal wounds of diabetic mice model in vivo. On account of antibacterial potentials and tissue-repairing characteristics of Cu2+ and Zn2+ ions, designing an innovative mixed metal ion-based biomaterial has wide applicability and is expected to modulate the growth of various gradient tissues.

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“…Diabetes is a metabolic and worldwide disease that leads to severe health complications and even death. , One of the most common diabetic hitches is inefficient wound healing, which mostly is related to the high blood sugar level. , The prolonged healing of diabetic wounds decreases the activation of fibroblasts, formation of granulation tissues and collagen, and increases developing bacterial infections with amputation risk. − On the other hand, long-term use of antibiotics and nanomaterials with antibacterial properties such as copper and silver ions at the infected sites may induce drug resistance, cytotoxicity, and defective healing. − The defective wound healing in diabetic patients consequently results in death upon infection. − …”

Section: Introductionmentioning

confidence: 99%

Boronic Acid-Functionalized Two-Dimensional MoS₂ at Biointerfaces

et al. 2020

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While noncovalent interactions at two-dimensional nanobiointerfaces are extensively investigated, less knowledge about covalent interactions at this interface is available. In this work, boronic acid-functionalized 2D MoS2 was synthesized and its covalent multivalent interactions with bacteria and nematodes were investigated. Polymerization of glycidol by freshly exfoliated MoS2 and condensation of 2,5-thiophenediylbisboronic acid on the produced platform resulted in boronic acid-functionalized 2D MoS2. The destructive interactions between 2D MoS2 and bacteria as well as nematodes were significantly amplified by boronic acid functional groups. Because of the high antibacterial and antinematodal activities of boronic acid-functionalized 2D MoS2, its therapeutic efficacy for diabetic wound healing was investigated. The infected diabetic wounds were completely healed 10 days after treatment with boronic acid-functionalized 2D MoS2, and a normal structure for recovered tissues including different layers of skin, collagen, and blood vessels was detected.

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Nanotechnology in diabetic wound healing

Cited by 4 publications

References 85 publications

Nanotechnology - An advanced dental innovation

Nanotechnology - An advanced dental innovation

Sustained Releasable Copper and Zinc Biogenic Ions Co-Assembled in Metal–Organic Frameworks Reinforced Bacterial Eradication and Wound Mitigation in Diabetic Mice

Boronic Acid-Functionalized Two-Dimensional MoS₂ at Biointerfaces

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Nanotechnology in diabetic wound healing

Cited by 4 publications

References 85 publications

Nanotechnology - An advanced dental innovation

Nanotechnology - An advanced dental innovation

Sustained Releasable Copper and Zinc Biogenic Ions Co-Assembled in Metal–Organic Frameworks Reinforced Bacterial Eradication and Wound Mitigation in Diabetic Mice

Boronic Acid-Functionalized Two-Dimensional MoS2 at Biointerfaces

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Product

Resources

About

Boronic Acid-Functionalized Two-Dimensional MoS₂ at Biointerfaces