Nanotechnology solutions to restore antibiotic activity

Abstract

This review focuses on the development of nanoparticle systems that enables to enhance and restore the antibiotic activity for drug-resistant organisms. New and more aggressive antibiotic resistant bacteria and parasites calls for the development of new therapeutic strategies to overcome the inefficiency of conventional antibiotics and bypass treatment limitations related to these pathologies. Nanostructured biomaterials, nanoparticles in particular, have unique physicochemical properties such as ultra-small and controllable size, large surface area to mass ratio, high reactivity, and functionalizable structure. These properties can be applied to facilitate the administration of antimicrobial drugs, thereby overcoming some of the limitations in traditional antimicrobial therapeutics. Here the current progress and challenges in synthesizing nanoparticle platforms for restoring activity of various antimicrobial drugs are reviewed with an emphasis on antibiotics. We also call attention to the need to unite the shared interest between nanoengineers and microbiologists in developing nanotechnology for the treatment of microbial diseases.

Lipid oligonucleotides as a new strategy for tackling the antibiotic resistance

“…They represent a major therapeutic medical tool, which can be used in many treatments, including infections, chemotherapies, transplantation, and surgery for example. However, antimicrobial resistance (AMR) has been observed at dangerously high levels worldwide [2][3][4][5][6][7] , alternative therapeutic strategies are urgently needed 8 . Among the different resistance phenomena, the AMR involving the third-generation cephalosporins (3GCs), represent one of the major class of antibiotic used worldwide, has become a major public health issue [9][10][11] .…”

Nanomedicines for the Delivery of Antimicrobial Peptides (AMPs)

“…Out of the available 71,102 papers indexed in the Web of Science, a total of 70,948 combining AMPs with nanoparticles or nanomaterials have been published over the last 20 years in a range of disciplines ( Figure 1). Evidence collected in the review work of Huh and Kwon [1], Pelgrift and Friedman [3], Brooks and Brooks [2], Diab et al [32] and Shimanovich and Gedanken [33] clarifies microbial drug resistance mechanisms and how nanotechnology may be considered a tool against this issue. Development of drug resistance occurs in (at least) three steps: (i) acquisition by microbes of resistance genes; (ii) expression of those resistance genes; (iii) selection for microbes expressing those resistance genes.…”

Sonochemical Formation of Copper/Iron‐Modified Graphene Oxide Nanocomposites for Ketorolac Delivery

“…Immobilization with drug molecules can regulate GO dispersal in watero ri nt he cell culture media, reduce cell/tissue toxicity,a nd induce accumulationi n targetc ells andt issues. [62][63][64][65] Drug release from GO can be activated by the pH gradientn aturallyp resent in cells/tissues through the distortion of interactions between the drug and GO nanocomposite. [53] Sonochemistry is an efficient toolt oc onstruct multifarious molecular carriers for resourceful drug delivery, [66] and it is derived from acoustic cavitation, which is the formation,g rowth, and implosive collapse of gaseous bubbles, acting as highly energetic hot spots.…”