2015
DOI: 10.1002/ptr.5516
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Nanotechnology in Phytotherapy: Antiinflammatory Effect of a Nanostructured Thymol Gel from Lippia sidoides in Acute Periodontitis in Rats

Abstract: Lippia sidoides Cham (Verbenaceae) is largely distributed in the northeastern region of Brazil. It is popularly known as 'Alecrim-pimenta'. Recent studies have shown that some species of Lippia have interesting pharmacological activities. This study aimed to evaluate the effect of a nanostructured thymol gel (TG) 1.2 mg/g on acute phase of ligature-induced periodontitis model [acute periodontal disease (APD)] in rats. APD was induced in 24 Wistar rats subjected to ligature placement on left molars in maxillae.… Show more

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Cited by 41 publications
(26 citation statements)
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“…Thus, thymol could be used topically for the ablation of mast cell-associated skin inflammation disorders (Wechsler et al, 2014). In addition, the anti-inflammatory effect of a thymol gel from Lippia sidoides was evidenced in acute periodontitis in rats (Botelho et al, 2016).…”
Section: Fachinimentioning
confidence: 99%
“…Thus, thymol could be used topically for the ablation of mast cell-associated skin inflammation disorders (Wechsler et al, 2014). In addition, the anti-inflammatory effect of a thymol gel from Lippia sidoides was evidenced in acute periodontitis in rats (Botelho et al, 2016).…”
Section: Fachinimentioning
confidence: 99%
“…The use of plant extracts appears as a safe and effective alternative in this context. Medicinal plants present wound healing properties due to their vast variety of different constituents such as alkaloids, essential oils, flavonoids, among others, making them an important target for use in clinical practice (Bahramsoltani et al, ; Botelho et al , , b; Botelho et al ., ). The native tree of Copaifera , popularly known as Copaiba, has been widely used by natives from Latin America for centuries as a healing agent.…”
Section: Introductionmentioning
confidence: 97%
“…For instance, a positive control group was not included. Recently, using a non‐steroidal anti‐inflammatory drug (NSAID) as a positive control, a similar anti‐inflammation effect of thymol nanogel and diethylammonium diclofenac gel in acute periodontitis in rats was observed 38 . Therefore, a potential area of future research would be using an NSAID as a positive control for testing the anti‐inflammatory effect of carvacrol.…”
Section: Discussionmentioning
confidence: 99%