Nanotopography and Plasma Treatment: Redesigning the Surface for Vascular Graft Endothelialisation

Chong, Debra; Gadegaard, Nikolaj; Seifalian, AM; Dalby, M.J.; Hamilton, George

doi:10.1016/j.ejvs.2014.06.029

Cited by 5 publications

(6 citation statements)

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“…Plasma treatment can introduce hydroxyl and carbonyl groups that increase hydrophilicity of the scaffold and increase cell adhesion. 91 The argon plasma ablation of polyethylene led to oxidation and increased surface roughness which had positive effect on fibroblasts cells. 92 An optimal scaffold mimics the basic structure of the ECM.…”

Section: Surface Modificationmentioning

confidence: 99%

Tubular organ epithelialisation

et al. 2016

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Hollow, tubular organs including oesophagus, trachea, stomach, intestine, bladder and urethra may require repair or replacement due to disease. Current treatment is considered an unmet clinical need, and tissue engineering strategies aim to overcome these by fabricating synthetic constructs as tissue replacements. Smart, functionalised synthetic materials can act as a scaffold base of an organ and multiple cell types, including stem cells can be used to repopulate these scaffolds to replace or repair the damaged or diseased organs. Epithelial cells have not yet completely shown to have efficacious cell–scaffold interactions or good functionality in artificial organs, thus limiting the success of tissue-engineered grafts. Epithelial cells play an essential part of respective organs to maintain their function. Without successful epithelialisation, hollow organs are liable to stenosis, collapse, extensive fibrosis and infection that limit patency. It is clear that the source of cells and physicochemical properties of scaffolds determine the successful epithelialisation. This article presents a review of tissue engineering studies on oesophagus, trachea, stomach, small intestine, bladder and urethral constructs conducted to actualise epithelialised grafts.

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Section: Surface Modificationmentioning

confidence: 99%

Tubular organ epithelialisation

et al. 2016

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“…The ePTFE scaffold was changed as graft material because of leeching of possible carcinogenic material and substituted with a polyurethane urea graft, coated with a new diazeniumdiolate dispersed within the matrix. After 21 days, all control grafts were occluded but the NO coating grafts were patent (10).…”

Section: Resultsmentioning

confidence: 99%

Drug eluting grafts for hemodialysis access

Glickman

2017

J Vasc Access

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The development of new methods for drug elution of graft material, biofiber films and resurfacing of prosthetic graft surfaces offers new opportunities for improvement of graft function in arteriovenous (AV) access. Three areas of research include developing grafts that reduce the development of neointimal hyperplasia, reducing infection and reducing thrombogenicity. The only drug eluting graft presently being used, is the heparin coated expanded polytetrafluoroethylene (ePTFE) graft, which has been shown to decrease the incidence of early thrombosis. New drug eluting grafts include those with paclitaxel and those with antibiotics. The development of a hybrid coated prosthetic graft that can deliver targeted gene therapies holds great promise in the field.

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“…In addition, the surface of deposited film was charged during the plasma discharge and this charging affected the formation of the peaks on the surface. The effects of plasma on the nanotopography of surfaces have been recently noticed and investigated more and more …”

Section: Resultsmentioning

confidence: 99%

Synthesis of Fluorene‐Type Thin Film Under Biphenyl/Methane Plasma Environment

Mansuroglu

Manolache

2015

Plasma Processes & Polymers

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Fluorene‐type (C13H10) thin films were synthesized by using the mixture of biphenyl (C12H10) and methane (CH4) plasma. The reactor is a parallel plate installation; upper electrode is connected to 13.56 MHz rf power and lower electrode is grounded. The thin films were deposited by applying a negative bias potential between the substrate and the wall of reactor. The films were investigated by residual gas analysis (RGA), UV–vis spectroscopy, atomic force microscope (AFM) and ellipsometry. They had significant nanostructured properties which were suitable for photovoltaic applications. The conjugation was improved by iodine doping and the optical band gap energy dropped down up to 2.85 eV.

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Nanotopography and Plasma Treatment: Redesigning the Surface for Vascular Graft Endothelialisation

Cited by 5 publications

References 0 publications

Tubular organ epithelialisation

Tubular organ epithelialisation

Drug eluting grafts for hemodialysis access

Synthesis of Fluorene‐Type Thin Film Under Biphenyl/Methane Plasma Environment

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