Nanotechnology in Urology

Jayasimha, Sudhindra

doi:10.4103/0970-1591.194780

Cited by 5 publications

(5 citation statements)

References 48 publications

(49 reference statements)

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“…In this context, nanotechnology has been envisaged as a great opportunity to improve both diagnostic and therapeutic approaches for bladder diseases. In fact, nanoconstructs are able to cross the urothelial barrier due to their small size approaching the molecular scale, may be functionalized for active targeting, can be visualized by different imaging techniques based on their physico-chemical features, and may be loaded with therapeutic agents, thus ensuring sustained release at the target site [ 12 , 13 , 14 , 15 , 16 , 17 , 18 ]. Nanoparticles (NPs) have also been explored as diagnostic tools to quantify analytes in urinary samples [ 19 ] and have been used for regenerative medicine and tissue engineering to enhance bladder repair/reconstruction and functional recovery [ 20 ].…”

Section: Nanotechnology and Urinary Bladder Imagingmentioning

confidence: 99%

Nanoparticle-Based Techniques for Bladder Cancer Imaging: A Review

Boschi

Malatesta

2023

IJMS

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Bladder cancer is very common in humans and is often characterized by recurrences, compromising the patient’s quality of life with a substantial social and economic impact. Both the diagnosis and treatment of bladder cancer are problematic due to the exceptionally impermeable barrier formed by the urothelium lining the bladder; this hinders the penetration of molecules via intravesical instillation while making it difficult to precisely label the tumor tissue for surgical resection or pharmacologic treatment. Nanotechnology has been envisaged as an opportunity to improve both the diagnostic and therapeutic approaches for bladder cancer since the nanoconstructs can cross the urothelial barrier and may be functionalized for active targeting, loaded with therapeutic agents, and visualized by different imaging techniques. In this article, we offer a selection of recent experimental applications of nanoparticle-based imaging techniques, with the aim of providing an easy and rapid technical guide for the development of nanoconstructs to specifically detect bladder cancer cells. Most of these applications are based on the well-established fluorescence imaging and magnetic resonance imaging currently used in the medical field and gave positive results on bladder cancer models in vivo, thus opening promising perspectives for the translation of preclinical results to the clinical practice.

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Section: Nanotechnology and Urinary Bladder Imagingmentioning

confidence: 99%

Nanoparticle-Based Techniques for Bladder Cancer Imaging: A Review

Boschi

Malatesta

2023

IJMS

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“…65 In addition, the EnSeal TM nanotechnology system (Ethicon Endo-Surgery Inc., Cincinnati, OH, USA) has been seen to reduce the drawbacks of diathermy during laparoscopic surgery, through creating haemostasis at lower temperatures, acting to reduce damage to underlying structures. 66 Finally, nanotechnology has further enhanced MRI scanning by being able to extravasate into the interstitium of tumours, which can then be highlighted on subsequent imaging scans, increasing the sensitivity and specificity of carcinoma identification. 67 It is hoped that these advances will become common practice in later years.…”

Section: A New Agementioning

confidence: 99%

Urological technology: where will we be in 20 years’ time?

Bernstein

2018

Therapeutic Advances in Urology

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Since prehistoric times, our understanding of urology has rapidly expanded. Whilst primitive urologists began by using urine as a therapeutic substance, modern urologists may find themselves removing a kidney remotely by driving a robotic arm, with seven degrees of movement, while using image overlay-augmented reality. This review provides an insight into the potential status of urological technology in 20 years' time, assessed through an analysis of developments in imaging, diagnostics, robotics and further technologies. A particular emphasis is given to the promising fields of minimally invasive techniques, nanotechnology and tissue engineering, which likely hold the key to a new era for urology.

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“…The need for an intravesical injections can be circumvented as the ef icacy remains the same which was demonstrated in acetic acid rat-model. Imaging of interstitial cystitis is also aided by nano-technology as liposomes and luorescent nano-particles bind to bladder lesions of interstitial cystitis which may be assessed by NIR-imaging of bladder" [45].…”

Section: Treatment Of Overactive Bladder/interstitial Cystitismentioning

confidence: 99%

Receptor pharmacology and other relevant factors in lower urinary tract pathology under a functional and toxicological approach: Instrument to better manage antimicrobials therapy

Luisetto¹

2018

Arch Pathol Clin Res

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In various patients conditions involved in lower urinary tract disease LUT (like overactive bladder, bladder neck sclerosis, dis-synergy (with our synenrgic contraction between bladder detrusor and bladder neck, BPH, recurrent cysytitis, interstitial cystitis, chronic prostatitis, uretral stenosys, loss of sfi nteric coordination. Prostatic cancer, anatomic abnormalities and other the receptor status play relevant role to reduce effect of vicious clycle that can be responsible in progression of the pathologic process. In this work the complex receptorial status is analyzed to verify new therapeutic strategies. Starting from the observation that various irritant substanties produce irritant stimulus in Prostatic Patients or in bladder neck condition is interesting to deep understand the etiopatogenesys and Functional results. In Various prostatic, bladder neck or ureteral condition a reduced urinary fl uss can produce infectious. Conditions like acute or chronic prostatitis. Irritants sustanties in diet (in example etilic alcohol drink, hot spices, crud meats, carbonate drinks, caffeine and other) can produce Painful stimulus in innervations of vecical trigonous, bladder neck and prostatic urethra. The same recurrent cystitis and Bph contribute in a complex situation. This stimulus produce ipertonus of bladder muscle involved in the expulsion of urine.

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Nanotechnology in Urology

Cited by 5 publications

References 48 publications

Nanoparticle-Based Techniques for Bladder Cancer Imaging: A Review

Nanoparticle-Based Techniques for Bladder Cancer Imaging: A Review

Urological technology: where will we be in 20 years’ time?

Receptor pharmacology and other relevant factors in lower urinary tract pathology under a functional and toxicological approach: Instrument to better manage antimicrobials therapy

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