Nanotechnology in Oral Cavity Carcinoma: Recent Trends and Treatment Opportunities

Felice, Francesca De; Cavallini, Costanza; Barlattani, A; Tombolini, Mario; Brugnoletti, Orlando; Tombolini, Vincenzo; Polimeni, Antonella

doi:10.3390/nano9111546

Cited by 11 publications

(7 citation statements)

References 69 publications

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“…Several NPs have been developed as DDSs in the treatment of OSCC, which included inorganic NPs, extracellular vesicles, polymer NPs, and lipid NPs, cell membrane-based NPs and nanoenzymes ( Calixto et al, 2014 ; Chen et al, 2023a ; Mabrouk et al, 2023 ; Ortega et al, 2023 ). The improved therapeutic effect of NPs combined with anticancer agents has been demonstrated ( De Felice et al, 2019 ). For example, Mukherjee et al (2022) treated OSCC cell line (KB 3-1 cell) for 24 h with cetuximab (a epithelial growth factor receptor (EGFR) inhibitor) and NC in various doses.…”

Section: Different Nps As Ddss In Enhancing the Efficacy Of Anticance...mentioning

confidence: 99%

“…Therefore, more detailed studies are required to evaluate biosafety of all types of NPs. Particularly, there is a lack of ongoing and completed clinical trials in patients with OSCC so far ( De Felice et al, 2019 ), which is a necessary step for the definition of the potential oncology applications of NPs as DDSs in daily clinical practice in the treatment of OSCC in the future. Therefore, how to develop NPs as DDSs in a cheaper, easier, and faster way still remains a technical hurdle.…”

Section: Current Challenges Of the Strategies Of Nps As Ddss In Osccmentioning

confidence: 99%

“…In addition, the use of these free drugs is faced with poor therapeutic efficacy and severe side effects. Therefore, NPs-based therapies become particularly suitable for enhancing the bioavailability of chemotherapeutic drugs and target delivery to the tumor site, which can significantly improve the therapeutic efficacy and reduce side effects ( De Felice et al, 2019 ). In addition, unlike tumors located deeply in the human body, such as colon cancer and liver cancer, OSCC is located at surface such as the buccal mucosa and tongue, which makes that OSCC is suitable for combinational treatment with NPs-mediated/enhanced PDT/PTT ( Fan et al, 2020b ).…”

Section: Current Challenges Of the Strategies Of Nps As Ddss In Osccmentioning

confidence: 99%

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Nanoparticles as drug delivery systems in the treatment of oral squamous cell carcinoma: current status and recent progression

2023

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Oral squamous cell carcinoma (OSCC) is a common human malignancy with an estimated incidence of around 377,713 new cases worldwide in 2020. Despite the advance in clinical management, some of OSCC patients still miss the opportunity of completable resection of tumor, and have to accept medical therapies, e.g., chemotherapy, radiotherapy, or immunotherapy when the disease develops into the advanced stage. However, these therapies have been reported to be far from ideal due to the low efficiency of conventional delivery approaches. To obtain a better therapeutic effect, considerable attempts have been made toward to develop an effective drug delivery system (DDS). Nanoparticles (NPs) including inorganic NPs, polymer NPs, lipid NP, extracellular vesicles and cell membrane-based NPs have been evaluated as the better DDS candidates that can specifically accumulate in the tumor microenvironment along with a large amount of blood vessels. Emerging evidence suggested that NPs formulated with anticancer drugs including chemotherapeutic drugs, radiotherapy and immunotarget antibodies could remarkably improve the release and increase concentration of these drugs at the tumor site and show a better therapeutic efficacy, suggesting that NPs might serve as promising DDSs in the treatment of OSCC. Therefore, we have conducted this review to summarize recent progression and current status of diverse NPs as DDSs in this research field.

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Section: Different Nps As Ddss In Enhancing the Efficacy Of Anticance...mentioning

confidence: 99%

Section: Current Challenges Of the Strategies Of Nps As Ddss In Osccmentioning

confidence: 99%

Section: Current Challenges Of the Strategies Of Nps As Ddss In Osccmentioning

confidence: 99%

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Nanoparticles as drug delivery systems in the treatment of oral squamous cell carcinoma: current status and recent progression

2023

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“…It is reported that saliva peptide finger print technique employed nanotechnology for early detection of OSCC [50]. Lymphotropic nanoparticles are considered as novel class of MRI contrast agent that is also reported to have improved diagnostic examination sensitivity of OSCC [51]. Copper (64Cu) liposomes are reported to act as a radiotracer to augment visualization and detection of OSCC [52].…”

