Nanozyme’s catalytic activity at neutral pH: reaction substrates and application in sensing

Chen, Xueshan; Liao, Jing; Lin, Yao; Zhang, Jinyi; Zheng, Chengbin

doi:10.1007/s00216-023-04525-w

Cited by 15 publications

(10 citation statements)

References 120 publications

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“…Nanozymes can perform various enzyme-like functions in different areas, such as regulating biomolecular and cellular pathways, cleaving proteins or poly nucleic acids, modulating oxidative balance, and performing site-specific cleavage of prodrugs. , These functions make nanozymes useful in different applications, including therapeutics, regenerative medicine, diagnostics, and preservation. Endogenous enzymes in the cell catalyze metabolic events and produce hazardous ROS that potentially kills the bacterial cell membranes and intracellular components by oxidation .…”

Section: Nanozymesmentioning

confidence: 99%

Perspectives on Usage of Functional Nanomaterials in Antimicrobial Therapy for Antibiotic-Resistant Bacterial Infections

et al. 2023

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The clinical applications of nanotechnology are emerging as widely popular, particularly as a potential treatment approach for infectious diseases. Diseases associated with multiple drug-resistant organisms (MDROs) are a global concern of morbidity and mortality. The prevalence of infections caused by antibiotic-resistant bacterial strains has increased the urgency associated with researching and developing novel bactericidal medicines or unorthodox methods capable of combating antimicrobial resistance. Nanomaterial-based treatments are promising for treating severe bacterial infections because they bypass antibiotic resistance mechanisms. Nanomaterial-based approaches, especially those that do not rely on small-molecule antimicrobials, display potential since they can bypass drug-resistant bacteria systems. Nanoparticles (NPs) are small enough to pass through the cell membranes of pathogenic bacteria and interfere with essential molecular pathways. They can also target biofilms and eliminate infections that have proven difficult to treat. In this review, we described the antibacterial mechanisms of NPs against bacteria and the parameters involved in targeting established antibiotic resistance and biofilms. Finally, yet importantly, we talked about NPs and the various ways they can be utilized, including as delivery methods, intrinsic antimicrobials, or a mixture.

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Section: Nanozymesmentioning

confidence: 99%

Perspectives on Usage of Functional Nanomaterials in Antimicrobial Therapy for Antibiotic-Resistant Bacterial Infections

et al. 2023

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“…The operating conditions of the reaction, such as light, pH, and temperature, may influence the selectivity of the nanozymes. 124 For instance, upon light irradiation, these materials can undergo structural changes that expose or conceal the active sites of the nanozymes, leading to changes in activity, substrate, and analyte selectivity. Liu et al developed three photoactive MOF-based nanozymes (2D-TCPP, 3D-TCPP, and AD-TCPP) with different structures and unshielded active sites.…”

Section: Comprehensive Selectivity Improvementmentioning

confidence: 99%

A comprehensive exploration of the latest innovations for advancements in enhancing selectivity of nanozymes for theranostic nanoplatforms

Li,

Fan,

Mei

2023

Nanoscale

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“…26 Expanding the catalytic range to neutral or even alkaline conditions is desirable to overcome the pH limitations of nanozymes. 27,28 Efforts have been made to regulate the enzyme-mimic activity of some novel nanozymes at neutral pH, including surface structural functionalization, external stimuli response (e.g., light and magnet), and chemical activation. 29−33 For example, Lu et al revealed a smart switch by Cr 6+ on Ag nanoparticles to adjust the surface electronic redistribution and therefore enhance the peroxidase-like activity.…”

Section: Introductionmentioning

confidence: 99%

Hydrolysis-Induced Cu₂O Networks and the Triggered Peroxidase-Mimic Activity by Cr⁶⁺ under Neutral Conditions

Huang,

Wen,

Gao

et al. 2024

Inorg. Chem.

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The current small-scale synthesis and relatively large size of Cu 2 O have limited its practical applications. Herein, we developed a hydrolysis strategy to prepare phase-pure Cu 2 O networks composed of small granules (ca. 25 nm) on a gram scale. The preparation involves in situ hydrolyzing the H x [Cu x Cl 2x ] complexes prereduced in N,N′-dimethylformamide (DMF). The DMF-soluble H x [Cu x Cl 2x ] complexes are critical for the homogeneous nucleation of CuCl seeds and subsequent hydrolysis, allowing for separate control over the nucleation and growth stages to regulate the formation of Cu 2 O networks. The novel Cu 2 O networks possess numerous exposed active sites and hierarchical porosities, conferring high catalytic activity and fast mass transfer capability. The inherent peroxidase-mimic activity of Cu 2 O is severely inhibited under neutral conditions but can be triggered by Cr 6+ , enabling the colorimetric assay of Cr 6+ with the assistance of the oxidation-induced color change of 3,3′,5,5′tetramethylbenzidine. Through density functional theory calculation, we confirmed that the attachment of Cr 6+ on the Cu 2 O surface reduced the dissociation energy of H 2 O 2 , enhancing the enzyme-mimic activity. The colorimetric detection method demonstrated a sensitive and specific assay capability for Cr 6+ (LOD = 0.095 μM). Our work offers a straightforward protocol for novel design of metal or metal-based nanomaterials for nanozymes or other applications.

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Nanozyme’s catalytic activity at neutral pH: reaction substrates and application in sensing

Cited by 15 publications

References 120 publications

Perspectives on Usage of Functional Nanomaterials in Antimicrobial Therapy for Antibiotic-Resistant Bacterial Infections

Perspectives on Usage of Functional Nanomaterials in Antimicrobial Therapy for Antibiotic-Resistant Bacterial Infections

A comprehensive exploration of the latest innovations for advancements in enhancing selectivity of nanozymes for theranostic nanoplatforms

Hydrolysis-Induced Cu₂O Networks and the Triggered Peroxidase-Mimic Activity by Cr⁶⁺ under Neutral Conditions

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Nanozyme’s catalytic activity at neutral pH: reaction substrates and application in sensing

Cited by 15 publications

References 120 publications

Perspectives on Usage of Functional Nanomaterials in Antimicrobial Therapy for Antibiotic-Resistant Bacterial Infections

Perspectives on Usage of Functional Nanomaterials in Antimicrobial Therapy for Antibiotic-Resistant Bacterial Infections

A comprehensive exploration of the latest innovations for advancements in enhancing selectivity of nanozymes for theranostic nanoplatforms

Hydrolysis-Induced Cu2O Networks and the Triggered Peroxidase-Mimic Activity by Cr6+ under Neutral Conditions

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Hydrolysis-Induced Cu₂O Networks and the Triggered Peroxidase-Mimic Activity by Cr⁶⁺ under Neutral Conditions