Nanozyme Based on Porphyrinic Metal–Organic Framework for Electrocatalytic CO<sub>2</sub> Reduction

Lee, Junghye; Choi, Hansaem; Mun, Jinhong; Jin, Eunji; Lee, Soochan; Nam, Joohan; Umer, Muhammad; Cho, Jaeheung; Lee, Geunsik; Kwon, Young-Hyuk; Choe, Wonyoung

doi:10.1002/sstr.202200087

Cited by 6 publications

(6 citation statements)

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Section: Porphyrin-based Mofsmentioning

confidence: 99%

“…[16c] Nanozymes can be used with target analytemediated redox processes to achieve detection of target analytes through signal conversion, and are therefore widely used in biosensing. [68] Porphyrin-based nanozymes have been used to detect CO 2 , [28] bacteria, [45] glucose, [44,51] heparin, [32] and other biological indicators of disease substances. Porphyrins have been utilized as fluorescent detectors due to their strong light absorption.…”

Section: Biosensingmentioning

confidence: 99%

“…Pep/hemin [ 12a ] Hemin Nbrpm 6 , Nce 6 , Npyr POD Lignin depolymerization Ce6@MIL-100/HA [ 30] Chlorin e6 MIL-100, Hyaluronic acid POD Chemodynamic therapy and PDT Azo(Fe)PPOP [ 46] FeTPP(NO 2 ) 4 OAPS POD Detection of malathion PPF-100 [ 28] OETPP Cu paddle-wheel clusters POD Reduction of CO 2…”

Section: Conclusion and Future Prospectsmentioning

confidence: 99%

“…Nonplanar porphyrins are characterized by excellent catalytic activity, high stability, and adjustable axial binding strength. [ 28 ] A nonplanar porphyrin, 2,3,7,8,12,13,17,18‐(octaethyl)−5,10,15,20‐tetrakis(4‐carboxybiphenyl)porphyrin (OETPP), was used as the linker to synthesize a MOF nanozyme (PPF‐100) through the combination with Cu(NO 3 ) 2 ·2.5H 2 O ( Figure A). The nanozyme was formed by in situ metallization of OETPP and formation of a 2D mesh structure using Cu paddlewheel cluster as the building block (Figure 2B,C).…”

Section: Porphyrin‐based Nanozymesmentioning

confidence: 99%

“…C) Fourier and low-pass filtered version of the transmission electron microscopy (TEM) image of the PPF-100 nanozyme. D) AFM image (scale bar, 2 μm) of PPF-100 nanozyme.Reproduced with permission [28]. Copyright 2022, Wiley-VCH.…”

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confidence: 99%

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Porphyrin‐Based Nanozymes for Biomedical Applications

Cheng,

Li,

Zou

2024

Advanced Therapeutics

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Porphyrins are a class of heterocyclic compounds with a tetrapyrrole conjugated structure, having unique physical, chemical, and optical properties. They have garnered significant interest as building blocks for fabricating nanomaterials due to their attractive features. Porphyrins also serve as the catalytic activity centers for various biological enzymes, making them promising functional molecules for constructing artificial enzymes known as nanozymes. Despite this, the emerging field of porphyrin‐based nanozymes still lacks a comprehensive summary. Here, we aim to provide a comprehensive overview of porphyrin‐based nanozymes that have been engineered with varying methods and materials. Additionally, we highlight the latest researches on their biomedical applications, including cancer treatment, biosensing, antibacterial, and antioxidant applications. The focus lies in the supramolecular mechanisms underlying the nanoengineering approaches and catalytic functions of these nanozymes. The challenges and prospects of constructing porphyrin‐based nanozymes to promote their biomedical applications and the development of next‐generation nanomedicines are also discussed.This article is protected by copyright. All rights reserved

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Section: Porphyrin-based Mofsmentioning

confidence: 99%

Section: Biosensingmentioning

confidence: 99%

Section: Conclusion and Future Prospectsmentioning

confidence: 99%

Section: Porphyrin‐based Nanozymesmentioning

confidence: 99%

mentioning

confidence: 99%

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Porphyrin‐Based Nanozymes for Biomedical Applications

