Recent decades have witnessed the transformative impact of nanotechnology across various technology and industry sectors, ushering in significant improvements and, in some cases, revolutionary changes. Nanotechnology integrates progress achieved in chemistry, physics, materials science, and biotechnology to craft innovative materials with distinctive properties attributable to their structuring at the nanometer scale. Sectors such as information technology, energy, environmental science, and transportation are all benefiting from nano-technological advancements. The study investigated Spirulina-mediated titanium dioxide nanoparticle’s effects on silkworm economic traits. Characterization revealed uniform nanoparticles with a size of 97 nm. Silkworms fed with 50 ppm concentration showed improved weight, cocoon traits, silk quality, and reduced renditta. This suggests the potential benefits of nanoparticletreated mulberry leaves in sericulture.