Nanotheranostic Application of Fluorescent Protein-Gold Nanocluster Hybrid Materials: A Mini-review

Ding, Han; Chen, Zhijun

doi:10.7150/ntno.58060

Cited by 9 publications

(4 citation statements)

References 107 publications

(139 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Under the detection of TEM, particles that were 5~6 nm in size were observed (Figure 3a). The average size of the particles, as shown on the TEM images, was larger than those previously reported [2,26], although a similar size (6.3 nm) of Au NCs has also been reported, using BSA as capping ligands [27]. To verify that the images of the particles shown on the TEM are Au NCs, not the smaller size of Ag NPs, EDS was employed to determine the components of the particles.…”

Section: Synthesis Of Gold Nanoclusters Using Gssg As Capping Ligandssupporting

confidence: 50%

Silver Nanoparticle-Mediated Synthesis of Fluorescent Thiolated Gold Nanoclusters

et al. 2021

View full text Add to dashboard Cite

A new strategy using silver nanoparticles (Ag NPs) to synthesize thiolated Au NCs is demonstrated. The quasi-spherical Ag NPs serve as a platform, functioning as a reducing agent for Au (III) and attracting capping ligands to the surface of the Ag NPs. Glutathione disulfide (GSSG) and dithiothreitol (DTT) were used as capping ligands to synthesize thiolated Au NCs (glutathione-Au NCs and DTT-Au NCs). The glutathione-Au NCs and DTT-Au NCs showed red color luminance with similar emission wavelengths (630 nm) at an excitation wavelength of 354 nm. The quantum yields of the glutathione-Au NCs and DTT-Au NCs were measured to be 7.3% and 7.0%, respectively. An electrophoretic mobility assay showed that the glutathione-Au NCs moved toward the anode, while the DTT-Au NCs were not mobile under the electric field, suggesting that the total net charge of the thiolated Au NCs is determined by the charges on the capping ligands. The detection of the KSV values, 26 M−1 and 0 M−1, respectively, revealed that glutathione-Au NCs are much more accessible to an aqueous environment than DTT-Au NCs.

show abstract

Section: Synthesis Of Gold Nanoclusters Using Gssg As Capping Ligandssupporting

confidence: 50%

Silver Nanoparticle-Mediated Synthesis of Fluorescent Thiolated Gold Nanoclusters

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Gold nanoclusters have diameters smaller than 2 nm, and corresponding number of atoms typically less than 100. Presently, it is possible to experimentally synthesize metal nanoparticles with diameters down to 1 nm [29,30]. On the other side, the simulations of gold nanoclusters in water under realistic conditions are scarce in the literature, with the exception of a few studies [16,17].…”

Section: Introductionmentioning

confidence: 99%

Size-dependent effects of the thermal transport at gold nanoparticle–water interfaces

Gutiérrez-Varela

Mérabia

Santamaría

2022

The Journal of Chemical Physics

View full text Add to dashboard Cite

The transfer of heat from a plasmonic nanoparticle to its water environment has numerous applications in the ﬁelds of solar energy conversion and photothermal therapies. We use non-equilibrium molecular dynamics to investigate the size-dependent eﬀects of the interfacial thermal conductance of gold nanoparticles immersed in water and of tunable wettability. The interfacial thermal conductance is found to increase when the nanoparticle size decreases. We rationalize such a behavior with a generalized acoustic model, where the interfacial bonding decreases with the nanoparticle size. The analysis of the interfacial thermal spectrum reveals the importance of the low frequency peak of the nanoparticle spectrum as it matches relatively well the oxygen peak in the vibrational spectrum. However, by reducing the nanoparticle size, the low frequency peak is exacerbated, explaining the enhanced heat transfer observed for small nanoparticles. Finally, we assess the accuracy of continuum heat transferequations to describe the thermal relaxation of small nanoparticles with initial high temperatures.We show that, before the nanoparticle looses its integrity, the continuum model succeed in describing with small percentage deviations the molecular-dynamics data. This work brings a simple methodology to understand, beyond the plasmonic nanoparticles, thermal boundary conductance between a nanopartice and its environment.

show abstract

“…In our previous study, we designed a protein‐gold hybrid material with red fluorescence (PGHM‐R), which is constructed from bovine serum albumin (BSA), gold nanoclusters, and amino acids. [ 23–25 ] Notably, we found that the as‐prepared PGHM‐R can not only efficiently load with drugs (DOX), [ 26 ] genes (pGal‐sGFP), [ 27 ] and Fe 2+ , but also accumulated at tumor sites with high efficiency. [ 25 ] Herein, we exploited as‐prepared PGHM‐R as both a Fe 2+ stabilizer and a carrier and developed a safe and efficient ferroptosis inducer PGHM‐R‐Fe for inducing ferroptosis in hepatoma cells ( Scheme ).…”

Section: Introductionmentioning

confidence: 99%

Protein‐Gold Nanoclusters Loaded with Ferrous Ions for Inducing Ferroptosis of Hepatoma Cells

Jiang

Liu

et al. 2023

Adv Materials Technologies

Self Cite

View full text Add to dashboard Cite

Ferroptosis driven by the iron-dependent accumulation of lipid peroxides and subsequent oxidative damage of biological membranes has shown great potential in the treatment of various diseases, especially cancer. However, suffering from the lack of safe and efficient delivery strategies for the unstable ferrous ions (Fe 2+ ), the therapeutic efficacy induced by ferroptosis is always unsatisfactory. Herein, a protein-based nanocomposite (Protein-Gold Hybrid Materials-Red, PGHM-R) is designed as both an Fe 2+ stabilizer and a carrier for the safe and efficient delivery of Fe 2+ to hepatoma cells. The conspicuous feature of ferroptosis, such as downregulation of GPX4 and FTH1, upregulation of ASCL4 and NOX1, as well as mitochondrial deformation, is observed in PGHM-R-Fe-treated hepatoma cells, which demonstrate that PGHM-R-Fe can effectively trigger ferroptosis of hepatoma cells. More importantly, systematic in vivo therapeutic outcomes demonstrate the low side effects and the high tumor-inhibiting ratio of 58% of PGHM-R-Fe in the tumor model of hepatocellular carcinoma-bearing mice. This novel strategy for inducing the ferroptosis of cancer cells based on utilizing protein to deliver Fe 2+ holds great potential in the clinical applications of ferroptosis-based therapy.

show abstract

Nanotheranostic Application of Fluorescent Protein-Gold Nanocluster Hybrid Materials: A Mini-review

Cited by 9 publications

References 107 publications

Silver Nanoparticle-Mediated Synthesis of Fluorescent Thiolated Gold Nanoclusters

Silver Nanoparticle-Mediated Synthesis of Fluorescent Thiolated Gold Nanoclusters

Size-dependent effects of the thermal transport at gold nanoparticle–water interfaces

Protein‐Gold Nanoclusters Loaded with Ferrous Ions for Inducing Ferroptosis of Hepatoma Cells

Contact Info

Product

Resources

About