Nanozymes: a new choice for disease treatment

Hou, Yaxin; Zhang, RuoFei; Yan, Xiyun

doi:10.1360/ssv-2019-0216

Cited by 2 publications

(1 citation statement)

References 32 publications

(33 reference statements)

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“…With rapid development in nanomaterial science and enzymology, inorganic nanomaterials with enzyme-mimicking properties have been developed to eliminate aberrant ROS for healthy physiological functioning ( Wu et al, 2019b ). In 2007, Chinese scientists discovered that Fe 3 O 4 nanoparticles had horseradish peroxidase (HRP)-like properties, dissolving the long-held belief that inorganic materials are biologically inert, and opening the field of nanozyme research ( Fan et al, 2020a ). Any nanozyme, a nanomaterial with enzymatic activity, is classified into two categories–a nanomaterial modified to associate with a natural enzyme or a group of enzymes or nanomaterials that have enzymatic properties ( Dutta et al, 2013 ; Wan et al, 2014 ).…”

Section: Introductionmentioning

confidence: 99%

Nanozymes Regulate Redox Homeostasis in ROS-Related Inflammation

Liu

Dai

et al. 2021

Front. Chem.

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Reactive oxygen species (ROS), in moderate amounts, play an essential role in regulating different physiological functions in organisms. However, increased amounts of ROS may cause oxidative stress and damage to biomolecules, leading to a variety of diseases including inflammation and even cancer. Therefore, ROS scavenging reagents are needed to maintain healthy levels of ROS. With considerable advances in nanotechnology, nanozymes possess SOD or CAT-like activities with outstanding free radical scavenging activity, facile synthesis conditions, and excellent biocompatibility. Based on these extraordinary properties, nanozymes has been used to modulate the redox homeostasis and relieve the ROS-related injury. This has led to the emergence of nanozyme-based therapies. In the current review, we presented recently developed applications of nanozymes to treat ROS-dependent disorders with an emphasis on inflammatory and brain diseases.

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