Cheng,

Li,

Zou

2024

Advanced Therapeutics

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Modulating the Hydrophilic‐Hydrophobic Microenvironment of MOF‐Stabilized Pt Nanozymes: the Role of H₂O in the Peroxidase‐Like Catalyzed Reaction

Shen,

Wu,

Guo

et al. 2024

Adv Funct Materials

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Hydrophilicity‐hydrophobicity modulation of active sites provides a promising strategy for enhancing catalytic performance. Current researches focus on the influence of substrate molecules, however, the role of H2O molecules is often overlooked in nanozyme‐catalyzed reactions. Herein, bioinspired Pt@ZIF‐R (R = ‐90, ‐8, ‐8@TMS, where TMS is tetraethoxysilane) nanozymes are designed as model catalysts, with Pt nanoparticles as active centers and metal organic‐framework nanocavities as hydrophilic‐hydrophobic binding pockets, revealing the critical role of H2O in the peroxidase‐like catalytic process of H2O2 decomposition. A positive correlation between catalytic activity and hydrophobicity is observed, and strong hydrophobic Pt@ZIF‐8@TMS nanozyme exhibits the best catalytic performance. Theoretical calculations indicate that as hydrophobicity increases, solvent H2O reduces the competitive adsorption with H2O2 and decreases the energy barrier of the rate‐determining step (2*O→*O2) simultaneously. In addition, the desorption of the product H2O is thermodynamically favorable with increasing hydrophobicity. Importantly, Pt@ZIF‐8@TMS nanozyme is successfully used to develop a colorimetric biosensor for the detection of organophosphorus pesticides, with a detection limit as low as 0.7 ng mL−1, which is superior to numerous existing methods. This work provides fundamental insights into the function of hydrophobicity in boosting catalytic activity, which may offer guidance for the development of efficient nanozymes.

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Recent strategies to improve the electroactivity of metal–organic frameworks for advanced electrocatalysis

Wei,

Liu,

Ibragimov

et al. 2024

Information & Functional Materials

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Metal–organic frameworks (MOFs) have emerged as promising materials in the realm of electrocatalysis due to their high surface area, tunable porosity, and versatile chemical functionality. However, their practical application has been hampered by inherent limitations such as low electrical conductivity and a limited number of active metal sites. Researchers addressed these challenges through various strategies, including enhancing conductivity by incorporating conductive materials and metal nanoparticles, modifying the structure and composition of MOFs by replacing metal nodes and functionalizing linkers, and preparing MOFs catalysts through thermal processes such as decarburization and conversion into metal oxides, phosphides (MPs), and sulfides (MSs). This review provided a comprehensive summary of the strategies that were employed to enhance the electroactivity of MOFs for improved electrocatalytic performance in recent years. It also explored future directions and potential innovations in the design and synthesis of MOF‐based electrocatalysts, offering valuable insights for advancing their application in sustainable energy technologies.

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Nanozyme Based on Porphyrinic Metal–Organic Framework for Electrocatalytic CO₂ Reduction

Cited by 6 publications

References 60 publications

Porphyrin‐Based Nanozymes for Biomedical Applications

Porphyrin‐Based Nanozymes for Biomedical Applications

Modulating the Hydrophilic‐Hydrophobic Microenvironment of MOF‐Stabilized Pt Nanozymes: the Role of H₂O in the Peroxidase‐Like Catalyzed Reaction

Recent strategies to improve the electroactivity of metal–organic frameworks for advanced electrocatalysis

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Nanozyme Based on Porphyrinic Metal–Organic Framework for Electrocatalytic CO2 Reduction

Cited by 6 publications

References 60 publications

Porphyrin‐Based Nanozymes for Biomedical Applications

Porphyrin‐Based Nanozymes for Biomedical Applications

Modulating the Hydrophilic‐Hydrophobic Microenvironment of MOF‐Stabilized Pt Nanozymes: the Role of H2O in the Peroxidase‐Like Catalyzed Reaction

Recent strategies to improve the electroactivity of metal–organic frameworks for advanced electrocatalysis

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Product

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Nanozyme Based on Porphyrinic Metal–Organic Framework for Electrocatalytic CO₂ Reduction

Modulating the Hydrophilic‐Hydrophobic Microenvironment of MOF‐Stabilized Pt Nanozymes: the Role of H₂O in the Peroxidase‐Like Catalyzed Reaction