Nanozymes and their emerging applications in biomedicine

Ahmadi, Sepideh; Rahimizadeh, Kamal; Shafiee, Ali; Rabiee, Navid; Iravani, Siavash

doi:10.1016/j.procbio.2023.06.014

Cited by 12 publications

(1 citation statement)

References 211 publications

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“…96 Ahmadi et al reported that nanozymes, including CeVO 4 NPs, can be applied in biosensing. 105 The mechanism of action of CeVO 4 NPs in biosensing is not fully understood and is an active area of research. CeVO 4 NPs have been shown to exhibit biomimetic catalytic activity, which is favorable for bioreceptors in biosensors, and this is one of the proposed mechanisms.…”

Section: Biosensing Application Of Cevo4 Npsmentioning

confidence: 99%

Biomedical applications of cerium vanadate nanoparticles: a review

Farasati Far,

Maleki-baladi,

Fathi-karkan

et al. 2024

J. Mater. Chem. B

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Section: Biosensing Application Of Cevo4 Npsmentioning

confidence: 99%

Biomedical applications of cerium vanadate nanoparticles: a review

Farasati Far,

Maleki-baladi,

Fathi-karkan

et al. 2024

J. Mater. Chem. B

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Protein Aggregation on Metal Oxides Governs Catalytic Activity and Cellular Uptake

Nißler,

Dennebouy,

Gogos

et al. 2024

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Engineering of catalytically active inorganic nanomaterials holds promising prospects for biomedicine. Catalytically active metal oxides show applications in enhancing wound healing but have also been employed to induce cell death in photodynamic or radiation therapy. Upon introduction into a biological system, nanomaterials are exposed to complex fluids, causing interaction and adsorption of ions and proteins. While protein corona formation on nanomaterials is acknowledged, its modulation of nanomaterial catalytic efficacy is less understood. In this study, proteomic analyses and nano‐analytic methodologies quantify and characterize adsorbed proteins, correlating this protein layer with metal oxide catalytic activity in vitro and in vivo. The protein corona comprises up to 280 different proteins, constituting up to 38% by weight. Enhanced complement factors and other opsonins on nanocatalyst surfaces lead to their uptake into macrophages when applied topically, localizing >99% of the nanomaterials in tissue‐resident macrophages. Initially, the formation of the protein corona significantly reduces the nanocatalysts' activity, but this activity can be partially recovered in endosomal conditions due to the proteolytic degradation of the corona. Overall, the research reveals the complex relationship between physisorbed proteins and the catalytic characteristics of specific metal oxide nanoparticles, providing design parameters for optimizing nanocatalysts in complex biological environments.

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