Nanotherapeutics of Phytoantioxidants in Cancer

Shah, Ashish S.; Patel, Vaishali; Parmar, Ghanshyam

doi:10.1002/9781119811794.ch22

Cited by 2 publications

(3 citation statements)

References 116 publications

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“…According to an organism's cell population, the Mechanism of tubulin is shown in Figure 1 that how tubulin is polymerized and depolymerized. A popular antitumor technique is to interfere with Micro tubulin kinetics, and several medications that use this method are clinically efficient against a variety of tumors [15][16][17] .…”

Section: Tub (Tubulin Alpha-beta Dimer Electron Diffraction)mentioning

confidence: 99%

“…A database of naturally occurring chemicals generated from plants with anti-cancerous properties is called NPACT. It has 1574 records, each of which includes details on the compound's structure, physical, elemental, and topological characteristics, cancer kind, cell lines, inhibition levels (The IC 50 , ED 50 , EC 50 , GI 50 ), biological targets, commercial providers, and resemblance 1,2 . A gland in men's bodies located just in front of the rectum and underneath the bladder…”

Section: Introductionmentioning

confidence: 99%

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<i>In Silico</i> Screening of Phytochemicals as an Approach against Tubulin Inhibitor in Prostate Cancer

Shaikh,

Patel,

Sharma

et al. 2024

JNR

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Background: Millions of men worldwide are affected by the complicated disease of prostate cancer, which is most common in areas with high socioeconomic indices. There is growing proof indicating that not all cases of prostate tumors are the same as well as that monitoring techniques and prostate-specific localization therapies are harmless methods of dealing with this mild illness. Plant-based chemicals are believed to be an important reservoir of novel bioactive compounds with a range of different chemical motifs. Aim: The potential of tubulin-targeting medications to target Micro tubulin mechanisms and disrupt important cellular processes which include mitosis, cell signalling, cytoplasmic trafficking and angiogenesis is what makes them such effective cancer therapies. Methods: The current research uses a variety of applications for emphasizing the drug-like properties, toxicology testing, and in silico analysis of numerous phytochemicals in prostate cancer by using the NPACT (Naturally occurring plant-based anti-cancer compound) data bank, Auto dock, Biovia discovery studio for the preparation of target protein and interaction between targeted protein site and Phytocompounds. Result and Conclusion: outcomes of the in silico screening, such as the discovery of possible bioactive substances or interested targets. The nine phytochemicals exhibited the greatest docking results, proving they are potent inhibitors of prostate tumors. To verify the computational results, compare the in silico assumptions with empirical information or previously published literature. To reinforce the conclusions, illustrations such as modifications to conformation, binding ways, or sequences of interactions. This in silico study is a critical first step in realizing the enormous promise of plant-based constituents in the field of drugs.

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Section: Tub (Tubulin Alpha-beta Dimer Electron Diffraction)mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

<i>In Silico</i> Screening of Phytochemicals as an Approach against Tubulin Inhibitor in Prostate Cancer

Shaikh,

Patel,

Sharma

et al. 2024

JNR

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“…Ayurveda was able to establish that the various parts of mango tree have varied medicinal properties. Parts of the tree are rich in mangiferin, a polyphenolic antioxidant and have served as, anti-lipid peroxidation agent, immunomodulatior, cardiotonic, hypotensive, wound healing agent [6].…”

Section: Introductionmentioning

confidence: 99%

Anti-Hyperlipidemic Effect of Methanol Seed Kernel Extract of Mangifera indica on Wistar Rat Model

Uchenna

Obioma

Chinedu

et al. 2023

AJBGMB

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The aim of this study was to evaluate the anti-hyperlipidemic effect of methanol Mangifera indica seed kernel extract on hyperlipidemic Wistar rats. Mango seed kernels were dried at room temperature before being ground into fine powder. 500 g of mango seed kernel powder was soaked in 500 mL of 98 % methanol and shaken intermittently for 72 h, after which the extract was concentrated. Twenty five adult male wistar rats were divided into five groups of five rats each. Group I: was administered 2 ml of distilled water. Groups II-V were induced hyperlipidemia. However, while Group II was not treated with the extract (negative control), Groups III and IV were treated with 150 and 350 mg/kg body weight of mango seed kernel extract (MSKE) and Group V was administered the standard drug (atorvastatin). Treatment lasted for 21 days, after which rats were sacrificed and blood sample was collected and subsequently analyzed via standard procedures. Hyperlipidemia was characterized by increased levels of total cholesterol and Low Density Lipoprotein (LDL). Oral administration of MSKE significantly (P<0.05) reduced the aforementioned indices to levels which though were significantly (P<0.05) higher than that reported for the normal control group. On the other hand, it was observed that that the levels of high density lipoprotein (HDL) and triacylglyceride (TG) in the negative control (Group II) were significantly (P<0.05) low but increased following oral administration of extract in a dose dependent manner. It was also observed that MSKE of M. indica reduced the body weight of hyperlipidemic rats. In conclusion, it can be deduced from this study that MSKE has the potential to address hyperlipidemia

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Nanotherapeutics of Phytoantioxidants in Cancer

Cited by 2 publications

References 116 publications

<i>In Silico</i> Screening of Phytochemicals as an Approach against Tubulin Inhibitor in Prostate Cancer

<i>In Silico</i> Screening of Phytochemicals as an Approach against Tubulin Inhibitor in Prostate Cancer

Anti-Hyperlipidemic Effect of Methanol Seed Kernel Extract of Mangifera indica on Wistar Rat Model

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