Nanotoxicology: An Integrative Environmental Challenge

Abstract

A contemporary and expanding area of toxicology research is nanotoxicology. It focuses on evaluating the toxicological characteristics of nanoparticles (NPs) in order to determine whether and how much of a risk they pose to society or the environment. Fundamental characteristics of nanoparticles (consisting of shape, size, surface charge, surface area, solubility/dissolution, coating, and crystal structure), in addition to coincidental aspects (like climate, pH, salinity, ionic potency, and organic material), generally impact NP attitude, circumstance, and movement, and basically toxicity. The processes underpinning nanomaterials' (NMs) toxicity have recently been intensively researched. One such mechanism is the toxicity of reactive oxygen species (ROS). Excessive production of ROS causes oxidative stress, which causes cells to lose their capacity to sustain normal redox-regulated processes. This review consists of details referring to the physical and chemical characteristics of nanomaterials and their properties for convenient toxicological assessment, disclosure, and coincidental transport, fate, and genotoxic effects.

Enhancement of Oncology Nurses' Competency Regarding Management of Intravenous Chemotherapy Extravasation

“…Extravasation may result in severe ulcer and necrosis of the thorax, ligaments, subcutaneous tissue, skin, and peripheral vascular system .It may lead to life-threatening problems as lifelong deformity, permanent functional limitations, amputation of the affected extremity and significantly influence patient' quality of life (Haynes, & Ortega-Loayza, 2020). The incidence of extravasation ranges from 0.01% to 7% through peripheral venous access and from 0.26% to 4.7% through a central venous access ( Hassan, & Hasary, 2022).…”