Section: Nanoparticles and Their Application In Oscc Diagnosis And Th...mentioning

confidence: 99%

Oral Squamous Cell Carcinoma and the Cutting Edge of Nanotechnology

Bharadwaj

Medhi

2020

Multidiscip Cancer Investig

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Introduction: Cancer is a group of diseases characterized by uncontrolled cellular growth or proliferation. Oral squamous cell carcinoma (OSCC) is a group of cancers mainly affecting the buccal cavity and associated area, with high rate of mortality and morbidity. Chronic consumption of alcohol, both smoking and smokeless tobacco, and betel quid are considered as the prominent determinants for the initiation and development of OSCC. The current treatment strategy of OSCC is associated with the common side effects of non-specific anticancer drug delivery. In addition, the treatment also deals with the recurrence of OSCC after completion of the therapy, which is responsible for its high mortality rate. Nanotechnology is an emerging discipline in drug delivery, disease diagnosis, and imaging. Nanoparticles are a group of colloidal carriers with approximately 1-1000 nm size range. Nanoparticles, due to large surface area to volume ratio, display different physicochemical characteristics favorable for their use in chemotherapy. The nanoparticles with options for modifications in theirsizes, surface charges, drug payload, and drug bioavailability can be used as a drug delivery system. The dynamic and flexible nature of nanoparticles can be employed to both active and passive targeting of cancer cells combating the usual side effects as well as other complexities associated with the conventional chemotherapy. Conclusions: The nanoparticles can be regarded as the future of drug delivery in cancer therapy.

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“…In particular, tobacco consumption, chronic alcohol abuse, and the human papillomavirus (HPV) are among the risk factors for developing OSCC [1]. Although new technologies are being implemented for the management of OSCC [2,3], the first-line treatment for this tumor entity remains, primarily, surgery, with or without chemoradiotherapy [4]. In addition to tumor resection, treatment could include neck dissection to remove the draining lymphovascular structures [5].…”

Section: Introductionmentioning

confidence: 99%

Postoperative Delirium in Patients with Oral Cancer: Is Intraoperative Fluid Administration a Neglected Risk Factor?

Obermeier

Kraus

Smolka

et al. 2022

Cancers

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Squamous cell carcinoma (SCC) is a malignant tumor derived from squamous cells and can be found in different localizations. In the oral cavity especially, it represents the most common type of malignant tumor. First-line therapy for oral squamous cell carcinoma (OSCC) is surgery, including tumor resection, neck dissection, and maybe reconstruction. Although perioperative mortality is low, complications such as delirium are very common, and may have long-lasting consequences on the patient’s quality of life. This study examines if excessive fluid administration, among other parameters, is an aggravating factor for the development of postoperative delirium. A total of 198 patients were divided into groups concerning the reconstruction technique used: group A for primary wound closure or reconstruction with a local flap, and group B for microsurgical reconstruction. The patients with and without delirium in both groups were compared regarding intraoperative fluid administration, fluid balance, and other parameters, such as blood loss, duration of surgery and overall ventilation, alcohol consumption, and creatinine, albumin, natrium, and hematocrit levels. The logistic regression for group A shows that fluid intake (p = 0.02, OR = 5.27, 95% CI 1.27–21.8) and albumin levels (p = 0.036, OR = 0.22, CI 0.054–0.908) are independent predictors for the development of delirium. For group B, gender (p = 0.026, OR = 0.34, CI 0.133–0.879) with a protective effect for females, fluid intake (p = 0.003, OR = 3.975, CI 1.606–9.839), and duration of ventilation (p = 0.025, OR = 1.178, CI 1.021–1.359) are also independent predictors for delirium. An intake of more than 3000 mL for group A, and 4150 mL for group B, increases the risk of delirium by approximately five and four times, respectively. Fluid management should be considered carefully in patients with OSCC, in order to reduce the occurrence of postoperative delirium. Different factors may become significant for the development of delirium regarding different surgical procedures.

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Nanotechnology in Oral Cavity Carcinoma: Recent Trends and Treatment Opportunities

Cited by 11 publications

References 69 publications

Nanoparticles as drug delivery systems in the treatment of oral squamous cell carcinoma: current status and recent progression

Nanoparticles as drug delivery systems in the treatment of oral squamous cell carcinoma: current status and recent progression

Oral Squamous Cell Carcinoma and the Cutting Edge of Nanotechnology

Postoperative Delirium in Patients with Oral Cancer: Is Intraoperative Fluid Administration a Neglected Risk Factor?

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