Nanotechnology in interventional cardiology

Cyrus, Tillmann; Wickline, Samuel A.; Lanza, Gregory M.

doi:10.1002/wnan.154

Cited by 18 publications

(11 citation statements)

References 108 publications

(164 reference statements)

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“…A good example in this regard is the recent successful and safe completion of SERCA2 (a protein inactivated by high levels of ROS) gene therapy for the treatment of heart failure [570]. Advances in nanotechnology may help in the detection of activated/dysfunctional endothelium by imaging the inflammatory markers [571–573]. Furthermore, nanotechnology-based drug delivery mechanisms targeted to specific cell types/organs (cardiomyo-cytes/heart) and organelles (mitochondria) may help transform the treatment of CVD and other diseases of oxidative stress.…”

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

Redox signaling in cardiovascular health and disease

Madamanchi

Runge

2013

Free Radical Biology and Medicine

183

142

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Spatiotemporal regulation of the activity of a vast array of intracellular proteins and signaling pathways by reactive oxygen species (ROS) governs normal cardiovascular function. However, data from experimental and animal studies strongly support that dysregulated redox signaling, resulting from hyper-activation of various cellular oxidases or mitochondrial dysfunction, is integral to the pathogenesis and progression of cardiovascular disease (CVD). In this review, we address how redox signaling modulates the protein function, the various sources of increased oxidative stress in CVD, and the labyrinth of redox-sensitive molecular mechanisms involved in the development of atherosclerosis, hypertension, cardiac hypertrophy and heart failure, and ischemia–reperfusion injury. Advances in redox biology and pharmacology for inhibiting ROS production in specific cell types and subcellular organelles combined with the development of nanotechnology-based new in vivo imaging systems and targeted drug delivery mechanisms may enable fine-tuning of redox signaling for the treatment and prevention of CVD.

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Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

Redox signaling in cardiovascular health and disease

Madamanchi

Runge

2013

Free Radical Biology and Medicine

183

142

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“…Therefore, inhibition of vascular thrombosis and restenosis is the primary factor determining long-term success of stent placement. 39 To solve these problems, drug-eluting stents (DES) were invented, especially DES coated with NPs that can help locate previously ineffective drugs in interesting epitopes and produce the desired results. Nakano et al elicited a delivery platform with NP-eluting stent to target prevention of restenosis and improvement of endothelial recovery.…”

Section: Nps In Diagnosis and Treatment Of Coronary Artery Disease (Cad)mentioning

confidence: 99%

Nanotechnology, an alternative with promising prospects and advantages for the treatment of cardiovascular diseases

Li¹,

Liang²,

Xiao³

et al. 2018

IJN

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Cardiovascular diseases (CVDs) are one of the most important causes of mortality and affecting the health status of patients. At the same time, CVDs cause a huge health and economic burden to the whole world. Although a variety of therapeutic drugs and measures have been produced to delay the progress of the disease and improve the quality of life of patients, most of the traditional therapeutic strategies can only cure the symptoms and cannot repair or regenerate the damaged ischemic myocardium. In addition, they may bring some unpleasant side effects. Therefore, it is vital to find and explore new technologies and drugs to solve the shortcomings of conventional treatments. Nanotechnology is a new way of using and manipulating the matter at the molecular scale, whose functional organization is measured in nanometers. Because nanoscale phenomena play an important role in cell signal transduction, enzyme action and cell cycle, nanotechnology is closely related to medical research. The application of nanotechnology in the field of medicine provides an alternative and novel direction for the treatment of CVDs, and shows excellent performance in the field of targeted drug therapy and the development of biomaterials. This review will briefly introduce the latest applications of nanotechnology in the diagnosis and treatment of common CVDs.

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“…They also promote endothelial growth. It is too early to say which of these materials for PCI will prove to be optimal, but it is safe to say that nanotechnology will play a role, whether in stent manufacture or drug delivery …”

Section: Current Surgical Needs—the Tip Of a Large Icebergmentioning

confidence: 99%

What would surgeons like from materials scientists?

Grundfest‐Broniatowski

2013

WIREs Nanomed Nanobiotechnol

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Surgery involves the repair, resection, replacement, or improvement of body parts and functions and in numerous ways, surgery should be considered human engineering. There are many areas in which surgical materials could be improved, but surgeons are generally unaware of materials available for use, while materials scientists do not know what surgeons require. This article will review some of the areas where surgeons and materials scientists have interacted in the past and will discuss some of the most pressing problems which remain to be solved. These include better implant materials for hernia repair, breast reconstruction, the treatment of diabetes, vascular stenting and reconstruction, and electrical pacing devices. The combination of tissue engineering and nanomaterials has great potential for application to nearly every aspect of surgery. Tissue engineering will allow cells or artificial organs to be grown for specific uses while nanotechnology will help to ensure maximal biocompatibility. Biosensors will be combined with improved electrodes and pacing devices to control impaired neurological functions.

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Nanotechnology in interventional cardiology

Cited by 18 publications

References 108 publications

Redox signaling in cardiovascular health and disease

Redox signaling in cardiovascular health and disease

Nanotechnology, an alternative with promising prospects and advantages for the treatment of cardiovascular diseases

What would surgeons like from materials scientists?

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