Nanotoxicology

Simón‐Vázquez, Rosana; Peleteiro, Mercedes; Lozano, Tamara; González-Fernández, África

doi:10.1016/b978-0-12-415769-9.00015-7

Nanobiotechnology - Inorganic Nanoparticles vs Organic Nanoparticles

2012

DOI: 10.1016/b978-0-12-415769-9.00015-7

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Nanotoxicology

Rosana Simón‐Vázquez

Mercedes Peleteiro

Tamara Lozano

et al.

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Cited by 2 publications

(2 citation statements)

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“…higher uptake than those with negative charge. This could be 589 explained if we considered that the uptake is assisted by the elec-590 trostatic interaction between the positively charged nanoparticles 591 and the negatively charged cell membranes [38] and also by the 592 inherent penetration properties of protamine [39]. Fig.…”

mentioning

confidence: 98%

“…Keywords : 29 Nanoparticles 30 Antigen delivery 31 Protamine 32 Vaccine 33 Hyaluronic acid 34 Hepatitis B 35 3 6 a b s t r a c t 37 The use of biodegradable nanoparticles as antigen delivery vehicles is an attractive approach to overcome 38 the problems associated with the use of Alum-based classical adjuvants. Herein we report, the design and 39 development of protamine-based nanoparticles as novel antigen delivery systems, using recombinant 40 hepatitis B surface antigen as a model viral antigen.…”

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confidence: 99%

See 1 more Smart Citation

Protamine-based nanoparticles as new antigen delivery systems

González-Aramúndiz

Olmedo

González-Fernández

et al. 2015

European Journal of Pharmaceutics and Biopharmaceutics

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mentioning

confidence: 98%

mentioning

confidence: 99%

Protamine-based nanoparticles as new antigen delivery systems

González-Aramúndiz

Olmedo

González-Fernández

et al. 2015

European Journal of Pharmaceutics and Biopharmaceutics

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Stage-specific exposure of Caenorhabditis elegans to cadmium identifies unique transcriptomic response cascades and an uncharacterized cadmium responsive transcript

Almutairi,

Khan,

Harrison-Smith

et al. 2024

Metallomics

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Age/stage sensitivity is considered a significant factor in toxicity assessments. Previous studies investigated cadmium (Cd) toxicosis in Caenorhabditis elegans, and a plethora of metal-responsive genes/proteins have been identified and characterised in fine detail; however, most of these studies neglected age sensitivity and stage-specific response to toxicants at the molecular level. This present study compared the transcriptome response between C. elegans L3 vs L4 larvae exposed to 20 µM Cd to explore the transcriptional hallmarks of stage sensitivity. The results showed that the transcriptome of the L3 stage, despite being exposed to Cd for a shorter period, was more affected than the L4 stage, as demonstrated by differences in transcriptional changes and magnitude of induction. Additionally, T08G5.1, a hitherto uncharacterised gene located upstream of metallothionein (mtl-2), was transcriptionally hyperresponsive to Cd exposure. Deletion of one or both metallothioneins (mtl-1 and/or mtl-2) increased T08G5.1 expression, suggesting that its expression is linked to the loss of metallothionein. The generation of an extrachromosomal transgene (PT08G5.1:: GFP) revealed that T08G5.1 is constitutively expressed in the head neurons and induced in gut cells upon Cd exposure, not unlike mtl-1 and mtl-2. The low abundance of cysteine residues in T08G5.1 suggests, however, that it may not be involved directly in Cd sequestration to limit its toxicity like metallothionein, but might be associated with a parallel pathway, possibly an oxidative stress response.

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Nanotoxicology

Cited by 2 publications

References 208 publications

Protamine-based nanoparticles as new antigen delivery systems

Protamine-based nanoparticles as new antigen delivery systems

Stage-specific exposure of Caenorhabditis elegans to cadmium identifies unique transcriptomic response cascades and an uncharacterized cadmium responsive transcript

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